THE ONSET OF ANCA-ASSOCIATED SYSTEMIC VASCULITIS MASKING RHEUMATOID ARTHRITIS
The paper describes a case of microscopic polyangiitis (MPA), the first clinical manifestation of which has been joint damage characterized chiefly by arthralgias. The overproduction of rheumatoid factor and anticyclic citrullinated peptide antibodies served as the basis for assuming rheumatoid arth...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2016-02-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2158 |
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| author | N. F. Frolova L. V. Korsakova E. S. Stolyarevich N. O. Nikonorova T. V. Beketova |
| author_facet | N. F. Frolova L. V. Korsakova E. S. Stolyarevich N. O. Nikonorova T. V. Beketova |
| author_sort | N. F. Frolova |
| collection | DOAJ |
| description | The paper describes a case of microscopic polyangiitis (MPA), the first clinical manifestation of which has been joint damage characterized chiefly by arthralgias. The overproduction of rheumatoid factor and anticyclic citrullinated peptide antibodies served as the basis for assuming rheumatoid arthritis (RA). Two years after disease onset, there were the first signs of glomerulonephritis (GN) that further progressed to severe kidney failure. MPA was diagnosed by a renal biopsy that revealed the morphological pattern of immunonegative GN with glomerular crescents. The diagnosis was verified by the presence of serum antineutrophil cytoplasmic antibodies (ANCA). There were no X-ray bone changes typical for RA at a 10-year follow-up. The paper discusses whether it is important to incorporate ANCA-associated systemic vasculitis into a diagnostic search in patients with early arthritis, particularly when the latter is concurrent with involvement of the kidney or other organs. |
| format | Article |
| id | doaj-art-cd76f5ac650a4b6096da8f9b0eb37822 |
| institution | Kabale University |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-cd76f5ac650a4b6096da8f9b0eb378222025-08-20T04:00:41ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922016-02-0153665365610.14412/1995-4484-2015-633-6562038THE ONSET OF ANCA-ASSOCIATED SYSTEMIC VASCULITIS MASKING RHEUMATOID ARTHRITISN. F. Frolova0L. V. Korsakova1E. S. Stolyarevich2N. O. Nikonorova3T. V. Beketova4City Clinical Hospital Fifty-Two, Moscow, Russia 3, Pekhotnaya St., Moscow 123182City Clinical Hospital Fifty-Two, Moscow, Russia 3, Pekhotnaya St., Moscow 123182City Clinical Hospital Fifty-Two, Moscow, Russia 3, Pekhotnaya St., Moscow 123182V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia 34A, Kashirskoe Shosse, Moscow 115522V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia 34A, Kashirskoe Shosse, Moscow 115522The paper describes a case of microscopic polyangiitis (MPA), the first clinical manifestation of which has been joint damage characterized chiefly by arthralgias. The overproduction of rheumatoid factor and anticyclic citrullinated peptide antibodies served as the basis for assuming rheumatoid arthritis (RA). Two years after disease onset, there were the first signs of glomerulonephritis (GN) that further progressed to severe kidney failure. MPA was diagnosed by a renal biopsy that revealed the morphological pattern of immunonegative GN with glomerular crescents. The diagnosis was verified by the presence of serum antineutrophil cytoplasmic antibodies (ANCA). There were no X-ray bone changes typical for RA at a 10-year follow-up. The paper discusses whether it is important to incorporate ANCA-associated systemic vasculitis into a diagnostic search in patients with early arthritis, particularly when the latter is concurrent with involvement of the kidney or other organs.https://rsp.mediar-press.net/rsp/article/view/2158systemic vasculitisantineutrophil cytoplasmic antibodiesmicroscopic polyangiitisgranulomatosis with polyangiitisrheumatoid arthritisanticyclic citrullinated peptide antibodies |
| spellingShingle | N. F. Frolova L. V. Korsakova E. S. Stolyarevich N. O. Nikonorova T. V. Beketova THE ONSET OF ANCA-ASSOCIATED SYSTEMIC VASCULITIS MASKING RHEUMATOID ARTHRITIS Научно-практическая ревматология systemic vasculitis antineutrophil cytoplasmic antibodies microscopic polyangiitis granulomatosis with polyangiitis rheumatoid arthritis anticyclic citrullinated peptide antibodies |
| title | THE ONSET OF ANCA-ASSOCIATED SYSTEMIC VASCULITIS MASKING RHEUMATOID ARTHRITIS |
| title_full | THE ONSET OF ANCA-ASSOCIATED SYSTEMIC VASCULITIS MASKING RHEUMATOID ARTHRITIS |
| title_fullStr | THE ONSET OF ANCA-ASSOCIATED SYSTEMIC VASCULITIS MASKING RHEUMATOID ARTHRITIS |
| title_full_unstemmed | THE ONSET OF ANCA-ASSOCIATED SYSTEMIC VASCULITIS MASKING RHEUMATOID ARTHRITIS |
| title_short | THE ONSET OF ANCA-ASSOCIATED SYSTEMIC VASCULITIS MASKING RHEUMATOID ARTHRITIS |
| title_sort | onset of anca associated systemic vasculitis masking rheumatoid arthritis |
| topic | systemic vasculitis antineutrophil cytoplasmic antibodies microscopic polyangiitis granulomatosis with polyangiitis rheumatoid arthritis anticyclic citrullinated peptide antibodies |
| url | https://rsp.mediar-press.net/rsp/article/view/2158 |
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