Airway basal stem cell therapy for lung diseases: an emerging regenerative medicine strategy
Abstract Chronic pulmonary diseases pose a prominent health threat globally owing to their intricate pathogenesis and lack of effective reversal therapies. Nowadays, lung transplantation stands out as a feasible treatment option for patients with end-stage lung disease. Unfortunately, the use of thi...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-025-04152-5 |
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| author | Xingren Liu Xin Wang Xue Wu Shuhua Zhan Yan Yang Caiyu Jiang |
| author_facet | Xingren Liu Xin Wang Xue Wu Shuhua Zhan Yan Yang Caiyu Jiang |
| author_sort | Xingren Liu |
| collection | DOAJ |
| description | Abstract Chronic pulmonary diseases pose a prominent health threat globally owing to their intricate pathogenesis and lack of effective reversal therapies. Nowadays, lung transplantation stands out as a feasible treatment option for patients with end-stage lung disease. Unfortunately, the use of this this option is limited by donor organ shortage and severe immunological rejection reactions. Recently, airway basal stem cells (BSCs) have emerged as a novel therapeutic strategy in pulmonary regenerative medicine because of their substantial potential in repairing lung structure and function. Airway BSCs, which are strongly capable of self-renewal and multi-lineage differentiation, can effectively attenuate airway epithelial injury caused by environmental factors or genetic disorders, such as cystic fibrosis. This review comprehensively explores the efficacy and action mechanisms of airway BSCs across various lung disease models and describes potential strategies for inducing pluripotent stem cells to differentiate into pulmonary epithelial lineages on the basis of the original research findings. Additionally, the review also discusses the technical and biological challenges in translating these research findings into clinical applications and offers prospective views on future research directions, therefore broadening the landscape of pulmonary regenerative medicine. |
| format | Article |
| id | doaj-art-cd962be6b8054202b7eb040355fd2921 |
| institution | Kabale University |
| issn | 1757-6512 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-cd962be6b8054202b7eb040355fd29212025-02-02T12:11:24ZengBMCStem Cell Research & Therapy1757-65122025-01-0116111110.1186/s13287-025-04152-5Airway basal stem cell therapy for lung diseases: an emerging regenerative medicine strategyXingren Liu0Xin Wang1Xue Wu2Shuhua Zhan3Yan Yang4Caiyu Jiang5Department of Pulmonary and Critical Care Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Emergency, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Pulmonary and Critical Care Medicine, Bazhong Enyang District People’s HospitalDepartment of Pulmonary and Critical Care Medicine, Aba Tibetan and Qiang Autonomous Prefecture People’s HospitalDepartment of Pulmonary and Critical Care Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Pulmonary and Critical Care Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaAbstract Chronic pulmonary diseases pose a prominent health threat globally owing to their intricate pathogenesis and lack of effective reversal therapies. Nowadays, lung transplantation stands out as a feasible treatment option for patients with end-stage lung disease. Unfortunately, the use of this this option is limited by donor organ shortage and severe immunological rejection reactions. Recently, airway basal stem cells (BSCs) have emerged as a novel therapeutic strategy in pulmonary regenerative medicine because of their substantial potential in repairing lung structure and function. Airway BSCs, which are strongly capable of self-renewal and multi-lineage differentiation, can effectively attenuate airway epithelial injury caused by environmental factors or genetic disorders, such as cystic fibrosis. This review comprehensively explores the efficacy and action mechanisms of airway BSCs across various lung disease models and describes potential strategies for inducing pluripotent stem cells to differentiate into pulmonary epithelial lineages on the basis of the original research findings. Additionally, the review also discusses the technical and biological challenges in translating these research findings into clinical applications and offers prospective views on future research directions, therefore broadening the landscape of pulmonary regenerative medicine.https://doi.org/10.1186/s13287-025-04152-5Airway basal stem cellsAirway epitheliumLung diseasesRegenerative medicineEpithelial repairPluripotent stem cells |
| spellingShingle | Xingren Liu Xin Wang Xue Wu Shuhua Zhan Yan Yang Caiyu Jiang Airway basal stem cell therapy for lung diseases: an emerging regenerative medicine strategy Stem Cell Research & Therapy Airway basal stem cells Airway epithelium Lung diseases Regenerative medicine Epithelial repair Pluripotent stem cells |
| title | Airway basal stem cell therapy for lung diseases: an emerging regenerative medicine strategy |
| title_full | Airway basal stem cell therapy for lung diseases: an emerging regenerative medicine strategy |
| title_fullStr | Airway basal stem cell therapy for lung diseases: an emerging regenerative medicine strategy |
| title_full_unstemmed | Airway basal stem cell therapy for lung diseases: an emerging regenerative medicine strategy |
| title_short | Airway basal stem cell therapy for lung diseases: an emerging regenerative medicine strategy |
| title_sort | airway basal stem cell therapy for lung diseases an emerging regenerative medicine strategy |
| topic | Airway basal stem cells Airway epithelium Lung diseases Regenerative medicine Epithelial repair Pluripotent stem cells |
| url | https://doi.org/10.1186/s13287-025-04152-5 |
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