Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats
Prebiotics may enhance iron absorption, and one plausible mechanism involves the production of short-chain fatty acids (SCFA) in the colon by intestinal microflora. The objectives of this study were to determine the effects of common commercially-available prebiotics including fructooligosaccharide...
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Tsinghua University Press
2021-05-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000331 |
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| author | Fan Zhang Ken K.L. Yung Chi KongYeung |
| author_facet | Fan Zhang Ken K.L. Yung Chi KongYeung |
| author_sort | Fan Zhang |
| collection | DOAJ |
| description | Prebiotics may enhance iron absorption, and one plausible mechanism involves the production of short-chain fatty acids (SCFA) in the colon by intestinal microflora. The objectives of this study were to determine the effects of common commercially-available prebiotics including fructooligosaccharide (FOS), inulin, FOS-inulin mixture, galactooligosaccharide (GOS), and lactulose on the iron status of anemic rats, and to monitor changes in the production of colonic SCFA. Anemic Sprague-Dawley rats receiving a low-iron diet (12 μg Fe/g diet) were supplemented with or without prebiotics (5% m/V in drinking water) for 5 weeks. Hemoglobin concentration in rats supplemented with GOS after 3 weeks (4.3 g/dL) was significantly higher than rats without supplementation (3.7 g/dL), while FOS also significantly increased hemoglobin concentration after 4 weeks (4.1 g/dL vs. 3.7 g/dL). All other prebiotics showed no effects. Anemic rats showed lower overall SCFA production in the colon than normal rats, and only FOS significantly increased the production of the three main SCFA (acetic acid, propionic acid and isobutyric acid) identified in anemic rats, with other prebiotics showing no noticeable trends. Our results suggest that GOS and FOS may slightly improve iron status of anemic rats, but the role of SCFA in the colon is not clear. |
| format | Article |
| id | doaj-art-cd5659a31a194293b481e12e0a0c4748 |
| institution | Kabale University |
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| language | English |
| publishDate | 2021-05-01 |
| publisher | Tsinghua University Press |
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| series | Food Science and Human Wellness |
| spelling | doaj-art-cd5659a31a194293b481e12e0a0c47482025-02-03T07:02:05ZengTsinghua University PressFood Science and Human Wellness2213-45302021-05-01103327334Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic ratsFan Zhang0Ken K.L. Yung1Chi KongYeung2Division of Science and Technology, BNU-HKBU United International College, Zhuhai, Guangdong, ChinaDepartment of Biology, Hong Kong Baptist University, Hong Kong, ChinaAnimal Science Department, California Polytechnic State University, San Luis Obispo, California, USA; Corresponding author. California Polytechnic State University, One Grand Ave. San Luis Obispo, CA 93407, USA.Prebiotics may enhance iron absorption, and one plausible mechanism involves the production of short-chain fatty acids (SCFA) in the colon by intestinal microflora. The objectives of this study were to determine the effects of common commercially-available prebiotics including fructooligosaccharide (FOS), inulin, FOS-inulin mixture, galactooligosaccharide (GOS), and lactulose on the iron status of anemic rats, and to monitor changes in the production of colonic SCFA. Anemic Sprague-Dawley rats receiving a low-iron diet (12 μg Fe/g diet) were supplemented with or without prebiotics (5% m/V in drinking water) for 5 weeks. Hemoglobin concentration in rats supplemented with GOS after 3 weeks (4.3 g/dL) was significantly higher than rats without supplementation (3.7 g/dL), while FOS also significantly increased hemoglobin concentration after 4 weeks (4.1 g/dL vs. 3.7 g/dL). All other prebiotics showed no effects. Anemic rats showed lower overall SCFA production in the colon than normal rats, and only FOS significantly increased the production of the three main SCFA (acetic acid, propionic acid and isobutyric acid) identified in anemic rats, with other prebiotics showing no noticeable trends. Our results suggest that GOS and FOS may slightly improve iron status of anemic rats, but the role of SCFA in the colon is not clear.http://www.sciencedirect.com/science/article/pii/S2213453021000331IronNon-digestible oligosaccharidesShort-chain fatty acidsPrebioticsRat |
| spellingShingle | Fan Zhang Ken K.L. Yung Chi KongYeung Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats Food Science and Human Wellness Iron Non-digestible oligosaccharides Short-chain fatty acids Prebiotics Rat |
| title | Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats |
| title_full | Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats |
| title_fullStr | Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats |
| title_full_unstemmed | Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats |
| title_short | Effects of common prebiotics on iron status and production of colonic short-chain fatty acids in anemic rats |
| title_sort | effects of common prebiotics on iron status and production of colonic short chain fatty acids in anemic rats |
| topic | Iron Non-digestible oligosaccharides Short-chain fatty acids Prebiotics Rat |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000331 |
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