Post-discharge major bleeding/all-cause death in acute coronary syndrome: academic research consortium criteria versus Japan-specific criteria
Abstract Background The differentiation of the Academic Research Consortium high bleeding risk (HBR) (ARC-HBR) criteria and those modified for Japanese patients (J-HBR) for predicting events following discharge in patients with acute coronary syndrome (ACS) has yet to be clarified. In this study, we...
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BMC
2025-05-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04834-1 |
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| author | Hironori Ishiguchi Yu Yasuda Hiroya Mabuchi Madoka Yamaguchi Kei Murakami Natsu Kinoshita Takayoshi Kato Masaaki Yoshida Kazuhiko Sonoyama Koji Imoto Takayuki Okamura Akihiro Endo Shigeki Kobayashi Kazuaki Tanabe Motoaki Sano Tsuyoshi Oda |
| author_facet | Hironori Ishiguchi Yu Yasuda Hiroya Mabuchi Madoka Yamaguchi Kei Murakami Natsu Kinoshita Takayoshi Kato Masaaki Yoshida Kazuhiko Sonoyama Koji Imoto Takayuki Okamura Akihiro Endo Shigeki Kobayashi Kazuaki Tanabe Motoaki Sano Tsuyoshi Oda |
| author_sort | Hironori Ishiguchi |
| collection | DOAJ |
| description | Abstract Background The differentiation of the Academic Research Consortium high bleeding risk (HBR) (ARC-HBR) criteria and those modified for Japanese patients (J-HBR) for predicting events following discharge in patients with acute coronary syndrome (ACS) has yet to be clarified. In this study, we compared the ARC-HBR and J-HBR criteria for predicting post-discharge bleeding and associated events in patients with ACS. Methods We retrospectively analyzed data from 889 patients with ACS discharged alive at two tertiary hospitals in Japan between August 2009 and July 2018. We identified patients with HBR using both sets of criteria. We compared the incidence of major bleeding/all-cause death within 2 years following discharge and performance metrics between each set of criteria, and explored the efficacy of combining both sets of criteria to stratify risk levels for the prediction of clinical events. Results Eighty patients experienced major bleeding/all-cause death. In the ARC-HBR and J-HBR criteria, 51% and 65% of patients were categorized as HBR, respectively. Both sets of criteria effectively identified patients at a high risk of major bleeding/all-cause death. The ARC-HBR demonstrated a significantly higher area under the curve (AUC) for major bleeding and all-cause death combined (AUC [95% confidence interval]: 0.67 [0.64–0.69]) than that of the J-HBR (0.63 [0.60–0.66], P = 0.015). In each component, while the AUC for major bleeding was comparable between the two sets of criteria (0.61 [0.57–0.64] vs. 0.61 [0.57–0.63], P = 0.95), the ARC-HBR criteria showed a significantly higher AUC for all-cause death than the J-HBR criteria (0.67 [0.64–0.70] vs. 0.61 [0.59–0.64], P < 0.001). The combined use of both sets of criteria effectively stratified the risk for major bleeding/all-cause death (hazard ratio [95% confident interval]: 5.81 [2.79–12.07] in those positive for both sets of criteria, compared to those negative in both sets of criteria). Conclusions The ARC-HBR criteria demonstrated a greater discriminative capability for predicting major bleeding/all-cause mortality than the J-HBR criteria. For major bleeding alone, the discriminative ability of both sets of criteria was comparable. Graphical Abstract ACS, acute coronary syndrome; ARC-HBR, Academic Research Consortium-High Bleeding Risk; AUC, area under the curve; CI, confidence interval; HR, hazard ratio; J-HBR, Japanese-High Bleeding Risk. *: statistical significance. §: patients with the ARC-HBR criteria but without the J-HBR unique components. |
| format | Article |
| id | doaj-art-cd7244db3f00424da47e2f3faf33649e |
| institution | OA Journals |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-cd7244db3f00424da47e2f3faf33649e2025-08-20T01:52:03ZengBMCBMC Cardiovascular Disorders1471-22612025-05-0125111110.1186/s12872-025-04834-1Post-discharge major bleeding/all-cause death in acute coronary syndrome: academic research consortium criteria versus Japan-specific criteriaHironori Ishiguchi0Yu Yasuda1Hiroya Mabuchi2Madoka Yamaguchi3Kei Murakami4Natsu Kinoshita5Takayoshi Kato6Masaaki Yoshida7Kazuhiko Sonoyama8Koji Imoto9Takayuki Okamura10Akihiro Endo11Shigeki Kobayashi12Kazuaki Tanabe13Motoaki Sano14Tsuyoshi Oda15Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of MedicineDepartment of Cardiology, National Hospital Organisation Hamada Medical CenterGeneral Medicine, Iinan HospitalDivision of Cardiology, Faculty of Medicine, Shimane UniversityDivision of Cardiology, Shimane Prefectural Central HospitalDivision of Cardiology, Shimane Prefectural Central HospitalDivision of Cardiology, Shimane Prefectural Central HospitalDivision of Cardiology, Shimane Prefectural Central HospitalDivision of Cardiology, Shimane Prefectural Central HospitalDivision of Cardiology, Shimane Prefectural Central HospitalDepartment of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of MedicineDivision of Cardiology, Faculty of Medicine, Shimane UniversityDepartment of Therapeutic Science for Heart Failure in the Elderly, Yamaguchi University School of MedicineDivision of Cardiology, Faculty of Medicine, Shimane UniversityDepartment of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of MedicineDivision of Cardiology, Shimane Prefectural Central HospitalAbstract Background The differentiation of the Academic Research Consortium high bleeding risk (HBR) (ARC-HBR) criteria and those modified for Japanese patients (J-HBR) for predicting events following discharge in patients with acute coronary syndrome (ACS) has yet to be clarified. In this study, we compared the ARC-HBR and J-HBR criteria for predicting post-discharge bleeding and associated events in patients with ACS. Methods We retrospectively analyzed data from 889 patients with ACS discharged alive at two tertiary hospitals in Japan between August 2009 and July 2018. We identified patients with HBR using both sets of criteria. We compared the incidence of major bleeding/all-cause death within 2 years following discharge and performance metrics between each set of criteria, and explored the efficacy of combining both sets of criteria to stratify risk levels for the prediction of clinical events. Results Eighty patients experienced major bleeding/all-cause death. In the ARC-HBR and J-HBR criteria, 51% and 65% of patients were categorized as HBR, respectively. Both sets of criteria effectively identified patients at a high risk of major bleeding/all-cause death. The ARC-HBR demonstrated a significantly higher area under the curve (AUC) for major bleeding and all-cause death combined (AUC [95% confidence interval]: 0.67 [0.64–0.69]) than that of the J-HBR (0.63 [0.60–0.66], P = 0.015). In each component, while the AUC for major bleeding was comparable between the two sets of criteria (0.61 [0.57–0.64] vs. 0.61 [0.57–0.63], P = 0.95), the ARC-HBR criteria showed a significantly higher AUC for all-cause death than the J-HBR criteria (0.67 [0.64–0.70] vs. 0.61 [0.59–0.64], P < 0.001). The combined use of both sets of criteria effectively stratified the risk for major bleeding/all-cause death (hazard ratio [95% confident interval]: 5.81 [2.79–12.07] in those positive for both sets of criteria, compared to those negative in both sets of criteria). Conclusions The ARC-HBR criteria demonstrated a greater discriminative capability for predicting major bleeding/all-cause mortality than the J-HBR criteria. For major bleeding alone, the discriminative ability of both sets of criteria was comparable. Graphical Abstract ACS, acute coronary syndrome; ARC-HBR, Academic Research Consortium-High Bleeding Risk; AUC, area under the curve; CI, confidence interval; HR, hazard ratio; J-HBR, Japanese-High Bleeding Risk. *: statistical significance. §: patients with the ARC-HBR criteria but without the J-HBR unique components.https://doi.org/10.1186/s12872-025-04834-1ARC-HBRHigh bleeding riskAcute myocardial infarction |
| spellingShingle | Hironori Ishiguchi Yu Yasuda Hiroya Mabuchi Madoka Yamaguchi Kei Murakami Natsu Kinoshita Takayoshi Kato Masaaki Yoshida Kazuhiko Sonoyama Koji Imoto Takayuki Okamura Akihiro Endo Shigeki Kobayashi Kazuaki Tanabe Motoaki Sano Tsuyoshi Oda Post-discharge major bleeding/all-cause death in acute coronary syndrome: academic research consortium criteria versus Japan-specific criteria BMC Cardiovascular Disorders ARC-HBR High bleeding risk Acute myocardial infarction |
| title | Post-discharge major bleeding/all-cause death in acute coronary syndrome: academic research consortium criteria versus Japan-specific criteria |
| title_full | Post-discharge major bleeding/all-cause death in acute coronary syndrome: academic research consortium criteria versus Japan-specific criteria |
| title_fullStr | Post-discharge major bleeding/all-cause death in acute coronary syndrome: academic research consortium criteria versus Japan-specific criteria |
| title_full_unstemmed | Post-discharge major bleeding/all-cause death in acute coronary syndrome: academic research consortium criteria versus Japan-specific criteria |
| title_short | Post-discharge major bleeding/all-cause death in acute coronary syndrome: academic research consortium criteria versus Japan-specific criteria |
| title_sort | post discharge major bleeding all cause death in acute coronary syndrome academic research consortium criteria versus japan specific criteria |
| topic | ARC-HBR High bleeding risk Acute myocardial infarction |
| url | https://doi.org/10.1186/s12872-025-04834-1 |
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