PDGF-BB overexpressing dental pulp stem cells improve angiogenesis in dental pulp regeneration

PDGF-BB overexpressing dental pulp stem cells improve angiogenesis in dental pulp regeneration

IntroductionAngiogenesis represents a critical challenge in dental pulp regeneration due to the tissue’s restricted nutrient supply through a 0.5-mm apical foramen. While dental pulp stem cells (DPSCs) hold regenerative potential, their limited vascularization capacity impedes clinical applications....

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Bibliographic Details
Main Authors: Wentao Jiang, Shuhan Duan, Weiping Li, Huijiao Yan, Chenli Si, Ningwei Xu, Yishuai Li, Wenjie Zhang, Shensheng Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
dental pulp stem cells
vascularization
single-cell RNA sequencing
endothelial
dental pulp regeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1578410/full
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