Acetone gas sensor based on chitosan-metal-organic framework mixed matrix membranes for diabetes diagnosis
Detecting diabetes in its early stages through non-invasive methods remains a major challenge for researchers. One promising approach involves the development of a rapid and sensitive chemiresistive sensor to measure acetone levels in exhaled breath-a potential biomarker for diabetes. In this study,...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893925000015 |
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| author | Lamia A. Siddig Ashraf Ali Shaikha S. Al Neyadi Yaser E. Greish Stefan Wuttke Saleh T. Mahmoud |
| author_facet | Lamia A. Siddig Ashraf Ali Shaikha S. Al Neyadi Yaser E. Greish Stefan Wuttke Saleh T. Mahmoud |
| author_sort | Lamia A. Siddig |
| collection | DOAJ |
| description | Detecting diabetes in its early stages through non-invasive methods remains a major challenge for researchers. One promising approach involves the development of a rapid and sensitive chemiresistive sensor to measure acetone levels in exhaled breath-a potential biomarker for diabetes. In this study, we successfully fabricated a novel composite sensor comprising chitosan, a linear polysaccharide, combined with a metal-organic framework (UiO-66-NH2 MOF) and the ionic liquid glycerol. This combination enhances the film-forming properties of the material, leveraging the MOF's high surface area and selective adsorption capabilities for superior performance.The sensor was designed to detect acetone through chemiresistive sensing and demonstrated remarkable response to acetone concentrations as low as 1 ppm. Operating at a low temperature of 60 °C with a bias voltage of 4 V, the sensor exhibited excellent functionality even in high-humidity environments. Furthermore, it showed good repeatability, long-term stability, and fast response and recovery times of 23 ± 0.25 s and 18 ± 0.1 s, respectively.These characteristics make the sensor suitable for biomedical applications. Its flexibility and eco-friendly design further underscore its potential as a real-time breath analyzer for diabetes detection. The results of this study suggest a promising pathway for future clinical implementation of this technology. |
| format | Article |
| id | doaj-art-cdbc64135b42449b8d06264c9e4be89f |
| institution | DOAJ |
| issn | 2666-8939 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj-art-cdbc64135b42449b8d06264c9e4be89f2025-08-20T02:52:21ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392025-03-01910066110.1016/j.carpta.2025.100661Acetone gas sensor based on chitosan-metal-organic framework mixed matrix membranes for diabetes diagnosisLamia A. Siddig0Ashraf Ali1Shaikha S. Al Neyadi2Yaser E. Greish3Stefan Wuttke4Saleh T. Mahmoud5Department of Physics, United Arab Emirates University, Al-Ain 15551, United Arab Emirates; Department of Chemistry, United Arab Emirates University, Al-Ain 15551, United Arab EmiratesDepartment of Physics, Khalifa University of Science and Technology, Abu Dhabi, P. O. Box 127788, United Arab EmiratesDepartment of Chemistry, United Arab Emirates University, Al-Ain 15551, United Arab EmiratesDepartment of Chemistry, United Arab Emirates University, Al-Ain 15551, United Arab EmiratesDepartment of Chemistry, United Arab Emirates University, Al-Ain 15551, United Arab Emirates; BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain; Academic Centre for Materials and Nanotechnology, AGH University of Krakow, Krakow, 30-059, PolandDepartment of Physics, United Arab Emirates University, Al-Ain 15551, United Arab Emirates; Corresponding author.Detecting diabetes in its early stages through non-invasive methods remains a major challenge for researchers. One promising approach involves the development of a rapid and sensitive chemiresistive sensor to measure acetone levels in exhaled breath-a potential biomarker for diabetes. In this study, we successfully fabricated a novel composite sensor comprising chitosan, a linear polysaccharide, combined with a metal-organic framework (UiO-66-NH2 MOF) and the ionic liquid glycerol. This combination enhances the film-forming properties of the material, leveraging the MOF's high surface area and selective adsorption capabilities for superior performance.The sensor was designed to detect acetone through chemiresistive sensing and demonstrated remarkable response to acetone concentrations as low as 1 ppm. Operating at a low temperature of 60 °C with a bias voltage of 4 V, the sensor exhibited excellent functionality even in high-humidity environments. Furthermore, it showed good repeatability, long-term stability, and fast response and recovery times of 23 ± 0.25 s and 18 ± 0.1 s, respectively.These characteristics make the sensor suitable for biomedical applications. Its flexibility and eco-friendly design further underscore its potential as a real-time breath analyzer for diabetes detection. The results of this study suggest a promising pathway for future clinical implementation of this technology.http://www.sciencedirect.com/science/article/pii/S2666893925000015Acetone gas sensorChitosanmixed matrix membraneMetal-organic frameworkChemiresistive gas sensorBreath analyzerUiO-66-NH2 |
| spellingShingle | Lamia A. Siddig Ashraf Ali Shaikha S. Al Neyadi Yaser E. Greish Stefan Wuttke Saleh T. Mahmoud Acetone gas sensor based on chitosan-metal-organic framework mixed matrix membranes for diabetes diagnosis Carbohydrate Polymer Technologies and Applications Acetone gas sensor Chitosanmixed matrix membrane Metal-organic framework Chemiresistive gas sensor Breath analyzer UiO-66-NH2 |
| title | Acetone gas sensor based on chitosan-metal-organic framework mixed matrix membranes for diabetes diagnosis |
| title_full | Acetone gas sensor based on chitosan-metal-organic framework mixed matrix membranes for diabetes diagnosis |
| title_fullStr | Acetone gas sensor based on chitosan-metal-organic framework mixed matrix membranes for diabetes diagnosis |
| title_full_unstemmed | Acetone gas sensor based on chitosan-metal-organic framework mixed matrix membranes for diabetes diagnosis |
| title_short | Acetone gas sensor based on chitosan-metal-organic framework mixed matrix membranes for diabetes diagnosis |
| title_sort | acetone gas sensor based on chitosan metal organic framework mixed matrix membranes for diabetes diagnosis |
| topic | Acetone gas sensor Chitosanmixed matrix membrane Metal-organic framework Chemiresistive gas sensor Breath analyzer UiO-66-NH2 |
| url | http://www.sciencedirect.com/science/article/pii/S2666893925000015 |
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