A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery

A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery

Disruption of cholinesterases and, as a consequence, increased levels of acetylcholine lead to serious disturbances in the functioning of the nervous system, including death. The need for rapid administration of an antidote to restore esterase activity is critical, but practical implementation of th...

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Bibliographic Details
Main Authors: Elina E. Mansurova, Andrey A. Maslennikov, Anna P. Lyubina, Alexandra D. Voloshina, Irek R. Nizameev, Marsil K. Kadirov, Anzhela A. Mikhailova, Polina V. Mikshina, Albina Y. Ziganshina, Igor S. Antipin
Format: Article
Language:English
Published: Beilstein-Institut 2025-01-01
Series:Beilstein Journal of Nanotechnology
Subjects:
acetylcholine
antidote delivery
artificial cholinesterase
atropine
nanocarrier
resorcinarene
Online Access:https://doi.org/10.3762/bjnano.16.2
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