Peripheral disease contributes significantly to the level of disease activity in axial spondyloarthritis
Objective Spondyloarthritis (SpA) can encompass axial, peripheral and extra-articular disease manifestations. Patients are classified as axial or peripheral SpA depending on the presence or absence of current back pain, independently of the other disease manifestations. Therefore, we aimed to assess...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2019-06-01
|
| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/5/1/e000802.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849469633554284544 |
|---|---|
| author | Janneke J de Winter Jacqueline E Paramarta Henriëtte M de Jong Marleen G van de Sande Dominique L Baeten |
| author_facet | Janneke J de Winter Jacqueline E Paramarta Henriëtte M de Jong Marleen G van de Sande Dominique L Baeten |
| author_sort | Janneke J de Winter |
| collection | DOAJ |
| description | Objective Spondyloarthritis (SpA) can encompass axial, peripheral and extra-articular disease manifestations. Patients are classified as axial or peripheral SpA depending on the presence or absence of current back pain, independently of the other disease manifestations. Therefore, we aimed to assess the percentage of patients with axial SpA with peripheral disease and how this peripheral disease contributes to the overall disease activity.Methods Prevalence and disease activity of peripheral disease manifestations were assessed in a real-life observational cohort of 314 patients with the clinical diagnosis of SpA and fulfilling the Assessment of SpondyloArthritis international Society (ASAS) criteria.Results Of the 314 patients fulfilling the ASAS criteria, 230 fulfilled the axial and 84 the peripheral SpA criteria. Of the 230 patients with axial SpA, 49% had purely axial disease without peripheral disease manifestations whereas 51% had combined axial (back pain) and peripheral (arthritis, enthesitis and/or dactylitis) disease. The latter group had the highest disease activity in comparison with pure axial SpA as well as with peripheral SpA.Conclusion Half of the patients classified as axial SpA according to the ASAS criteria also have peripheral disease manifestations such as arthritis, enthesitis and/or dactylitis. These peripheral disease manifestations contribute significantly to overall disease activity. |
| format | Article |
| id | doaj-art-cd85faa4b4a44b5a81751e5a59777971 |
| institution | Kabale University |
| issn | 2056-5933 |
| language | English |
| publishDate | 2019-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj-art-cd85faa4b4a44b5a81751e5a597779712025-08-20T03:25:25ZengBMJ Publishing GroupRMD Open2056-59332019-06-015110.1136/rmdopen-2018-000802Peripheral disease contributes significantly to the level of disease activity in axial spondyloarthritisJanneke J de Winter0Jacqueline E Paramarta1Henriëtte M de Jong2Marleen G van de Sande3Dominique L Baeten4Amsterdam Rheumatology and Immunology Center, Department of Clinical Immunology and Rheumatology, Amsterdam UMC University of Amsterdam, Amsterdam, The NetherlandsAmsterdam Rheumatology and Immunology Center, Department of Clinical Immunology and Rheumatology, Amsterdam UMC University of Amsterdam, Amsterdam, The NetherlandsAmsterdam Rheumatology and Immunology Center, Department of Clinical Immunology and Rheumatology, Amsterdam UMC University of Amsterdam, Amsterdam, The NetherlandsAmsterdam Rheumatology and Immunology Center, Department of Clinical Immunology and Rheumatology, Amsterdam UMC University of Amsterdam, Amsterdam, The NetherlandsAmsterdam Rheumatology and Immunology Center, Department of Clinical Immunology and Rheumatology, Amsterdam UMC University of Amsterdam, Amsterdam, The NetherlandsObjective Spondyloarthritis (SpA) can encompass axial, peripheral and extra-articular disease manifestations. Patients are classified as axial or peripheral SpA depending on the presence or absence of current back pain, independently of the other disease manifestations. Therefore, we aimed to assess the percentage of patients with axial SpA with peripheral disease and how this peripheral disease contributes to the overall disease activity.Methods Prevalence and disease activity of peripheral disease manifestations were assessed in a real-life observational cohort of 314 patients with the clinical diagnosis of SpA and fulfilling the Assessment of SpondyloArthritis international Society (ASAS) criteria.Results Of the 314 patients fulfilling the ASAS criteria, 230 fulfilled the axial and 84 the peripheral SpA criteria. Of the 230 patients with axial SpA, 49% had purely axial disease without peripheral disease manifestations whereas 51% had combined axial (back pain) and peripheral (arthritis, enthesitis and/or dactylitis) disease. The latter group had the highest disease activity in comparison with pure axial SpA as well as with peripheral SpA.Conclusion Half of the patients classified as axial SpA according to the ASAS criteria also have peripheral disease manifestations such as arthritis, enthesitis and/or dactylitis. These peripheral disease manifestations contribute significantly to overall disease activity.https://rmdopen.bmj.com/content/5/1/e000802.full |
| spellingShingle | Janneke J de Winter Jacqueline E Paramarta Henriëtte M de Jong Marleen G van de Sande Dominique L Baeten Peripheral disease contributes significantly to the level of disease activity in axial spondyloarthritis RMD Open |
| title | Peripheral disease contributes significantly to the level of disease activity in axial spondyloarthritis |
| title_full | Peripheral disease contributes significantly to the level of disease activity in axial spondyloarthritis |
| title_fullStr | Peripheral disease contributes significantly to the level of disease activity in axial spondyloarthritis |
| title_full_unstemmed | Peripheral disease contributes significantly to the level of disease activity in axial spondyloarthritis |
| title_short | Peripheral disease contributes significantly to the level of disease activity in axial spondyloarthritis |
| title_sort | peripheral disease contributes significantly to the level of disease activity in axial spondyloarthritis |
| url | https://rmdopen.bmj.com/content/5/1/e000802.full |
| work_keys_str_mv | AT jannekejdewinter peripheraldiseasecontributessignificantlytothelevelofdiseaseactivityinaxialspondyloarthritis AT jacquelineeparamarta peripheraldiseasecontributessignificantlytothelevelofdiseaseactivityinaxialspondyloarthritis AT henriettemdejong peripheraldiseasecontributessignificantlytothelevelofdiseaseactivityinaxialspondyloarthritis AT marleengvandesande peripheraldiseasecontributessignificantlytothelevelofdiseaseactivityinaxialspondyloarthritis AT dominiquelbaeten peripheraldiseasecontributessignificantlytothelevelofdiseaseactivityinaxialspondyloarthritis |