Disruption of cholesterol homeostasis by antidepressants induces immunogenic cell death
Sertraline and indatraline are two antidepressants that function as serotonin reuptake inhibitors and have demonstrated promising anticancer potential, although their precise mechanisms of action remain unclear. Both compounds trigger cholesterol accumulation within lysosomes followed by lysosomal m...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | OncoImmunology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2025.2531113 |
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| author | Karla Alvarez-Valadez Jonathan G. Pol Guido Kroemer Mojgan Djavaheri-Mergny |
| author_facet | Karla Alvarez-Valadez Jonathan G. Pol Guido Kroemer Mojgan Djavaheri-Mergny |
| author_sort | Karla Alvarez-Valadez |
| collection | DOAJ |
| description | Sertraline and indatraline are two antidepressants that function as serotonin reuptake inhibitors and have demonstrated promising anticancer potential, although their precise mechanisms of action remain unclear. Both compounds trigger cholesterol accumulation within lysosomes followed by lysosomal membrane permeabilization, ultimately leading to the activation of immunogenic cell death (ICD). This, in turn, triggers a T cell-mediated adaptive immune response that facilitates significant tumor control. |
| format | Article |
| id | doaj-art-cd9cace911574c72bef9cb270e1cc7c6 |
| institution | Kabale University |
| issn | 2162-402X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj-art-cd9cace911574c72bef9cb270e1cc7c62025-08-20T03:50:07ZengTaylor & Francis GroupOncoImmunology2162-402X2025-12-0114110.1080/2162402X.2025.2531113Disruption of cholesterol homeostasis by antidepressants induces immunogenic cell deathKarla Alvarez-Valadez0Jonathan G. Pol1Guido Kroemer2Mojgan Djavaheri-Mergny3Centre de Recherche des Cordeliers, Inserm UMRS 1138, Sorbonne Université, Université de Paris Cité, Équipe labellisée par la Ligue contre le Cancer, Institut Universitaire de France, Paris, FranceCentre de Recherche des Cordeliers, Inserm UMRS 1138, Sorbonne Université, Université de Paris Cité, Équipe labellisée par la Ligue contre le Cancer, Institut Universitaire de France, Paris, FranceCentre de Recherche des Cordeliers, Inserm UMRS 1138, Sorbonne Université, Université de Paris Cité, Équipe labellisée par la Ligue contre le Cancer, Institut Universitaire de France, Paris, FranceCentre de Recherche des Cordeliers, Inserm UMRS 1138, Sorbonne Université, Université de Paris Cité, Équipe labellisée par la Ligue contre le Cancer, Institut Universitaire de France, Paris, FranceSertraline and indatraline are two antidepressants that function as serotonin reuptake inhibitors and have demonstrated promising anticancer potential, although their precise mechanisms of action remain unclear. Both compounds trigger cholesterol accumulation within lysosomes followed by lysosomal membrane permeabilization, ultimately leading to the activation of immunogenic cell death (ICD). This, in turn, triggers a T cell-mediated adaptive immune response that facilitates significant tumor control.https://www.tandfonline.com/doi/10.1080/2162402X.2025.2531113Antitumor immunitycancercholesterol transportlysosomeserotonin reuptake inhibitors, TFEB |
| spellingShingle | Karla Alvarez-Valadez Jonathan G. Pol Guido Kroemer Mojgan Djavaheri-Mergny Disruption of cholesterol homeostasis by antidepressants induces immunogenic cell death OncoImmunology Antitumor immunity cancer cholesterol transport lysosome serotonin reuptake inhibitors, TFEB |
| title | Disruption of cholesterol homeostasis by antidepressants induces immunogenic cell death |
| title_full | Disruption of cholesterol homeostasis by antidepressants induces immunogenic cell death |
| title_fullStr | Disruption of cholesterol homeostasis by antidepressants induces immunogenic cell death |
| title_full_unstemmed | Disruption of cholesterol homeostasis by antidepressants induces immunogenic cell death |
| title_short | Disruption of cholesterol homeostasis by antidepressants induces immunogenic cell death |
| title_sort | disruption of cholesterol homeostasis by antidepressants induces immunogenic cell death |
| topic | Antitumor immunity cancer cholesterol transport lysosome serotonin reuptake inhibitors, TFEB |
| url | https://www.tandfonline.com/doi/10.1080/2162402X.2025.2531113 |
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