Reference values of lymphocyte subsets from healthy Polish adults
The flow cytometry method could support physicians’ decisions in the diagnosis and treatment monitoring of immunodeficient patients. Most clinical recommendations are focused on the search for alterations in T- and B-lymphocyte subsets, less commonly natural killer (NK) cells and granulocytes. While...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2024-03-01
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| Series: | Central European Journal of Immunology |
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| Online Access: | https://www.termedia.pl/Reference-values-of-lymphocyte-subsets-from-healthy-Polish-adults,10,52655,1,1.html |
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| author | Aleksander Roszczyk Michał Zych Dariusz Sołdacki Radoslaw Zagozdzon Monika J. Kniotek |
| author_facet | Aleksander Roszczyk Michał Zych Dariusz Sołdacki Radoslaw Zagozdzon Monika J. Kniotek |
| author_sort | Aleksander Roszczyk |
| collection | DOAJ |
| description | The flow cytometry method could support physicians’ decisions in the diagnosis and treatment monitoring of immunodeficient patients. Most clinical recommendations are focused on the search for alterations in T- and B-lymphocyte subsets, less commonly natural killer (NK) cells and granulocytes. While reference values for clinically meaningful lymphocyte subsets have been published ubiquitously among numerous countries, we have not found significant data for a population of adult Polish habitats; thus we determined reference values for T, B, and NK subsets according to sex and age. The female group showed a higher percentage of lymphocytes (CD45 ++ ), T helper lymphocytes with a higher absolute count, as well as CD4/CD8 ratio, marginal zone-like B cells, class-switched B cells, and CD21 low B cells than the male group. The male group was found to have elevated percentages of naïve B lymphocytes, transitional B cells, and plasmablasts. A weak positive correlation with age was found among double positive T lymphocytes, natural killer T cells (NKT) lymphocytes, and CD21 low B cells. A negative correlation with age for double negative T lymphocytes, marginal zone-like B cells, and plasmablasts was noted. The results indicated the importance of creating distinct reference ranges regarding sex and age concerning immunophenotype. |
| format | Article |
| id | doaj-art-cd74b91efc7245b69dcfb15bbd2976bd |
| institution | OA Journals |
| issn | 1426-3912 1644-4124 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Central European Journal of Immunology |
| spelling | doaj-art-cd74b91efc7245b69dcfb15bbd2976bd2025-08-20T02:09:38ZengTermedia Publishing HouseCentral European Journal of Immunology1426-39121644-41242024-03-01491263610.5114/ceji.2024.13637152655Reference values of lymphocyte subsets from healthy Polish adultsAleksander RoszczykMichał ZychDariusz SołdackiRadoslaw ZagozdzonMonika J. KniotekThe flow cytometry method could support physicians’ decisions in the diagnosis and treatment monitoring of immunodeficient patients. Most clinical recommendations are focused on the search for alterations in T- and B-lymphocyte subsets, less commonly natural killer (NK) cells and granulocytes. While reference values for clinically meaningful lymphocyte subsets have been published ubiquitously among numerous countries, we have not found significant data for a population of adult Polish habitats; thus we determined reference values for T, B, and NK subsets according to sex and age. The female group showed a higher percentage of lymphocytes (CD45 ++ ), T helper lymphocytes with a higher absolute count, as well as CD4/CD8 ratio, marginal zone-like B cells, class-switched B cells, and CD21 low B cells than the male group. The male group was found to have elevated percentages of naïve B lymphocytes, transitional B cells, and plasmablasts. A weak positive correlation with age was found among double positive T lymphocytes, natural killer T cells (NKT) lymphocytes, and CD21 low B cells. A negative correlation with age for double negative T lymphocytes, marginal zone-like B cells, and plasmablasts was noted. The results indicated the importance of creating distinct reference ranges regarding sex and age concerning immunophenotype.https://www.termedia.pl/Reference-values-of-lymphocyte-subsets-from-healthy-Polish-adults,10,52655,1,1.htmlb lymphocytes subsets class-switching b lymphocytes cvid – common variable immunodeficiency flow cytometry healthy adults immunophenotype lymphocyte subsets peripheral blood nk – natural killer nkt – natural killer t cells primary immunodeficiency – pid reference values |
| spellingShingle | Aleksander Roszczyk Michał Zych Dariusz Sołdacki Radoslaw Zagozdzon Monika J. Kniotek Reference values of lymphocyte subsets from healthy Polish adults Central European Journal of Immunology b lymphocytes subsets class-switching b lymphocytes cvid – common variable immunodeficiency flow cytometry healthy adults immunophenotype lymphocyte subsets peripheral blood nk – natural killer nkt – natural killer t cells primary immunodeficiency – pid reference values |
| title | Reference values of lymphocyte subsets from healthy Polish adults |
| title_full | Reference values of lymphocyte subsets from healthy Polish adults |
| title_fullStr | Reference values of lymphocyte subsets from healthy Polish adults |
| title_full_unstemmed | Reference values of lymphocyte subsets from healthy Polish adults |
| title_short | Reference values of lymphocyte subsets from healthy Polish adults |
| title_sort | reference values of lymphocyte subsets from healthy polish adults |
| topic | b lymphocytes subsets class-switching b lymphocytes cvid – common variable immunodeficiency flow cytometry healthy adults immunophenotype lymphocyte subsets peripheral blood nk – natural killer nkt – natural killer t cells primary immunodeficiency – pid reference values |
| url | https://www.termedia.pl/Reference-values-of-lymphocyte-subsets-from-healthy-Polish-adults,10,52655,1,1.html |
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