Targeting YY1-DR5 Axis by Pyripyropene O as a Novel Therapeutic Strategy Against Prostate Cancer: Molecular Mechanisms and In Vivo Zebrafish Validation

Targeting YY1-DR5 Axis by Pyripyropene O as a Novel Therapeutic Strategy Against Prostate Cancer: Molecular Mechanisms and In Vivo Zebrafish Validation

Background: Induction of apoptosis is an important strategy for the treatment of prostate cancer. DR5 is a member of the death receptor superfamily and targeting DR5 is an effective way to induce apoptosis. Pyripyropene O is a natural compound isolated from the marine fungus <i>Aspergillus fum...

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Bibliographic Details
Main Authors: Wenxuan Fang, Ying Chen, Mingyi Nie, Xuefeng Zhou, Yonghong Liu, Huaming Tao, Bin Yang, Xueni Wang
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Marine Drugs
Subjects:
pyripyropene O
prostate cancer
apoptosis
Ying Yang 1
death receptor 5
Online Access:https://www.mdpi.com/1660-3397/23/5/214
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