MG132 Ameliorates Kidney Lesions by Inhibiting the Degradation of Smad7 in Streptozotocin-Induced Diabetic Nephropathy

MG132 Ameliorates Kidney Lesions by Inhibiting the Degradation of Smad7 in Streptozotocin-Induced Diabetic Nephropathy

Background. Smad7 is the main negative regulatory protein in the transforming growth factor-β (TGF-β) downstream signaling pathway, which plays an important role in diabetic nephropathy (DN) and may be related to the ubiquitin proteasome pathway (UPP). Aim. We investigated the role of UPP in regulat...

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Bibliographic Details
Main Authors:	Chenlin Gao, Keri Aqie, Jianhua Zhu, Guo Chen, Ling Xu, Lan Jiang, Yong Xu
Format:	Article
Language:	English
Published:	Wiley 2014-01-01
Series:	Journal of Diabetes Research
Online Access:	http://dx.doi.org/10.1155/2014/918396
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