Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy
Prostaglandin E2 (PGE2) is an endogenous lipid mediator, produced from the metabolism of arachidonic acids, upon the sequential actions of phospholipase A2, cyclooxygenases, and prostaglandin E synthases. The various biological functions governed by PGE2 are mediated through its four distinct prosta...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/1324347 |
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| author | Lei Pang Yin Cai Eva Hoi Ching Tang Michael G. Irwin Haichun Ma Zhengyuan Xia |
| author_facet | Lei Pang Yin Cai Eva Hoi Ching Tang Michael G. Irwin Haichun Ma Zhengyuan Xia |
| author_sort | Lei Pang |
| collection | DOAJ |
| description | Prostaglandin E2 (PGE2) is an endogenous lipid mediator, produced from the metabolism of arachidonic acids, upon the sequential actions of phospholipase A2, cyclooxygenases, and prostaglandin E synthases. The various biological functions governed by PGE2 are mediated through its four distinct prostaglandin E receptors (EPs), designated as EP1, EP2, EP3, and EP4, among which the EP4 receptor is the one most widely distributed in the heart. The availability of global or cardiac-specific EP4 knockout mice and the development of selective EP4 agonists/antagonists have provided substantial evidence to support the role of EP4 receptor in the heart. However, like any good drama, activation of PGE2-EP4 signaling exerts both protective and detrimental effects in the ischemic heart disease. Thus, the primary object of this review is to provide a comprehensive overview of the current progress of the PGE2-EP4 signaling in ischemic heart diseases, including cardiac hypertrophy and myocardial ischemia/reperfusion injury. A better understanding of PGE2-EP4 signaling should promote the development of more effective therapeutic approaches to treat the ischemic heart diseases without triggering unwanted side effects. |
| format | Article |
| id | doaj-art-cd8bccebb52642bdb3a1054af24a3a5d |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-cd8bccebb52642bdb3a1054af24a3a5d2025-08-20T02:19:54ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/13243471324347Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac HypertrophyLei Pang0Yin Cai1Eva Hoi Ching Tang2Michael G. Irwin3Haichun Ma4Zhengyuan Xia5Department of Anesthesiology, The First Hospital, Jilin University, Jilin 130021, ChinaDepartment of Anesthesiology, The University of Hong Kong, Pokfulam, Hong KongDepartment of Pharmacology and Pharmacy and State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pokfulam, Hong KongDepartment of Anesthesiology, The University of Hong Kong, Pokfulam, Hong KongDepartment of Anesthesiology, The First Hospital, Jilin University, Jilin 130021, ChinaDepartment of Anesthesiology, The University of Hong Kong, Pokfulam, Hong KongProstaglandin E2 (PGE2) is an endogenous lipid mediator, produced from the metabolism of arachidonic acids, upon the sequential actions of phospholipase A2, cyclooxygenases, and prostaglandin E synthases. The various biological functions governed by PGE2 are mediated through its four distinct prostaglandin E receptors (EPs), designated as EP1, EP2, EP3, and EP4, among which the EP4 receptor is the one most widely distributed in the heart. The availability of global or cardiac-specific EP4 knockout mice and the development of selective EP4 agonists/antagonists have provided substantial evidence to support the role of EP4 receptor in the heart. However, like any good drama, activation of PGE2-EP4 signaling exerts both protective and detrimental effects in the ischemic heart disease. Thus, the primary object of this review is to provide a comprehensive overview of the current progress of the PGE2-EP4 signaling in ischemic heart diseases, including cardiac hypertrophy and myocardial ischemia/reperfusion injury. A better understanding of PGE2-EP4 signaling should promote the development of more effective therapeutic approaches to treat the ischemic heart diseases without triggering unwanted side effects.http://dx.doi.org/10.1155/2016/1324347 |
| spellingShingle | Lei Pang Yin Cai Eva Hoi Ching Tang Michael G. Irwin Haichun Ma Zhengyuan Xia Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy Journal of Diabetes Research |
| title | Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy |
| title_full | Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy |
| title_fullStr | Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy |
| title_full_unstemmed | Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy |
| title_short | Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy |
| title_sort | prostaglandin e receptor subtype 4 signaling in the heart role in ischemia reperfusion injury and cardiac hypertrophy |
| url | http://dx.doi.org/10.1155/2016/1324347 |
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