Global trends in chronic kidney disease mortality and disability-adjusted life years attributable to low physical activity (1990–2021): a growing public health challenge
Abstract Background Low physical activity (LPA) is a major contributor to the global burden of chronic kidney disease (CKD). Our goal was to assess the spatiotemporal trends in the CKD burden attributable to LPA from 1990 to 2021, with a focus on the globe, China, five SDI regions, and four continen...
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BMC
2025-04-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-025-04117-z |
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| author | ZhenYi Zhao Jing Mi HaoDong Jin ShuaiRan Li Xia Bai |
| author_facet | ZhenYi Zhao Jing Mi HaoDong Jin ShuaiRan Li Xia Bai |
| author_sort | ZhenYi Zhao |
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| description | Abstract Background Low physical activity (LPA) is a major contributor to the global burden of chronic kidney disease (CKD). Our goal was to assess the spatiotemporal trends in the CKD burden attributable to LPA from 1990 to 2021, with a focus on the globe, China, five SDI regions, and four continents. Methods We analysed CKD-related deaths, DALYs, the ASMR, the ASDR, and the EAPC attributable to low physical activity (LPA). This study focused on trends from 1990 to 2021 across the globe, China, five SDI regions, and four continents. Decomposition analysis, frontier analysis, and forecasting models were employed to explore changes in these indicators and their influencing factors. Results In 2021, CKD attributable to low physical activity (LPA) resulted in 913,070 [95% UI: 348,170–1,619,770] DALYs and 40,920 [95% UI: 16,170–72,560] deaths globally, both of which were higher than those reported in 1990. The AOSD increased from 9.63 (95% UI: 3.73–17.02) to 10.81 (95% UI: 4.14–19.18) per 100,000, with an EAPC of 0.42 (95% CI: 0.35–0.48). The ASMR increased from 0.42 (95% UI: 0.17–0.74) to 0.50 (95% UI: 0.20–0.90) per 100,000, with an EAPC of 0.65 (95% CI: 0.57–0.73). The burden was greater among females, with more rapid increases in the ASDR and ASMR. The Americas and high-SDI regions presented the greatest growth in DALY and mortality rates. Conclusions The burden of CKD attributable to low physical activity (LPA) has increased significantly, particularly in low-SDI regions, women, and elderly individuals. The findings highlight the importance of promoting physical activity and implementing early interventions to inform public health policies. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-cd7d32e2b99344aa8c824471bc9d9ae8 |
| institution | OA Journals |
| issn | 1471-2369 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj-art-cd7d32e2b99344aa8c824471bc9d9ae82025-08-20T02:10:54ZengBMCBMC Nephrology1471-23692025-04-0126111810.1186/s12882-025-04117-zGlobal trends in chronic kidney disease mortality and disability-adjusted life years attributable to low physical activity (1990–2021): a growing public health challengeZhenYi Zhao0Jing Mi1HaoDong Jin2ShuaiRan Li3Xia Bai4School of Competitive Sports, Beijing Sport UniversitySchool of Competitive Sports, Beijing Sport UniversitySchool of Competitive Sports, Beijing Sport UniversitySchool of Competitive Sports, Beijing Sport UniversitySchool of Competitive Sports, Beijing Sport UniversityAbstract Background Low physical activity (LPA) is a major contributor to the global burden of chronic kidney disease (CKD). Our goal was to assess the spatiotemporal trends in the CKD burden attributable to LPA from 1990 to 2021, with a focus on the globe, China, five SDI regions, and four continents. Methods We analysed CKD-related deaths, DALYs, the ASMR, the ASDR, and the EAPC attributable to low physical activity (LPA). This study focused on trends from 1990 to 2021 across the globe, China, five SDI regions, and four continents. Decomposition analysis, frontier analysis, and forecasting models were employed to explore changes in these indicators and their influencing factors. Results In 2021, CKD attributable to low physical activity (LPA) resulted in 913,070 [95% UI: 348,170–1,619,770] DALYs and 40,920 [95% UI: 16,170–72,560] deaths globally, both of which were higher than those reported in 1990. The AOSD increased from 9.63 (95% UI: 3.73–17.02) to 10.81 (95% UI: 4.14–19.18) per 100,000, with an EAPC of 0.42 (95% CI: 0.35–0.48). The ASMR increased from 0.42 (95% UI: 0.17–0.74) to 0.50 (95% UI: 0.20–0.90) per 100,000, with an EAPC of 0.65 (95% CI: 0.57–0.73). The burden was greater among females, with more rapid increases in the ASDR and ASMR. The Americas and high-SDI regions presented the greatest growth in DALY and mortality rates. Conclusions The burden of CKD attributable to low physical activity (LPA) has increased significantly, particularly in low-SDI regions, women, and elderly individuals. The findings highlight the importance of promoting physical activity and implementing early interventions to inform public health policies. Clinical trial number Not applicable.https://doi.org/10.1186/s12882-025-04117-zLow physical activityChronic kidney diseaseDisease burdenDisability-adjusted life yearsMortalitySocio-Demographic index |
| spellingShingle | ZhenYi Zhao Jing Mi HaoDong Jin ShuaiRan Li Xia Bai Global trends in chronic kidney disease mortality and disability-adjusted life years attributable to low physical activity (1990–2021): a growing public health challenge BMC Nephrology Low physical activity Chronic kidney disease Disease burden Disability-adjusted life years Mortality Socio-Demographic index |
| title | Global trends in chronic kidney disease mortality and disability-adjusted life years attributable to low physical activity (1990–2021): a growing public health challenge |
| title_full | Global trends in chronic kidney disease mortality and disability-adjusted life years attributable to low physical activity (1990–2021): a growing public health challenge |
| title_fullStr | Global trends in chronic kidney disease mortality and disability-adjusted life years attributable to low physical activity (1990–2021): a growing public health challenge |
| title_full_unstemmed | Global trends in chronic kidney disease mortality and disability-adjusted life years attributable to low physical activity (1990–2021): a growing public health challenge |
| title_short | Global trends in chronic kidney disease mortality and disability-adjusted life years attributable to low physical activity (1990–2021): a growing public health challenge |
| title_sort | global trends in chronic kidney disease mortality and disability adjusted life years attributable to low physical activity 1990 2021 a growing public health challenge |
| topic | Low physical activity Chronic kidney disease Disease burden Disability-adjusted life years Mortality Socio-Demographic index |
| url | https://doi.org/10.1186/s12882-025-04117-z |
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