Contemporary trends in global mortality of sepsis among young infants less than 90 days old: protocol for a systematic review and meta-analysis
Introduction Neonatal sepsis has a high mortality rate that varies across different populations. We aim to perform a contemporary global evidence synthesis to determine the case fatality rates of neonatal sepsis, in order to better delineate this public health urgency and inform strategies to reduce...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-07-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/7/e038815.full |
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| author | Jen Heng Pek Shu-Ling Chong Bei Jun Yap Ming Ying Gan Shu Ting Tammie Seethor Christoph Paul Vincent Hornik Bobby Tan Jan Hau Lee Rachel G Greenberg |
| author_facet | Jen Heng Pek Shu-Ling Chong Bei Jun Yap Ming Ying Gan Shu Ting Tammie Seethor Christoph Paul Vincent Hornik Bobby Tan Jan Hau Lee Rachel G Greenberg |
| author_sort | Jen Heng Pek |
| collection | DOAJ |
| description | Introduction Neonatal sepsis has a high mortality rate that varies across different populations. We aim to perform a contemporary global evidence synthesis to determine the case fatality rates of neonatal sepsis, in order to better delineate this public health urgency and inform strategies to reduce fatality in this high-risk population.Methods and analysis We will search PubMed, Cochrane Central, Embase and Web of Science for articles in English language published between January 2010 and December 2019. All clinical trials and observational studies involving infants less than 90 days old with a clinical diagnosis of sepsis and reported case fatality rate will be included. Two independent reviewers will screen the studies and extract data on study variables chosen a priori. Quality of evidence and risk of bias will be assessed using Cochrane Collaboration’s tool and ROBINS-I. Results will be synthesised qualitatively and pooled for meta-analysis.Ethics and dissemination No formal ethical approval is required as there is no collection of primary data. This systematic review and meta-analysis will be disseminated through conference meetings and peer-reviewed publications.PROSPERO registration number CRD42020164321. |
| format | Article |
| id | doaj-art-cd768ea4f6da4fb59d94446ed714d760 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-cd768ea4f6da4fb59d94446ed714d7602025-08-20T02:36:02ZengBMJ Publishing GroupBMJ Open2044-60552020-07-0110710.1136/bmjopen-2020-038815Contemporary trends in global mortality of sepsis among young infants less than 90 days old: protocol for a systematic review and meta-analysisJen Heng Pek0Shu-Ling Chong1Bei Jun Yap2Ming Ying Gan3Shu Ting Tammie Seethor4Christoph Paul Vincent Hornik5Bobby Tan6Jan Hau Lee7Rachel G Greenberg8Emergency Medicine, Sengkang General Hospital, SingaporeDepartment of Children’s Emergency, KK Women’s and Children’s Hospital, Singapore, SingaporeYong Loo Lin School of Medicine, National University of Singapore, SingaporeYong Loo Lin School of Medicine, National University of Singapore, SingaporeYong Loo Lin School of Medicine, National University of Singapore, SingaporeDivision of Critical Care Medicine, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USADepartment of Paediatrics, KK Women`s and Children`s Hospital, SingaporeChildren’s Intensive Care Unit, KK Women’s and Children’s Hospital, Singapore3 Pediatrics, Neonatology, Duke University, Durham, North Carolina, USAIntroduction Neonatal sepsis has a high mortality rate that varies across different populations. We aim to perform a contemporary global evidence synthesis to determine the case fatality rates of neonatal sepsis, in order to better delineate this public health urgency and inform strategies to reduce fatality in this high-risk population.Methods and analysis We will search PubMed, Cochrane Central, Embase and Web of Science for articles in English language published between January 2010 and December 2019. All clinical trials and observational studies involving infants less than 90 days old with a clinical diagnosis of sepsis and reported case fatality rate will be included. Two independent reviewers will screen the studies and extract data on study variables chosen a priori. Quality of evidence and risk of bias will be assessed using Cochrane Collaboration’s tool and ROBINS-I. Results will be synthesised qualitatively and pooled for meta-analysis.Ethics and dissemination No formal ethical approval is required as there is no collection of primary data. This systematic review and meta-analysis will be disseminated through conference meetings and peer-reviewed publications.PROSPERO registration number CRD42020164321.https://bmjopen.bmj.com/content/10/7/e038815.full |
| spellingShingle | Jen Heng Pek Shu-Ling Chong Bei Jun Yap Ming Ying Gan Shu Ting Tammie Seethor Christoph Paul Vincent Hornik Bobby Tan Jan Hau Lee Rachel G Greenberg Contemporary trends in global mortality of sepsis among young infants less than 90 days old: protocol for a systematic review and meta-analysis BMJ Open |
| title | Contemporary trends in global mortality of sepsis among young infants less than 90 days old: protocol for a systematic review and meta-analysis |
| title_full | Contemporary trends in global mortality of sepsis among young infants less than 90 days old: protocol for a systematic review and meta-analysis |
| title_fullStr | Contemporary trends in global mortality of sepsis among young infants less than 90 days old: protocol for a systematic review and meta-analysis |
| title_full_unstemmed | Contemporary trends in global mortality of sepsis among young infants less than 90 days old: protocol for a systematic review and meta-analysis |
| title_short | Contemporary trends in global mortality of sepsis among young infants less than 90 days old: protocol for a systematic review and meta-analysis |
| title_sort | contemporary trends in global mortality of sepsis among young infants less than 90 days old protocol for a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/10/7/e038815.full |
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