Advanced Paternal Age and Sperm Proteome Dynamics: A Possible Explanation for Age-Associated Male Fertility Decline

Advanced Paternal Age and Sperm Proteome Dynamics: A Possible Explanation for Age-Associated Male Fertility Decline

Male fertility is strongly influenced by environmental exposures, lifestyle, and advancing age. While advanced paternal age (APA) has been linked with a progressive decline in male fertility, poor reproductive outcomes, and decreased offspring health, the molecular mechanisms underlying these altera...

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Bibliographic Details
Main Authors: Joana Santiago, Joana V. Silva, Manuel A. S. Santos, Margarida Fardilha
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
advanced paternal age
male infertility
protein
phosphorylation
spermatozoa
Online Access:https://www.mdpi.com/2073-4409/14/11/813
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