Association between exposure to 35 environmental pollutants and mortality from cerebrovascular diseases: A long-term prospective study
Environmental pollutants have been implicated in various detrimental health effects. However, the specific relationship between environmental pollutant exposure and the risk of cerebrovascular disease mortality remains uncertain. This study aimed to comprehensively explore the potential relationship...
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Elsevier
2025-02-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325001381 |
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| author | Lingjun Yan Bingqin Xie Zilin Liu Yu Huang Chenyu Ding Wenhua Fang Fuxin Lin Yuanxiang Lin Dezhi Kang Fa Chen |
| author_facet | Lingjun Yan Bingqin Xie Zilin Liu Yu Huang Chenyu Ding Wenhua Fang Fuxin Lin Yuanxiang Lin Dezhi Kang Fa Chen |
| author_sort | Lingjun Yan |
| collection | DOAJ |
| description | Environmental pollutants have been implicated in various detrimental health effects. However, the specific relationship between environmental pollutant exposure and the risk of cerebrovascular disease mortality remains uncertain. This study aimed to comprehensively explore the potential relationship between environmental pollutant exposure and risk of cerebrovascular disease mortality in the U.S. population. Data on 35 types of environmental pollutant exposure were extracted from the National Health and Nutrition Examination Survey (NHANES). Cerebrovascular disease-related deaths were ascertained from the National Center for Health Statistics, with mortality follow-up data available until December 31, 2019. Weighted univariable and multivariable Cox regression analyses were employed to evaluate the association between environmental pollutants and mortality from cerebrovascular diseases. A total of 11,643 participants were included for organochlorine pesticides, 11,912 for brominated flame retardants, 13,797 for per- and polyfluoroalkyl substances, and 14,560 for phthalates, with a median follow-up of 8.6 years. The average age of participants was approximately 46 years, with male participants comprising around 48 % of the cohort. Four types of organochlorine pesticides (hexachlorobenzene, oxychlordane, 2,2-Bis(4-chlorophenyl)-1,1-dichloroethene, and trans-nonachlor), perfluorooctanoic acid, and mono-n-butyl phthalate were found to be associated with an increased risk of cerebrovascular disease mortality. Furthermore, the composite environmental index derived from these six pollutants also demonstrated a significant correlation with elevated cerebrovascular disease mortality risk. This prospective study provides evidence of an association between certain environmental pollutant exposure (especially for organochlorine pesticides) and risk of cerebrovascular disease mortality. These findings provide new insights into potential prevention strategies for this disease mortality from the perspective of environmental pollutant exposure. |
| format | Article |
| id | doaj-art-cd6be92c2de84d219cd9edba7263c979 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-cd6be92c2de84d219cd9edba7263c9792025-01-31T05:10:00ZengElsevierEcotoxicology and Environmental Safety0147-65132025-02-01291117802Association between exposure to 35 environmental pollutants and mortality from cerebrovascular diseases: A long-term prospective studyLingjun Yan0Bingqin Xie1Zilin Liu2Yu Huang3Chenyu Ding4Wenhua Fang5Fuxin Lin6Yuanxiang Lin7Dezhi Kang8Fa Chen9Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China; Fujian Provincial Institutes of Brain Disorders and Brain Sciences, First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China; Department of Neurosurgery, Binhai Branch of National Regional Medical Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350209, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, ChinaDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China; Department of Neurosurgery, Binhai Branch of National Regional Medical Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350209, ChinaDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China; Department of Neurosurgery, Binhai Branch of National Regional Medical Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350209, ChinaDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China; Department of Neurosurgery, Binhai Branch of National Regional Medical Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350209, ChinaDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China; Fujian Provincial Institutes of Brain Disorders and Brain Sciences, First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China; Department of Neurosurgery, Binhai Branch of National Regional Medical Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350209, ChinaDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China; Fujian Provincial Institutes of Brain Disorders and Brain Sciences, First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China; Department of Neurosurgery, Binhai Branch of National Regional Medical Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350209, China; Correspondence to: The First Affiliated Hospital, Fujian Medical University, No. 22, Chazhong Road, Taijiang District, Fuzhou 350005, China.Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, China; Clinical Research Unit, The Second Affiliated Hospital, Fujian Medical University, Quanzhou 362000, China; Correspondence to: Department of Epidemiology and Health Statistic, School of Public Health, Fujian Medical University, No.1 Xueyuan Road, Fuzhou 350122, China.Environmental pollutants have been implicated in various detrimental health effects. However, the specific relationship between environmental pollutant exposure and the risk of cerebrovascular disease mortality remains uncertain. This study aimed to comprehensively explore the potential relationship between environmental pollutant exposure and risk of cerebrovascular disease mortality in the U.S. population. Data on 35 types of environmental pollutant exposure were extracted from the National Health and Nutrition Examination Survey (NHANES). Cerebrovascular disease-related deaths were ascertained from the National Center for Health Statistics, with mortality follow-up data available until December 31, 2019. Weighted univariable and multivariable Cox regression analyses were employed to evaluate the association between environmental pollutants and mortality from cerebrovascular diseases. A total of 11,643 participants were included for organochlorine pesticides, 11,912 for brominated flame retardants, 13,797 for per- and polyfluoroalkyl substances, and 14,560 for phthalates, with a median follow-up of 8.6 years. The average age of participants was approximately 46 years, with male participants comprising around 48 % of the cohort. Four types of organochlorine pesticides (hexachlorobenzene, oxychlordane, 2,2-Bis(4-chlorophenyl)-1,1-dichloroethene, and trans-nonachlor), perfluorooctanoic acid, and mono-n-butyl phthalate were found to be associated with an increased risk of cerebrovascular disease mortality. Furthermore, the composite environmental index derived from these six pollutants also demonstrated a significant correlation with elevated cerebrovascular disease mortality risk. This prospective study provides evidence of an association between certain environmental pollutant exposure (especially for organochlorine pesticides) and risk of cerebrovascular disease mortality. These findings provide new insights into potential prevention strategies for this disease mortality from the perspective of environmental pollutant exposure.http://www.sciencedirect.com/science/article/pii/S0147651325001381Cerebrovascular diseasesDeathOrganochlorine pesticidePerfluorooctanoic acidPhthalates |
| spellingShingle | Lingjun Yan Bingqin Xie Zilin Liu Yu Huang Chenyu Ding Wenhua Fang Fuxin Lin Yuanxiang Lin Dezhi Kang Fa Chen Association between exposure to 35 environmental pollutants and mortality from cerebrovascular diseases: A long-term prospective study Ecotoxicology and Environmental Safety Cerebrovascular diseases Death Organochlorine pesticide Perfluorooctanoic acid Phthalates |
| title | Association between exposure to 35 environmental pollutants and mortality from cerebrovascular diseases: A long-term prospective study |
| title_full | Association between exposure to 35 environmental pollutants and mortality from cerebrovascular diseases: A long-term prospective study |
| title_fullStr | Association between exposure to 35 environmental pollutants and mortality from cerebrovascular diseases: A long-term prospective study |
| title_full_unstemmed | Association between exposure to 35 environmental pollutants and mortality from cerebrovascular diseases: A long-term prospective study |
| title_short | Association between exposure to 35 environmental pollutants and mortality from cerebrovascular diseases: A long-term prospective study |
| title_sort | association between exposure to 35 environmental pollutants and mortality from cerebrovascular diseases a long term prospective study |
| topic | Cerebrovascular diseases Death Organochlorine pesticide Perfluorooctanoic acid Phthalates |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325001381 |
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