Visualizing acyl carrier protein interactions within a crosslinked type I polyketide synthase

Visualizing acyl carrier protein interactions within a crosslinked type I polyketide synthase

Abstract Using a combination of dual covalent crosslinking and cryo-EM analyses, we elucidate the structure of mycocerosic acid synthase from Mycobacterium tuberculosis trapped in two distinct catalytic states during its iterative cycle. These structures reveal domain architecture of the acyl carrie...

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Bibliographic Details
Main Authors: Ziran Jiang, Graham W. Heberlig, Jeffrey A. Chen, Jennifer Huynh, James J. La Clair, Michael D. Burkart
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-63024-x
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