Small molecule-driven LKB1 deacetylation is responsible for the inhibition of hepatic lipid response in NAFLD

Small molecule-driven LKB1 deacetylation is responsible for the inhibition of hepatic lipid response in NAFLD

Nonalcoholic fatty liver disease (NAFLD) is a progressive condition characterized by ectopic fat accumulation in the liver, for which no FAD-approved drugs currently exist. Emerging evidence highlights the role of liver kinase B1 (LKB1), a key metabolic regulator, has been proposed in NAFLD, particu...

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Bibliographic Details
Main Authors: Weiwei Qin, Yu Ding, Wenhao Zhang, Lu Sun, Jianping Weng, Xueying Zheng, Sihui Luo
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Journal of Lipid Research
Subjects:
AMPK
Hepatic lipid response
HFHC
MCD
NASH
Tranilast
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227524002451
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