Immunogenicity of Three Different Influenza Vaccines against Homologous and Heterologous Strains in Nursing Home Elderly Residents
We studied whether MF59-adjuvanted influenza vaccine improves immunity against drifted influenza strains in institutionalised elderly with underling chronic health conditions. Sera from a randomized study, comparing MF59-adjuvanted (Sub/MF59, n=72), virosomal (SVV, n=39), and split (n=88) vaccines,...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2010/517198 |
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| author | Vincenzo Baldo Tatjana Baldovin Michele Pellegrini Gabriele Angiolelli Silvia Majori Annarosa Floreani Marta Cecilia Busana Chiara Bertoncello Renzo Trivello |
| author_facet | Vincenzo Baldo Tatjana Baldovin Michele Pellegrini Gabriele Angiolelli Silvia Majori Annarosa Floreani Marta Cecilia Busana Chiara Bertoncello Renzo Trivello |
| author_sort | Vincenzo Baldo |
| collection | DOAJ |
| description | We studied whether MF59-adjuvanted influenza vaccine improves immunity against drifted influenza strains in institutionalised elderly with underling chronic health conditions. Sera from a randomized study, comparing MF59-adjuvanted (Sub/MF59, n=72), virosomal (SVV, n=39), and split (n=88) vaccines, were retested using a hemagglutination inhibition (HI) assay against homologous (Northern Hemisphere [NH] 1998/99) and drifted (NH 2006/07) strains. Corrected postvaccination HI antibody titres were significantly higher with Sub/MF59 than SVV for all strains; GMTs against homologous A/H3N2 and B and both drifted A strains were significantly higher for Sub/MF59 than split. Seroprotection rates and mean-fold titer increases were generally higher with Sub/MF59 for all A influenza strains. MF59-adjuvanted influenza vaccine induced greater and broader immune responses in elderly people with chronic conditions, than conventional virosomal and split vaccines, particularly for A/H1 and A/H3 strains, potentially giving clinical benefit in seasons where antigenic mismatch occurs. |
| format | Article |
| id | doaj-art-cdb037156364461fb4af2d23066a39e3 |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-cdb037156364461fb4af2d23066a39e32025-08-20T02:20:01ZengWileyClinical and Developmental Immunology1740-25221740-25302010-01-01201010.1155/2010/517198517198Immunogenicity of Three Different Influenza Vaccines against Homologous and Heterologous Strains in Nursing Home Elderly ResidentsVincenzo Baldo0Tatjana Baldovin1Michele Pellegrini2Gabriele Angiolelli3Silvia Majori4Annarosa Floreani5Marta Cecilia Busana6Chiara Bertoncello7Renzo Trivello8Department of Environmental Medicine and Public Health, Institute of Hygiene, University of Padua, Via loredan 18, 35151 Padua, ItalyDepartment of Environmental Medicine and Public Health, Institute of Hygiene, University of Padua, Via loredan 18, 35151 Padua, ItalyGlobal Clinical Research and Development, Novartis Vaccines & Diagnostics S.r.l., Via Fiorentina 1, 53100 Siena, ItalyLocal Health Unit n.13, Veneto Region, Via L. Mariutto, 76-30035 Mirano, ItalyDepartment of Medicine and Public Health, Section of Hygiene and Preventive, Environmental and Occupational Medicine, University of Verona, Strada Le Grazie, 8-37134 Verona, ItalyDepartment of Surgical and Gastroenterological Sciences, University of Padua, Via Giustiniani 2, 35100 Padua, ItalyDepartment of Environmental Medicine and Public Health, Institute of Hygiene, University of Padua, Via loredan 18, 35151 Padua, ItalyDepartment of Environmental Medicine and Public Health, Institute of Hygiene, University of Padua, Via loredan 18, 35151 Padua, ItalyDepartment of Environmental Medicine and Public Health, Institute of Hygiene, University of Padua, Via loredan 18, 35151 Padua, ItalyWe studied whether MF59-adjuvanted influenza vaccine improves immunity against drifted influenza strains in institutionalised elderly with underling chronic health conditions. Sera from a randomized study, comparing MF59-adjuvanted (Sub/MF59, n=72), virosomal (SVV, n=39), and split (n=88) vaccines, were retested using a hemagglutination inhibition (HI) assay against homologous (Northern Hemisphere [NH] 1998/99) and drifted (NH 2006/07) strains. Corrected postvaccination HI antibody titres were significantly higher with Sub/MF59 than SVV for all strains; GMTs against homologous A/H3N2 and B and both drifted A strains were significantly higher for Sub/MF59 than split. Seroprotection rates and mean-fold titer increases were generally higher with Sub/MF59 for all A influenza strains. MF59-adjuvanted influenza vaccine induced greater and broader immune responses in elderly people with chronic conditions, than conventional virosomal and split vaccines, particularly for A/H1 and A/H3 strains, potentially giving clinical benefit in seasons where antigenic mismatch occurs.http://dx.doi.org/10.1155/2010/517198 |
| spellingShingle | Vincenzo Baldo Tatjana Baldovin Michele Pellegrini Gabriele Angiolelli Silvia Majori Annarosa Floreani Marta Cecilia Busana Chiara Bertoncello Renzo Trivello Immunogenicity of Three Different Influenza Vaccines against Homologous and Heterologous Strains in Nursing Home Elderly Residents Clinical and Developmental Immunology |
| title | Immunogenicity of Three Different Influenza Vaccines against Homologous and Heterologous Strains in Nursing Home Elderly Residents |
| title_full | Immunogenicity of Three Different Influenza Vaccines against Homologous and Heterologous Strains in Nursing Home Elderly Residents |
| title_fullStr | Immunogenicity of Three Different Influenza Vaccines against Homologous and Heterologous Strains in Nursing Home Elderly Residents |
| title_full_unstemmed | Immunogenicity of Three Different Influenza Vaccines against Homologous and Heterologous Strains in Nursing Home Elderly Residents |
| title_short | Immunogenicity of Three Different Influenza Vaccines against Homologous and Heterologous Strains in Nursing Home Elderly Residents |
| title_sort | immunogenicity of three different influenza vaccines against homologous and heterologous strains in nursing home elderly residents |
| url | http://dx.doi.org/10.1155/2010/517198 |
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