Factors Implicated in Radiation Therapy Failure and Radiosensitization of Prostate Cancer
Tissue markers may be helpful in enhancing prediction of radiation therapy (RT) failure of prostate cancer (PCa). Among the various biomarkers tested in Phase III randomized trials conducted by the Radiation Therapy Oncology Group, p16, Ki-67, MDM2, COX-2, and PKA yielded the most robust data in pre...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/593241 |
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| _version_ | 1832554180203511808 |
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| author | Helmut Bonkhoff |
| author_facet | Helmut Bonkhoff |
| author_sort | Helmut Bonkhoff |
| collection | DOAJ |
| description | Tissue markers may be helpful in enhancing prediction of radiation therapy (RT) failure of prostate cancer (PCa). Among the various biomarkers tested in Phase III randomized trials conducted by the Radiation Therapy Oncology Group, p16, Ki-67, MDM2, COX-2, and PKA yielded the most robust data in predicting RT failure. Other pathways involved in RT failure are also implicated in the development of castration-resistant PCa, including the hypersensitive androgen receptor, EGFR, VEGF-R, and PI3K/Akt. Most of them are detectable in PCa tissue even at the time of initial diagnosis. Emerging evidence suggests that RT failure of PCa results from a multifactorial and heterogeneous disease process. A number of tissue markers are available to identify patients at high risk to fail RT. Some of these markers have the promise to be targeted by drugs currently available to enhance the efficacy of RT and delay disease progression. |
| format | Article |
| id | doaj-art-cdc8a2aa15ac407bb51e2643a3de1f10 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-cdc8a2aa15ac407bb51e2643a3de1f102025-02-03T05:52:18ZengWileyProstate Cancer2090-31112090-312X2012-01-01201210.1155/2012/593241593241Factors Implicated in Radiation Therapy Failure and Radiosensitization of Prostate CancerHelmut Bonkhoff0Pathology Laboratory, Großbeerenstraße 12, 12209 Berlin, GermanyTissue markers may be helpful in enhancing prediction of radiation therapy (RT) failure of prostate cancer (PCa). Among the various biomarkers tested in Phase III randomized trials conducted by the Radiation Therapy Oncology Group, p16, Ki-67, MDM2, COX-2, and PKA yielded the most robust data in predicting RT failure. Other pathways involved in RT failure are also implicated in the development of castration-resistant PCa, including the hypersensitive androgen receptor, EGFR, VEGF-R, and PI3K/Akt. Most of them are detectable in PCa tissue even at the time of initial diagnosis. Emerging evidence suggests that RT failure of PCa results from a multifactorial and heterogeneous disease process. A number of tissue markers are available to identify patients at high risk to fail RT. Some of these markers have the promise to be targeted by drugs currently available to enhance the efficacy of RT and delay disease progression.http://dx.doi.org/10.1155/2012/593241 |
| spellingShingle | Helmut Bonkhoff Factors Implicated in Radiation Therapy Failure and Radiosensitization of Prostate Cancer Prostate Cancer |
| title | Factors Implicated in Radiation Therapy Failure and Radiosensitization of Prostate Cancer |
| title_full | Factors Implicated in Radiation Therapy Failure and Radiosensitization of Prostate Cancer |
| title_fullStr | Factors Implicated in Radiation Therapy Failure and Radiosensitization of Prostate Cancer |
| title_full_unstemmed | Factors Implicated in Radiation Therapy Failure and Radiosensitization of Prostate Cancer |
| title_short | Factors Implicated in Radiation Therapy Failure and Radiosensitization of Prostate Cancer |
| title_sort | factors implicated in radiation therapy failure and radiosensitization of prostate cancer |
| url | http://dx.doi.org/10.1155/2012/593241 |
| work_keys_str_mv | AT helmutbonkhoff factorsimplicatedinradiationtherapyfailureandradiosensitizationofprostatecancer |