Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials.
<h4>Objective</h4>To assess the efficacy of probiotic Lactobacillus on serum lipids using a meta-analysis of randomized, controlled trials.<h4>Methods</h4>Fifteen studies containing 15 trials, with 976 subjects were included. The pooled WMD was calculated by random effects mo...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0178868 |
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| author | Yucheng Wu Qingqing Zhang Yin Ren Zhongbao Ruan |
| author_facet | Yucheng Wu Qingqing Zhang Yin Ren Zhongbao Ruan |
| author_sort | Yucheng Wu |
| collection | DOAJ |
| description | <h4>Objective</h4>To assess the efficacy of probiotic Lactobacillus on serum lipids using a meta-analysis of randomized, controlled trials.<h4>Methods</h4>Fifteen studies containing 15 trials, with 976 subjects were included. The pooled WMD was calculated by random effects model.<h4>Results</h4>Probiotic Lactobacillus consumption significantly reduced TC by 0.26mmol/l (95% CI, -0.40 to -0.12) and LDL-C by 0.23mmol/l (95% CI, -0.36 to -0.10). Subgroup analysis of trials found significantly reduction of TC using L. plantarum and reduction of LDL-C using L. plantarum or L. reuteri. No significant effects were found on TG and HDL-C levels after supplementation with probiotic Lactobacillus. While, subgroup analysis found significantly beneficial effects on TG and HDL-C by consuming synbiotic food, containing L. sporogenes and inulin.<h4>Conclusion</h4>Consuming probiotic Lactobacillus, especially L. reuteri and L. plantarm, could reduce TC and LDL-C significantly. The study also suggested significantly beneficial effects on TG and HDL-C by consuming synbiotic food, containing L. sporogenes and inulin. |
| format | Article |
| id | doaj-art-cd730cede6664330b9693cb2d9a642f3 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-cd730cede6664330b9693cb2d9a642f32025-08-20T03:26:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01126e017886810.1371/journal.pone.0178868Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials.Yucheng WuQingqing ZhangYin RenZhongbao Ruan<h4>Objective</h4>To assess the efficacy of probiotic Lactobacillus on serum lipids using a meta-analysis of randomized, controlled trials.<h4>Methods</h4>Fifteen studies containing 15 trials, with 976 subjects were included. The pooled WMD was calculated by random effects model.<h4>Results</h4>Probiotic Lactobacillus consumption significantly reduced TC by 0.26mmol/l (95% CI, -0.40 to -0.12) and LDL-C by 0.23mmol/l (95% CI, -0.36 to -0.10). Subgroup analysis of trials found significantly reduction of TC using L. plantarum and reduction of LDL-C using L. plantarum or L. reuteri. No significant effects were found on TG and HDL-C levels after supplementation with probiotic Lactobacillus. While, subgroup analysis found significantly beneficial effects on TG and HDL-C by consuming synbiotic food, containing L. sporogenes and inulin.<h4>Conclusion</h4>Consuming probiotic Lactobacillus, especially L. reuteri and L. plantarm, could reduce TC and LDL-C significantly. The study also suggested significantly beneficial effects on TG and HDL-C by consuming synbiotic food, containing L. sporogenes and inulin.https://doi.org/10.1371/journal.pone.0178868 |
| spellingShingle | Yucheng Wu Qingqing Zhang Yin Ren Zhongbao Ruan Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials. PLoS ONE |
| title | Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials. |
| title_full | Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials. |
| title_fullStr | Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials. |
| title_full_unstemmed | Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials. |
| title_short | Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials. |
| title_sort | effect of probiotic lactobacillus on lipid profile a systematic review and meta analysis of randomized controlled trials |
| url | https://doi.org/10.1371/journal.pone.0178868 |
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