Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics - Insights from a 3D Model of the Human Atria.
<h4>Aims</h4>Atrial stunning, a loss of atrial mechanical contraction, can occur following a successful cardioversion. It is hypothesized that persistent atrial fibrillation-induced electrical remodeling (AFER) on atrial electrophysiology may be responsible for such impaired atrial mecha...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0142397 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849331919319203840 |
|---|---|
| author | Ismail Adeniran David H MacIver Clifford J Garratt Jianqiao Ye Jules C Hancox Henggui Zhang |
| author_facet | Ismail Adeniran David H MacIver Clifford J Garratt Jianqiao Ye Jules C Hancox Henggui Zhang |
| author_sort | Ismail Adeniran |
| collection | DOAJ |
| description | <h4>Aims</h4>Atrial stunning, a loss of atrial mechanical contraction, can occur following a successful cardioversion. It is hypothesized that persistent atrial fibrillation-induced electrical remodeling (AFER) on atrial electrophysiology may be responsible for such impaired atrial mechanics. This simulation study aimed to investigate the effects of AFER on atrial electro-mechanics.<h4>Methods and results</h4>A 3D electromechanical model of the human atria was developed to investigate the effects of AFER on atrial electro-mechanics. Simulations were carried out in 3 conditions for 4 states: (i) the control condition, representing the normal tissue (state 1) and the tissue 2-3 months after cardioversion (state 2) when the atrial tissue recovers its electrophysiological properties after completion of reverse electrophysiological remodelling; (ii) AFER-SR condition for AF-remodeled tissue with normal sinus rhythm (SR) (state 3); and (iii) AFER-AF condition for AF-remodeled tissue with re-entrant excitation waves (state 4). Our results indicate that at the cellular level, AFER (states 3 & 4) abbreviated action potentials and reduced the Ca2+ content in the sarcoplasmic reticulum, resulting in a reduced amplitude of the intracellular Ca2+ transient leading to decreased cell active force and cell shortening as compared to the control condition (states 1 & 2). Consequently at the whole organ level, atrial contraction in AFER-SR condition (state 3) was dramatically reduced. In the AFER-AF condition (state 4) atrial contraction was almost abolished.<h4>Conclusions</h4>This study provides novel insights into understanding atrial electro-mechanics illustrating that AFER impairs atrial contraction due to reduced intracellular Ca2+ transients. |
| format | Article |
| id | doaj-art-cd5a9e9844ae41b3bfaf943e5088d29b |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-cd5a9e9844ae41b3bfaf943e5088d29b2025-08-20T03:46:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011011e014239710.1371/journal.pone.0142397Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics - Insights from a 3D Model of the Human Atria.Ismail AdeniranDavid H MacIverClifford J GarrattJianqiao YeJules C HancoxHenggui Zhang<h4>Aims</h4>Atrial stunning, a loss of atrial mechanical contraction, can occur following a successful cardioversion. It is hypothesized that persistent atrial fibrillation-induced electrical remodeling (AFER) on atrial electrophysiology may be responsible for such impaired atrial mechanics. This simulation study aimed to investigate the effects of AFER on atrial electro-mechanics.<h4>Methods and results</h4>A 3D electromechanical model of the human atria was developed to investigate the effects of AFER on atrial electro-mechanics. Simulations were carried out in 3 conditions for 4 states: (i) the control condition, representing the normal tissue (state 1) and the tissue 2-3 months after cardioversion (state 2) when the atrial tissue recovers its electrophysiological properties after completion of reverse electrophysiological remodelling; (ii) AFER-SR condition for AF-remodeled tissue with normal sinus rhythm (SR) (state 3); and (iii) AFER-AF condition for AF-remodeled tissue with re-entrant excitation waves (state 4). Our results indicate that at the cellular level, AFER (states 3 & 4) abbreviated action potentials and reduced the Ca2+ content in the sarcoplasmic reticulum, resulting in a reduced amplitude of the intracellular Ca2+ transient leading to decreased cell active force and cell shortening as compared to the control condition (states 1 & 2). Consequently at the whole organ level, atrial contraction in AFER-SR condition (state 3) was dramatically reduced. In the AFER-AF condition (state 4) atrial contraction was almost abolished.<h4>Conclusions</h4>This study provides novel insights into understanding atrial electro-mechanics illustrating that AFER impairs atrial contraction due to reduced intracellular Ca2+ transients.https://doi.org/10.1371/journal.pone.0142397 |
| spellingShingle | Ismail Adeniran David H MacIver Clifford J Garratt Jianqiao Ye Jules C Hancox Henggui Zhang Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics - Insights from a 3D Model of the Human Atria. PLoS ONE |
| title | Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics - Insights from a 3D Model of the Human Atria. |
| title_full | Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics - Insights from a 3D Model of the Human Atria. |
| title_fullStr | Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics - Insights from a 3D Model of the Human Atria. |
| title_full_unstemmed | Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics - Insights from a 3D Model of the Human Atria. |
| title_short | Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics - Insights from a 3D Model of the Human Atria. |
| title_sort | effects of persistent atrial fibrillation induced electrical remodeling on atrial electro mechanics insights from a 3d model of the human atria |
| url | https://doi.org/10.1371/journal.pone.0142397 |
| work_keys_str_mv | AT ismailadeniran effectsofpersistentatrialfibrillationinducedelectricalremodelingonatrialelectromechanicsinsightsfroma3dmodelofthehumanatria AT davidhmaciver effectsofpersistentatrialfibrillationinducedelectricalremodelingonatrialelectromechanicsinsightsfroma3dmodelofthehumanatria AT cliffordjgarratt effectsofpersistentatrialfibrillationinducedelectricalremodelingonatrialelectromechanicsinsightsfroma3dmodelofthehumanatria AT jianqiaoye effectsofpersistentatrialfibrillationinducedelectricalremodelingonatrialelectromechanicsinsightsfroma3dmodelofthehumanatria AT juleschancox effectsofpersistentatrialfibrillationinducedelectricalremodelingonatrialelectromechanicsinsightsfroma3dmodelofthehumanatria AT hengguizhang effectsofpersistentatrialfibrillationinducedelectricalremodelingonatrialelectromechanicsinsightsfroma3dmodelofthehumanatria |