Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model
Establishment of small animal models of Ebola virus (EBOV) infection is important both for the study of genetic determinants involved in the complex pathology of EBOV disease and for the preliminary screening of antivirals, production of therapeutic heterologic immunoglobulins, and experimental vacc...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2016/8059607 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849695993218465792 |
|---|---|
| author | S. V. Cheresiz E. A. Semenova A. A. Chepurnov |
| author_facet | S. V. Cheresiz E. A. Semenova A. A. Chepurnov |
| author_sort | S. V. Cheresiz |
| collection | DOAJ |
| description | Establishment of small animal models of Ebola virus (EBOV) infection is important both for the study of genetic determinants involved in the complex pathology of EBOV disease and for the preliminary screening of antivirals, production of therapeutic heterologic immunoglobulins, and experimental vaccine development. Since the wild-type EBOV is avirulent in rodents, the adaptation series of passages in these animals are required for the virulence/lethality to emerge in these models. Here, we provide an overview of our several adaptation series in guinea pigs, which resulted in the establishment of guinea pig-adapted EBOV (GPA-EBOV) variants different in their characteristics, while uniformly lethal for the infected animals, and compare the virologic, genetic, pathomorphologic, and immunologic findings with those obtained in the adaptation experiments of the other research groups. |
| format | Article |
| id | doaj-art-cd966a13ccae4a64907df66ad44a7aee |
| institution | DOAJ |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-cd966a13ccae4a64907df66ad44a7aee2025-08-20T03:19:35ZengWileyAdvances in Virology1687-86391687-86472016-01-01201610.1155/2016/80596078059607Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection ModelS. V. Cheresiz0E. A. Semenova1A. A. Chepurnov2Department of Medicine, Novosibirsk State University, Pirogova Street 2, 630090 Novosibirsk-90, RussiaDepartment of Medicine, Novosibirsk State University, Pirogova Street 2, 630090 Novosibirsk-90, RussiaInstitute of Clinical Immunology, Yadrincevskaya Street 14, 630047 Novosibirsk-47, RussiaEstablishment of small animal models of Ebola virus (EBOV) infection is important both for the study of genetic determinants involved in the complex pathology of EBOV disease and for the preliminary screening of antivirals, production of therapeutic heterologic immunoglobulins, and experimental vaccine development. Since the wild-type EBOV is avirulent in rodents, the adaptation series of passages in these animals are required for the virulence/lethality to emerge in these models. Here, we provide an overview of our several adaptation series in guinea pigs, which resulted in the establishment of guinea pig-adapted EBOV (GPA-EBOV) variants different in their characteristics, while uniformly lethal for the infected animals, and compare the virologic, genetic, pathomorphologic, and immunologic findings with those obtained in the adaptation experiments of the other research groups.http://dx.doi.org/10.1155/2016/8059607 |
| spellingShingle | S. V. Cheresiz E. A. Semenova A. A. Chepurnov Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model Advances in Virology |
| title | Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model |
| title_full | Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model |
| title_fullStr | Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model |
| title_full_unstemmed | Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model |
| title_short | Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model |
| title_sort | adapted lethality what we can learn from guinea pig adapted ebola virus infection model |
| url | http://dx.doi.org/10.1155/2016/8059607 |
| work_keys_str_mv | AT svcheresiz adaptedlethalitywhatwecanlearnfromguineapigadaptedebolavirusinfectionmodel AT easemenova adaptedlethalitywhatwecanlearnfromguineapigadaptedebolavirusinfectionmodel AT aachepurnov adaptedlethalitywhatwecanlearnfromguineapigadaptedebolavirusinfectionmodel |