Tapinarof Nanogels as a Promising Therapeutic Approach
Psoriasis is a chronic inflammatory skin disease characterised by increased oxidative stress, the overproliferation of keratinocytes, the accumulation of inflammatory mediators, and skin barrier damage. Although a number of therapeutic options are available, finding long-term treatments that are wel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/6/731 |
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| author | Barbara Balogh Ágota Pető Pálma Fehér Zoltán Ujhelyi Ildikó Bácskay |
| author_facet | Barbara Balogh Ágota Pető Pálma Fehér Zoltán Ujhelyi Ildikó Bácskay |
| author_sort | Barbara Balogh |
| collection | DOAJ |
| description | Psoriasis is a chronic inflammatory skin disease characterised by increased oxidative stress, the overproliferation of keratinocytes, the accumulation of inflammatory mediators, and skin barrier damage. Although a number of therapeutic options are available, finding long-term treatments that are well-tolerated and patient-friendly treatments remains a challenge. Tapinarof is a new type of aryl hydrocarbon receptor (AhR) modulator that has recently attracted attention as a promising non-steroidal alternative. However, its application may be limited by its poor water solubility and low degree of skin penetration. Nanotechnology-based drug carriers, specially nanogels, offer new opportunities to overcome these limitations by combining the advantages of targeted drug delivery and enhanced skin penetration. Furthermore, nanogel formulations can improve skin hydration and support the restoration of skin barrier function, which are important in the treatment of psoriasis. This review focuses on current and emerging therapeutic approaches, with particular emphasis on the potential of incorporating tapinarof into nanogel formulations as a novel alternative to topical psoriasis treatment. |
| format | Article |
| id | doaj-art-cde038d05ebc439a90e274e61e4ecbcc |
| institution | DOAJ |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-cde038d05ebc439a90e274e61e4ecbcc2025-08-20T03:16:25ZengMDPI AGPharmaceutics1999-49232025-06-0117673110.3390/pharmaceutics17060731Tapinarof Nanogels as a Promising Therapeutic ApproachBarbara Balogh0Ágota Pető1Pálma Fehér2Zoltán Ujhelyi3Ildikó Bácskay4Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Rex Ferenc Utca 1, H-4002 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Rex Ferenc Utca 1, H-4002 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Rex Ferenc Utca 1, H-4002 Debrecen, HungaryDepartment of Industrial Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Rex Ferenc Utca 1, H-4002 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Rex Ferenc Utca 1, H-4002 Debrecen, HungaryPsoriasis is a chronic inflammatory skin disease characterised by increased oxidative stress, the overproliferation of keratinocytes, the accumulation of inflammatory mediators, and skin barrier damage. Although a number of therapeutic options are available, finding long-term treatments that are well-tolerated and patient-friendly treatments remains a challenge. Tapinarof is a new type of aryl hydrocarbon receptor (AhR) modulator that has recently attracted attention as a promising non-steroidal alternative. However, its application may be limited by its poor water solubility and low degree of skin penetration. Nanotechnology-based drug carriers, specially nanogels, offer new opportunities to overcome these limitations by combining the advantages of targeted drug delivery and enhanced skin penetration. Furthermore, nanogel formulations can improve skin hydration and support the restoration of skin barrier function, which are important in the treatment of psoriasis. This review focuses on current and emerging therapeutic approaches, with particular emphasis on the potential of incorporating tapinarof into nanogel formulations as a novel alternative to topical psoriasis treatment.https://www.mdpi.com/1999-4923/17/6/731tapinarofnon-steroidaryl hydrocarbon receptordermatological therapiesnanotechnology for psoriasis |
| spellingShingle | Barbara Balogh Ágota Pető Pálma Fehér Zoltán Ujhelyi Ildikó Bácskay Tapinarof Nanogels as a Promising Therapeutic Approach Pharmaceutics tapinarof non-steroid aryl hydrocarbon receptor dermatological therapies nanotechnology for psoriasis |
| title | Tapinarof Nanogels as a Promising Therapeutic Approach |
| title_full | Tapinarof Nanogels as a Promising Therapeutic Approach |
| title_fullStr | Tapinarof Nanogels as a Promising Therapeutic Approach |
| title_full_unstemmed | Tapinarof Nanogels as a Promising Therapeutic Approach |
| title_short | Tapinarof Nanogels as a Promising Therapeutic Approach |
| title_sort | tapinarof nanogels as a promising therapeutic approach |
| topic | tapinarof non-steroid aryl hydrocarbon receptor dermatological therapies nanotechnology for psoriasis |
| url | https://www.mdpi.com/1999-4923/17/6/731 |
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