Metformin versus insulin in gestational diabetes mellitus: a systematic review
Abstract Objective: The aim of this study is to assess the use of metformin with or without insulin for the treatment of Gestational Diabetes Mellitus compared to insulin alone. Data sources: This article consists of a systematic review of randomized clinical trials. The searches were carried out...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2025-01-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100323&lng=en&tlng=en |
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| Summary: | Abstract Objective: The aim of this study is to assess the use of metformin with or without insulin for the treatment of Gestational Diabetes Mellitus compared to insulin alone. Data sources: This article consists of a systematic review of randomized clinical trials. The searches were carried out on MEDLINE including 7 studies, between 2010 to 2021. Study selection: Randomized clinical trials comparing metformin and insulin written in English, Spanish or Portuguese, with no time limit, were included. Data collection: Data was extracted from all the 7 articles and compared statistically when possible. Whenever data was not available or couldn't be statistically compared, the main results were described in detail. Data synthesis: Insulin alone is not superior than metformin with or without insulin on gestational diabetes mellitus. Conclusion: There is a potential viability of using metformin as an alternative compared to insulin alone in the treatment of Gestational Diabetes Mellitus. However, all assessed outcomes have a very low level of certainty of evidence and more studies are necessary to support these findings. |
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| ISSN: | 0100-7203 |