Effects of Exercise on Depression and Anxiety in Lung Cancer Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

This study aims to investigate the effects of exercise on depression and anxiety in lung cancer survivors and identify the optimal exercise prescription for this population. Searches were conducted in PubMed, Web of Science, Cochrane Library, Embase, Scopus, CNKI, and Wanfang Data up to 7 January 20...

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Main Authors: Cuiqing Zhao, Xifeng Tao, Bingkai Lei, Yifan Zhang, Gen Li, Yuanyuan Lv, Laikang Yu
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Current Oncology
Subjects:
Online Access:https://www.mdpi.com/1718-7729/32/6/304
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author Cuiqing Zhao
Xifeng Tao
Bingkai Lei
Yifan Zhang
Gen Li
Yuanyuan Lv
Laikang Yu
author_facet Cuiqing Zhao
Xifeng Tao
Bingkai Lei
Yifan Zhang
Gen Li
Yuanyuan Lv
Laikang Yu
author_sort Cuiqing Zhao
collection DOAJ
description This study aims to investigate the effects of exercise on depression and anxiety in lung cancer survivors and identify the optimal exercise prescription for this population. Searches were conducted in PubMed, Web of Science, Cochrane Library, Embase, Scopus, CNKI, and Wanfang Data up to 7 January 2024. A meta-analysis was performed to calculate the standardized mean difference (SMD) and 95% confidence interval. Thirteen studies were included in this meta-analysis. Exercise significantly alleviated depression (SMD, −0.54; <i>p</i> = 0.002) and anxiety (SMD, −0.66; <i>p</i> = 0.0002) in lung cancer survivors. Subgroup analyses showed that aerobic exercise, exercise conducted >3 times per week, <60 min per session, and ≥180 min per week, were more effective in alleviating depression and anxiety, particularly in middle-aged individuals. In conclusion, exercise alleviates depression and anxiety in lung cancer survivors, particularly those who are middle-aged, and aerobic exercise may be the most effective intervention. This meta-analysis provides clinicians with evidence to recommend that lung cancer survivors engage in exercise more than three times per week, with each session lasting less than 60 min, aiming to achieve a total of 180 min per week by increasing the frequency of exercise.
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spelling doaj-art-cddeaa3f413c4ff8b7152afaf84d72542025-08-20T03:27:13ZengMDPI AGCurrent Oncology1198-00521718-77292025-05-0132630410.3390/curroncol32060304Effects of Exercise on Depression and Anxiety in Lung Cancer Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsCuiqing Zhao0Xifeng Tao1Bingkai Lei2Yifan Zhang3Gen Li4Yuanyuan Lv5Laikang Yu6Division of Physical Education, Myongji University, Seoul 03674, Republic of KoreaBeijing Key Laboratory of Sports Performance and Skill Assessment, Beijing Sport University, Beijing 100084, ChinaSchool of Physical Education, Xihua University, Chengdu 610039, ChinaDepartment of Strength and Conditioning Assessment and Monitoring, Beijing Sport University, Beijing 100084, ChinaSchool of Physical Education & Sports Science, South China Normal University, Guangzhou 510631, ChinaBeijing Key Laboratory of Sports Performance and Skill Assessment, Beijing Sport University, Beijing 100084, ChinaBeijing Key Laboratory of Sports Performance and Skill Assessment, Beijing Sport University, Beijing 100084, ChinaThis study aims to investigate the effects of exercise on depression and anxiety in lung cancer survivors and identify the optimal exercise prescription for this population. Searches were conducted in PubMed, Web of Science, Cochrane Library, Embase, Scopus, CNKI, and Wanfang Data up to 7 January 2024. A meta-analysis was performed to calculate the standardized mean difference (SMD) and 95% confidence interval. Thirteen studies were included in this meta-analysis. Exercise significantly alleviated depression (SMD, −0.54; <i>p</i> = 0.002) and anxiety (SMD, −0.66; <i>p</i> = 0.0002) in lung cancer survivors. Subgroup analyses showed that aerobic exercise, exercise conducted >3 times per week, <60 min per session, and ≥180 min per week, were more effective in alleviating depression and anxiety, particularly in middle-aged individuals. In conclusion, exercise alleviates depression and anxiety in lung cancer survivors, particularly those who are middle-aged, and aerobic exercise may be the most effective intervention. This meta-analysis provides clinicians with evidence to recommend that lung cancer survivors engage in exercise more than three times per week, with each session lasting less than 60 min, aiming to achieve a total of 180 min per week by increasing the frequency of exercise.https://www.mdpi.com/1718-7729/32/6/304exerciselung cancerdepressionanxiety
spellingShingle Cuiqing Zhao
Xifeng Tao
Bingkai Lei
Yifan Zhang
Gen Li
Yuanyuan Lv
Laikang Yu
Effects of Exercise on Depression and Anxiety in Lung Cancer Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Current Oncology
exercise
lung cancer
depression
anxiety
title Effects of Exercise on Depression and Anxiety in Lung Cancer Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_full Effects of Exercise on Depression and Anxiety in Lung Cancer Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_fullStr Effects of Exercise on Depression and Anxiety in Lung Cancer Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_full_unstemmed Effects of Exercise on Depression and Anxiety in Lung Cancer Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_short Effects of Exercise on Depression and Anxiety in Lung Cancer Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_sort effects of exercise on depression and anxiety in lung cancer survivors a systematic review and meta analysis of randomized controlled trials
topic exercise
lung cancer
depression
anxiety
url https://www.mdpi.com/1718-7729/32/6/304
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