Autism-like phenotype across the lifespan of Shank3B-mutant mice of both sexes

Autism-like phenotype across the lifespan of Shank3B-mutant mice of both sexes

Abstract Background High heritability (80–90%) of the autism spectrum disorder (ASD) and sex-biased incidence (3–4 times more boys than girls) suggest the roles of genetic predisposition and sex in the etiopathogenesis of the disorder. As ASD is commonly diagnosed in early childhood, most of the res...

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Bibliographic Details
Main Authors: Jakub Szabó, Johan Filo, Rebeka Démuthová, Emese Renczés, Veronika Borbélyová, Daniela Ostatníková, Peter Celec
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Neurodevelopmental Disorders
Subjects:
Animal model
Phelan-McDermid syndrome
Phenotyping
Symptom development
Online Access:https://doi.org/10.1186/s11689-025-09635-3
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