Disseminated Gastrointestinal Basidiobolomycosis: A Case Report with Review of Diagnostic Clues
Introduction. Basidiobolomycosis is a rare fungal infection caused by an environmental saprophyte, Basidiobolus ranarum. It usually presents as a chronic subcutaneous infection; however, few cases of gastrointestinal involvement have been reported. The exact transmission route of gastrointestinal ca...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2024/5741625 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832544227501801472 |
|---|---|
| author | Neda Soleimani Mohammad Hossein Anbardar Hamed Nikoupour Faranak Derakhshan Mojtaba Shafiekhani Sahand Mohammadzadeh Seyed Mohamad Sakhaei Mahsa Farhadi |
| author_facet | Neda Soleimani Mohammad Hossein Anbardar Hamed Nikoupour Faranak Derakhshan Mojtaba Shafiekhani Sahand Mohammadzadeh Seyed Mohamad Sakhaei Mahsa Farhadi |
| author_sort | Neda Soleimani |
| collection | DOAJ |
| description | Introduction. Basidiobolomycosis is a rare fungal infection caused by an environmental saprophyte, Basidiobolus ranarum. It usually presents as a chronic subcutaneous infection; however, few cases of gastrointestinal involvement have been reported. The exact transmission route of gastrointestinal cases is not clear, and diagnosis always requires a high index of suspicion because it tends to mimic other inflammatory and neoplastic conditions. Case Report. A 31-year-old immunocompetent woman presented with abdominal pain and an advanced colon mass. She was completely well until about 1.5 years ago, when she underwent bariatric surgery. One year after surgery, chronic abdominal pain developed. A colonoscopy showed an ulcerative lesion in the descending colon, and the biopsy was in favor of ulcerative colitis. Despite immunosuppressive treatment, there was no improvement, and with worsening symptoms, more investigations revealed advanced colon mass with entrapment of the stomach and pancreas. Colonic mucosa biopsy and trucut biopsy of the mass showed just necrosis and acute inflammation; thus, she underwent exploratory laparotomy with colectomy, partial gastrectomy, distal pancreatectomy, and left nephrectomy. On pathologic examination, there was granulomatous inflammation plus the Splendore–Hoeppli phenomenon around fungal hyphae, which was diagnostic for gastrointestinal basidiobolomycosis. Previous pathology slides were reviewed and revealed a tiny focus of basidiobolomycosis. After 6 months of treatment with itraconazole, she is relatively well without any clinical or radiologic abnormalities. Conclusion. Our case highlights the significance of suspicion for basidiobolomycosis in ulcerative and necrotic lesions with increased eosinophils, especially in the presence of abdominal mass and systemic eosinophilia. |
| format | Article |
| id | doaj-art-cde2333e6a484d1eaeeae749864de83e |
| institution | Kabale University |
| issn | 1687-9635 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-cde2333e6a484d1eaeeae749864de83e2025-02-03T10:52:36ZengWileyCase Reports in Medicine1687-96352024-01-01202410.1155/2024/5741625Disseminated Gastrointestinal Basidiobolomycosis: A Case Report with Review of Diagnostic CluesNeda Soleimani0Mohammad Hossein Anbardar1Hamed Nikoupour2Faranak Derakhshan3Mojtaba Shafiekhani4Sahand Mohammadzadeh5Seyed Mohamad Sakhaei6Mahsa Farhadi7Department of PathologyDepartment of PathologyShiraz Organ Transplant CenterDepartment of PathologyDepartment of Clinical PharmacyDepartment of PathologyDepartment of RadiologyDepartment of PathologyIntroduction. Basidiobolomycosis is a rare fungal infection caused by an environmental saprophyte, Basidiobolus ranarum. It usually presents as a chronic subcutaneous infection; however, few cases of gastrointestinal involvement have been reported. The exact transmission route of gastrointestinal cases is not clear, and diagnosis always requires a high index of suspicion because it tends to mimic other inflammatory and neoplastic conditions. Case Report. A 31-year-old immunocompetent woman presented with abdominal pain and an advanced colon mass. She was completely well until about 1.5 years ago, when she underwent bariatric surgery. One year after surgery, chronic abdominal pain developed. A colonoscopy showed an ulcerative lesion in the descending colon, and the biopsy was in favor of ulcerative colitis. Despite immunosuppressive treatment, there was no improvement, and with worsening symptoms, more investigations revealed advanced colon mass with entrapment of the stomach and pancreas. Colonic mucosa biopsy and trucut biopsy of the mass showed just necrosis and acute inflammation; thus, she underwent exploratory laparotomy with colectomy, partial gastrectomy, distal pancreatectomy, and left nephrectomy. On pathologic examination, there was granulomatous inflammation plus the Splendore–Hoeppli phenomenon around fungal hyphae, which was diagnostic for gastrointestinal basidiobolomycosis. Previous pathology slides were reviewed and revealed a tiny focus of basidiobolomycosis. After 6 months of treatment with itraconazole, she is relatively well without any clinical or radiologic abnormalities. Conclusion. Our case highlights the significance of suspicion for basidiobolomycosis in ulcerative and necrotic lesions with increased eosinophils, especially in the presence of abdominal mass and systemic eosinophilia.http://dx.doi.org/10.1155/2024/5741625 |
| spellingShingle | Neda Soleimani Mohammad Hossein Anbardar Hamed Nikoupour Faranak Derakhshan Mojtaba Shafiekhani Sahand Mohammadzadeh Seyed Mohamad Sakhaei Mahsa Farhadi Disseminated Gastrointestinal Basidiobolomycosis: A Case Report with Review of Diagnostic Clues Case Reports in Medicine |
| title | Disseminated Gastrointestinal Basidiobolomycosis: A Case Report with Review of Diagnostic Clues |
| title_full | Disseminated Gastrointestinal Basidiobolomycosis: A Case Report with Review of Diagnostic Clues |
| title_fullStr | Disseminated Gastrointestinal Basidiobolomycosis: A Case Report with Review of Diagnostic Clues |
| title_full_unstemmed | Disseminated Gastrointestinal Basidiobolomycosis: A Case Report with Review of Diagnostic Clues |
| title_short | Disseminated Gastrointestinal Basidiobolomycosis: A Case Report with Review of Diagnostic Clues |
| title_sort | disseminated gastrointestinal basidiobolomycosis a case report with review of diagnostic clues |
| url | http://dx.doi.org/10.1155/2024/5741625 |
| work_keys_str_mv | AT nedasoleimani disseminatedgastrointestinalbasidiobolomycosisacasereportwithreviewofdiagnosticclues AT mohammadhosseinanbardar disseminatedgastrointestinalbasidiobolomycosisacasereportwithreviewofdiagnosticclues AT hamednikoupour disseminatedgastrointestinalbasidiobolomycosisacasereportwithreviewofdiagnosticclues AT faranakderakhshan disseminatedgastrointestinalbasidiobolomycosisacasereportwithreviewofdiagnosticclues AT mojtabashafiekhani disseminatedgastrointestinalbasidiobolomycosisacasereportwithreviewofdiagnosticclues AT sahandmohammadzadeh disseminatedgastrointestinalbasidiobolomycosisacasereportwithreviewofdiagnosticclues AT seyedmohamadsakhaei disseminatedgastrointestinalbasidiobolomycosisacasereportwithreviewofdiagnosticclues AT mahsafarhadi disseminatedgastrointestinalbasidiobolomycosisacasereportwithreviewofdiagnosticclues |