Prediction of early mortality after cardioverter-defibrillator implantation for primary prevention of sudden cardiac death: focus on transthoracic echocardiography
Aim. To study the mortality rate of acute decompensated heart failure (ADHF) in patients with heart failure with reduced ejection fraction (HFrEF) within a year after implantation of cardioverter-defibrillator (ICD), to evaluate the potential of its prediction using transthoracic echocardiography.Ma...
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«FIRMA «SILICEA» LLC
2023-07-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5248 |
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| author | N. N. Ilov D. R. Stompel S. A. Boytsov O. V. Palnikova A. A. Nechepurenko |
| author_facet | N. N. Ilov D. R. Stompel S. A. Boytsov O. V. Palnikova A. A. Nechepurenko |
| author_sort | N. N. Ilov |
| collection | DOAJ |
| description | Aim. To study the mortality rate of acute decompensated heart failure (ADHF) in patients with heart failure with reduced ejection fraction (HFrEF) within a year after implantation of cardioverter-defibrillator (ICD), to evaluate the potential of its prediction using transthoracic echocardiography.Material and methods. The study included 384 patients with NYHA class 3-4 heart failure with left ventricular ejection fraction (LVEF) ≤35%, who were scheduled for ICD implantation for the primary prevention of sudden cardiac death (SCD). After ICD implantation, enrolled patients were followed up for a year to record the primary endpoint of death due to ADHF.Results. During the 1-year follow-up, the primary endpoint was recorded in 38 patients (10%). A univariate logistic regression identified 14 echocardiographic parameters with the highest predictive potential (p<0,1) associated with the studied endpoint. Based on multivariate regression analysis, a prognostic model was developed, which included three factors with the highest statistical significance: LVEF, right atrial (RA) medial-lateral size, and pulmonary artery systolic pressure. The diagnostic efficiency of the model was 78,7% (sensitivity, 82,4%; specificity, 78,3%). A decrease in LVEF ≤28% and an increase in (RA) medial-lateral size ≥3,9 cm were found to be independent predictors of the studied endpoint.Conclusion. Approximately 10% of HFrEF patients selected for ICD implantation for primary prevention of SCD die due to ADHF during the 1-year follow-up. Transthoracic echocardiography has potential to predict this outcome. |
| format | Article |
| id | doaj-art-cdb568fe52c04419932db1bc289a7528 |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2023-07-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-cdb568fe52c04419932db1bc289a75282025-08-20T03:21:31Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202023-07-0128610.15829/1560-4071-2023-52483744Prediction of early mortality after cardioverter-defibrillator implantation for primary prevention of sudden cardiac death: focus on transthoracic echocardiographyN. N. Ilov0D. R. Stompel1S. A. Boytsov2O. V. Palnikova3A. A. Nechepurenko4Astrakhan State Medical University; Federal Center for Cardiovascular SurgeryAstrakhan State Medical University; Federal Center for Cardiovascular SurgeryAstrakhan State Medical University; Federal Center for Cardiovascular SurgeryAstrakhan State Medical University; Federal Center for Cardiovascular SurgeryFederal Center for Cardiovascular SurgeryAim. To study the mortality rate of acute decompensated heart failure (ADHF) in patients with heart failure with reduced ejection fraction (HFrEF) within a year after implantation of cardioverter-defibrillator (ICD), to evaluate the potential of its prediction using transthoracic echocardiography.Material and methods. The study included 384 patients with NYHA class 3-4 heart failure with left ventricular ejection fraction (LVEF) ≤35%, who were scheduled for ICD implantation for the primary prevention of sudden cardiac death (SCD). After ICD implantation, enrolled patients were followed up for a year to record the primary endpoint of death due to ADHF.Results. During the 1-year follow-up, the primary endpoint was recorded in 38 patients (10%). A univariate logistic regression identified 14 echocardiographic parameters with the highest predictive potential (p<0,1) associated with the studied endpoint. Based on multivariate regression analysis, a prognostic model was developed, which included three factors with the highest statistical significance: LVEF, right atrial (RA) medial-lateral size, and pulmonary artery systolic pressure. The diagnostic efficiency of the model was 78,7% (sensitivity, 82,4%; specificity, 78,3%). A decrease in LVEF ≤28% and an increase in (RA) medial-lateral size ≥3,9 cm were found to be independent predictors of the studied endpoint.Conclusion. Approximately 10% of HFrEF patients selected for ICD implantation for primary prevention of SCD die due to ADHF during the 1-year follow-up. Transthoracic echocardiography has potential to predict this outcome.https://russjcardiol.elpub.ru/jour/article/view/5248heart failureacute decompensated heart failurepredictorstransthoracic echocardiographyimplantable cardioverter-defibrillator |
| spellingShingle | N. N. Ilov D. R. Stompel S. A. Boytsov O. V. Palnikova A. A. Nechepurenko Prediction of early mortality after cardioverter-defibrillator implantation for primary prevention of sudden cardiac death: focus on transthoracic echocardiography Российский кардиологический журнал heart failure acute decompensated heart failure predictors transthoracic echocardiography implantable cardioverter-defibrillator |
| title | Prediction of early mortality after cardioverter-defibrillator implantation for primary prevention of sudden cardiac death: focus on transthoracic echocardiography |
| title_full | Prediction of early mortality after cardioverter-defibrillator implantation for primary prevention of sudden cardiac death: focus on transthoracic echocardiography |
| title_fullStr | Prediction of early mortality after cardioverter-defibrillator implantation for primary prevention of sudden cardiac death: focus on transthoracic echocardiography |
| title_full_unstemmed | Prediction of early mortality after cardioverter-defibrillator implantation for primary prevention of sudden cardiac death: focus on transthoracic echocardiography |
| title_short | Prediction of early mortality after cardioverter-defibrillator implantation for primary prevention of sudden cardiac death: focus on transthoracic echocardiography |
| title_sort | prediction of early mortality after cardioverter defibrillator implantation for primary prevention of sudden cardiac death focus on transthoracic echocardiography |
| topic | heart failure acute decompensated heart failure predictors transthoracic echocardiography implantable cardioverter-defibrillator |
| url | https://russjcardiol.elpub.ru/jour/article/view/5248 |
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