Inflammatory genital infections mitigate a severe genetic bottleneck in heterosexual transmission of subtype A and C HIV-1.

Inflammatory genital infections mitigate a severe genetic bottleneck in heterosexual transmission of subtype A and C HIV-1.

The HIV-1 epidemic in sub-Saharan Africa is driven largely by heterosexual transmission of non-subtype B viruses, of which subtypes C and A are predominant. Previous studies of subtype B and subtype C transmission pairs have suggested that a single variant from the chronically infected partner can e...

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Bibliographic Details
Main Authors: Richard E Haaland, Paulina A Hawkins, Jesus Salazar-Gonzalez, Amber Johnson, Amanda Tichacek, Etienne Karita, Olivier Manigart, Joseph Mulenga, Brandon F Keele, George M Shaw, Beatrice H Hahn, Susan A Allen, Cynthia A Derdeyn, Eric Hunter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000274&type=printable
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