Apolipoprotein B/Apolipoprotein A1 ratio is an independent prognostic factor in pancreatic cancer
Objective: The relationship between serum lipids and prognosis of pancreatic cancer has not been confirmed. Our purpose in the study was to investigate the associations between serum lipids level and prognosis in patients with pancreatic cancer. Methods: A retrospective study was performed on 286 pa...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Translational Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523324003358 |
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| _version_ | 1850138344299692032 |
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| author | Chenxi Li Xuhui Yang Yan Zhong Wenying Wang Xin Jin Lihua Bian Xiaona Wang |
| author_facet | Chenxi Li Xuhui Yang Yan Zhong Wenying Wang Xin Jin Lihua Bian Xiaona Wang |
| author_sort | Chenxi Li |
| collection | DOAJ |
| description | Objective: The relationship between serum lipids and prognosis of pancreatic cancer has not been confirmed. Our purpose in the study was to investigate the associations between serum lipids level and prognosis in patients with pancreatic cancer. Methods: A retrospective study was performed on 286 pancreatic cancer patients who admitted to our hospital from January 1, 2017 to December 31, 2021. Serum lipids level were recorded. Clinical-pathological characteristics, oncologic outcomes, progression free survival (PFS) and overall survival (OS) were collected. The prognostic significance was determined by Kaplan-Meier analysis and Cox proportional hazards regression model. Results: Regarding serum lipids level, compared to normal apolipoprotein B/ apolipoprotein A (ApoB/ApoA1), high ApoB/ApoA1 level indicated a shorter OS (HR:2.028, 95% CI: 1.174–2.504, P = 0.011) and a shorter PFS (HR:1.800, 95% CI: 1.076–3.009, P = 0.025). Other serum lipid molecules were not associated with PFS and OS. Conclusion: ApoB/ApoA1 might be an independent prognostic factor of pancreatic cancer. |
| format | Article |
| id | doaj-art-cd61951562d1449c8ba83bd03af2b5d8 |
| institution | OA Journals |
| issn | 1936-5233 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj-art-cd61951562d1449c8ba83bd03af2b5d82025-08-20T02:30:35ZengElsevierTranslational Oncology1936-52332025-01-015110220810.1016/j.tranon.2024.102208Apolipoprotein B/Apolipoprotein A1 ratio is an independent prognostic factor in pancreatic cancerChenxi Li0Xuhui Yang1Yan Zhong2Wenying Wang3Xin Jin4Lihua Bian5Xiaona Wang6Senior Department of Oncology, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, PR ChinaSenior Department of Oncology, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, PR ChinaDepartment of Radiology, the Fourth Medical Center, Chinese PLA General Hospital, Beijing, PR ChinaSenior Department of Obstetrics & Gynecology, the Seventh Medical Center, Chinese PLA General Hospital, Beijing, PR ChinaSenior Department of Hepato- Pancreato- Biliary Surgery, the First Medical Center, Chinese PLA General Hospital, Beijing, PR ChinaDepartment of Obstetrics and Gynecology, Hainan Hospital of PLA General Hospital, Sanya, PR ChinaDepartment of Cardiology, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, PR China; Correspondence author at: Department of Cardiology, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, PR China.Objective: The relationship between serum lipids and prognosis of pancreatic cancer has not been confirmed. Our purpose in the study was to investigate the associations between serum lipids level and prognosis in patients with pancreatic cancer. Methods: A retrospective study was performed on 286 pancreatic cancer patients who admitted to our hospital from January 1, 2017 to December 31, 2021. Serum lipids level were recorded. Clinical-pathological characteristics, oncologic outcomes, progression free survival (PFS) and overall survival (OS) were collected. The prognostic significance was determined by Kaplan-Meier analysis and Cox proportional hazards regression model. Results: Regarding serum lipids level, compared to normal apolipoprotein B/ apolipoprotein A (ApoB/ApoA1), high ApoB/ApoA1 level indicated a shorter OS (HR:2.028, 95% CI: 1.174–2.504, P = 0.011) and a shorter PFS (HR:1.800, 95% CI: 1.076–3.009, P = 0.025). Other serum lipid molecules were not associated with PFS and OS. Conclusion: ApoB/ApoA1 might be an independent prognostic factor of pancreatic cancer.http://www.sciencedirect.com/science/article/pii/S1936523324003358ApoB/ApoA1 ratioPancreatic cancerPrognosisMarkeroverall survival |
| spellingShingle | Chenxi Li Xuhui Yang Yan Zhong Wenying Wang Xin Jin Lihua Bian Xiaona Wang Apolipoprotein B/Apolipoprotein A1 ratio is an independent prognostic factor in pancreatic cancer Translational Oncology ApoB/ApoA1 ratio Pancreatic cancer Prognosis Marker overall survival |
| title | Apolipoprotein B/Apolipoprotein A1 ratio is an independent prognostic factor in pancreatic cancer |
| title_full | Apolipoprotein B/Apolipoprotein A1 ratio is an independent prognostic factor in pancreatic cancer |
| title_fullStr | Apolipoprotein B/Apolipoprotein A1 ratio is an independent prognostic factor in pancreatic cancer |
| title_full_unstemmed | Apolipoprotein B/Apolipoprotein A1 ratio is an independent prognostic factor in pancreatic cancer |
| title_short | Apolipoprotein B/Apolipoprotein A1 ratio is an independent prognostic factor in pancreatic cancer |
| title_sort | apolipoprotein b apolipoprotein a1 ratio is an independent prognostic factor in pancreatic cancer |
| topic | ApoB/ApoA1 ratio Pancreatic cancer Prognosis Marker overall survival |
| url | http://www.sciencedirect.com/science/article/pii/S1936523324003358 |
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