Efficacy of combined topical nepafenac 0.3% with suprachoroidal injection of triamcinolone acetonide using a modified custom needle in pseudopkakic cystoid macular edema
Abstract Purpose The present study evaluated the efficacy of combined use of suprachoroidal injection of triamcinolone acetonide (SCTA) using a modified custom needle with topical nepafenac 0.3% in the treatment of pseudophakic cystoid macular edema (PCME). Methods A prospective randomized study tha...
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2025-07-01
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| Online Access: | https://doi.org/10.1186/s12886-025-03972-6 |
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| author | Amin E. Nawar |
| author_facet | Amin E. Nawar |
| author_sort | Amin E. Nawar |
| collection | DOAJ |
| description | Abstract Purpose The present study evaluated the efficacy of combined use of suprachoroidal injection of triamcinolone acetonide (SCTA) using a modified custom needle with topical nepafenac 0.3% in the treatment of pseudophakic cystoid macular edema (PCME). Methods A prospective randomized study that included sixty eyes of 60 patients with PCME. Patients were divided in two groups, group (1) included 30 patients who received topical nepafenac 0.3% eye drops alone and group (2) that included 30 patients who received a single SCTA (4 mg/0.1 ml) combined with topical nepafenac 0.3% eye drops. Results In group 1, the central macular thickness (CMT) decreased from 457.4 ± 81.4 um to 252.9 ± 54.6 um after 12 months. In respect to group 2, CMT declined from 455.1 ± 79.6 um to 213.7 ± 14.2 um after 12 months. The CMT was more significantly reduced in group 2 after 1,3,6,9 and 12 months (p value < 0.001). Group 1 showed improvement of best corrected visual acuity (BCVA) by log MAR from 0.9(0.8–1) to 0.2(0.1–0.4) after 12 months, while group 2 showed improvement from 0.9(0.8–1) to 0.1(0–0.1) after 12 months. More significant improvement of BCVA was detected in group 2 after 1,3,6 and 9 months with p value < 0.001 and after 12 months with p value 0.001. Conclusion Combined SCTA using this modified custom needle with topical nepafenac 0.3% resulted in better anatomical and functional results in PCME patients compared to topical nepafenac 0.3% alone. The study was prospectively registered with clinical trial.gov ID (NCT04690608) in 27–12-2020. |
| format | Article |
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| institution | Kabale University |
| issn | 1471-2415 |
| language | English |
| publishDate | 2025-07-01 |
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| series | BMC Ophthalmology |
| spelling | doaj-art-cdbec03558314f4682bd681d1b21a9562025-08-20T04:01:24ZengBMCBMC Ophthalmology1471-24152025-07-012511910.1186/s12886-025-03972-6Efficacy of combined topical nepafenac 0.3% with suprachoroidal injection of triamcinolone acetonide using a modified custom needle in pseudopkakic cystoid macular edemaAmin E. Nawar0Ophthalmology Department, Faculty of Medicine, Tanta UniversityAbstract Purpose The present study evaluated the efficacy of combined use of suprachoroidal injection of triamcinolone acetonide (SCTA) using a modified custom needle with topical nepafenac 0.3% in the treatment of pseudophakic cystoid macular edema (PCME). Methods A prospective randomized study that included sixty eyes of 60 patients with PCME. Patients were divided in two groups, group (1) included 30 patients who received topical nepafenac 0.3% eye drops alone and group (2) that included 30 patients who received a single SCTA (4 mg/0.1 ml) combined with topical nepafenac 0.3% eye drops. Results In group 1, the central macular thickness (CMT) decreased from 457.4 ± 81.4 um to 252.9 ± 54.6 um after 12 months. In respect to group 2, CMT declined from 455.1 ± 79.6 um to 213.7 ± 14.2 um after 12 months. The CMT was more significantly reduced in group 2 after 1,3,6,9 and 12 months (p value < 0.001). Group 1 showed improvement of best corrected visual acuity (BCVA) by log MAR from 0.9(0.8–1) to 0.2(0.1–0.4) after 12 months, while group 2 showed improvement from 0.9(0.8–1) to 0.1(0–0.1) after 12 months. More significant improvement of BCVA was detected in group 2 after 1,3,6 and 9 months with p value < 0.001 and after 12 months with p value 0.001. Conclusion Combined SCTA using this modified custom needle with topical nepafenac 0.3% resulted in better anatomical and functional results in PCME patients compared to topical nepafenac 0.3% alone. The study was prospectively registered with clinical trial.gov ID (NCT04690608) in 27–12-2020.https://doi.org/10.1186/s12886-025-03972-6Pseudophakic cystoid macular edemaSuprachoroidal injectionTriamcinolone acetonideOptical coherence tomography |
| spellingShingle | Amin E. Nawar Efficacy of combined topical nepafenac 0.3% with suprachoroidal injection of triamcinolone acetonide using a modified custom needle in pseudopkakic cystoid macular edema BMC Ophthalmology Pseudophakic cystoid macular edema Suprachoroidal injection Triamcinolone acetonide Optical coherence tomography |
| title | Efficacy of combined topical nepafenac 0.3% with suprachoroidal injection of triamcinolone acetonide using a modified custom needle in pseudopkakic cystoid macular edema |
| title_full | Efficacy of combined topical nepafenac 0.3% with suprachoroidal injection of triamcinolone acetonide using a modified custom needle in pseudopkakic cystoid macular edema |
| title_fullStr | Efficacy of combined topical nepafenac 0.3% with suprachoroidal injection of triamcinolone acetonide using a modified custom needle in pseudopkakic cystoid macular edema |
| title_full_unstemmed | Efficacy of combined topical nepafenac 0.3% with suprachoroidal injection of triamcinolone acetonide using a modified custom needle in pseudopkakic cystoid macular edema |
| title_short | Efficacy of combined topical nepafenac 0.3% with suprachoroidal injection of triamcinolone acetonide using a modified custom needle in pseudopkakic cystoid macular edema |
| title_sort | efficacy of combined topical nepafenac 0 3 with suprachoroidal injection of triamcinolone acetonide using a modified custom needle in pseudopkakic cystoid macular edema |
| topic | Pseudophakic cystoid macular edema Suprachoroidal injection Triamcinolone acetonide Optical coherence tomography |
| url | https://doi.org/10.1186/s12886-025-03972-6 |
| work_keys_str_mv | AT aminenawar efficacyofcombinedtopicalnepafenac03withsuprachoroidalinjectionoftriamcinoloneacetonideusingamodifiedcustomneedleinpseudopkakiccystoidmacularedema |