Hamster and Murine Models of Severe Destructive Lyme Arthritis
Arthritis is a frequent complication of infection in humans with Borrelia burgdorferi. Weeks to months following the onset of Lyme borreliosis, a histopathological reaction characteristic of synovitis including bone, joint, muscle, or tendon pain may occur. A subpopulation of patients may progress t...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/504215 |
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| author | Erik Munson Dean T. Nardelli Brian K. Du Chateau Steven M. Callister Ronald F. Schell |
| author_facet | Erik Munson Dean T. Nardelli Brian K. Du Chateau Steven M. Callister Ronald F. Schell |
| author_sort | Erik Munson |
| collection | DOAJ |
| description | Arthritis is a frequent complication of infection in humans with Borrelia burgdorferi. Weeks to months following the onset of Lyme borreliosis, a histopathological reaction characteristic of synovitis including bone, joint, muscle, or tendon pain may occur. A subpopulation of patients may progress to a chronic, debilitating arthritis months to years after infection which has been classified as severe destructive Lyme arthritis. This arthritis involves focal bone erosion and destruction of articular cartilage. Hamsters and mice are animal models that have been utilized to study articular manifestations of Lyme borreliosis. Infection of immunocompetent LSH hamsters or C3H mice results in a transient synovitis. However, severe destructive Lyme arthritis can be induced by infecting irradiated hamsters or mice and immunocompetent Borrelia-vaccinated hamsters, mice, and interferon-gamma- (IFN-γ-) deficient mice with viable B. burgdorferi. The hamster model of severe destructive Lyme arthritis facilitates easy assessment of Lyme borreliosis vaccine preparations for deleterious effects while murine models of severe destructive Lyme arthritis allow for investigation of mechanisms of immunopathology. |
| format | Article |
| id | doaj-art-cdbcdc4c8ff847248576ab66b04dd72b |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-cdbcdc4c8ff847248576ab66b04dd72b2025-02-03T06:07:32ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/504215504215Hamster and Murine Models of Severe Destructive Lyme ArthritisErik Munson0Dean T. Nardelli1Brian K. Du Chateau2Steven M. Callister3Ronald F. Schell4Wheaton Franciscan Laboratory, 11020 West Plank Court, Suite 100, Wauwatosa, WI 53226, USACollege of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USADako North America, Inc., Carpinteria, CA 93013, USASection of Infectious Diseases, Gundersen Lutheran Medical Center, La Crosse, WI 54601, USAWisconsin State Laboratory of Hygiene, Madison, WI 53706, USAArthritis is a frequent complication of infection in humans with Borrelia burgdorferi. Weeks to months following the onset of Lyme borreliosis, a histopathological reaction characteristic of synovitis including bone, joint, muscle, or tendon pain may occur. A subpopulation of patients may progress to a chronic, debilitating arthritis months to years after infection which has been classified as severe destructive Lyme arthritis. This arthritis involves focal bone erosion and destruction of articular cartilage. Hamsters and mice are animal models that have been utilized to study articular manifestations of Lyme borreliosis. Infection of immunocompetent LSH hamsters or C3H mice results in a transient synovitis. However, severe destructive Lyme arthritis can be induced by infecting irradiated hamsters or mice and immunocompetent Borrelia-vaccinated hamsters, mice, and interferon-gamma- (IFN-γ-) deficient mice with viable B. burgdorferi. The hamster model of severe destructive Lyme arthritis facilitates easy assessment of Lyme borreliosis vaccine preparations for deleterious effects while murine models of severe destructive Lyme arthritis allow for investigation of mechanisms of immunopathology.http://dx.doi.org/10.1155/2012/504215 |
| spellingShingle | Erik Munson Dean T. Nardelli Brian K. Du Chateau Steven M. Callister Ronald F. Schell Hamster and Murine Models of Severe Destructive Lyme Arthritis Clinical and Developmental Immunology |
| title | Hamster and Murine Models of Severe Destructive Lyme Arthritis |
| title_full | Hamster and Murine Models of Severe Destructive Lyme Arthritis |
| title_fullStr | Hamster and Murine Models of Severe Destructive Lyme Arthritis |
| title_full_unstemmed | Hamster and Murine Models of Severe Destructive Lyme Arthritis |
| title_short | Hamster and Murine Models of Severe Destructive Lyme Arthritis |
| title_sort | hamster and murine models of severe destructive lyme arthritis |
| url | http://dx.doi.org/10.1155/2012/504215 |
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