Sperm imaging utilizing terahertz near-field scanning microscopy
Terahertz (THz)-based near-field imaging technology exhibits significant potential for applications in biomedical detection. This study investigates biological cells utilizing the rapid imaging capabilities, high resolution, and non-destructive characteristics inherent to terahertz scattering-based...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Biotechnology & Biotechnological Equipment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13102818.2025.2491500 |
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| author | Zhenchun Yu Chengyao Peng Shun Bai Yuanqi Zhao Yangyang Si Wenbing Zhang |
| author_facet | Zhenchun Yu Chengyao Peng Shun Bai Yuanqi Zhao Yangyang Si Wenbing Zhang |
| author_sort | Zhenchun Yu |
| collection | DOAJ |
| description | Terahertz (THz)-based near-field imaging technology exhibits significant potential for applications in biomedical detection. This study investigates biological cells utilizing the rapid imaging capabilities, high resolution, and non-destructive characteristics inherent to terahertz scattering-based scanning near-field optical microscopy (s-SNOM). The findings indicate that the integration of terahertz near-field microscopy with nanoprecision probes and a high-power terahertz radiation source transcends the size and resolution constraints of traditional terahertz far-field imaging systems, which typically achieve resolutions in the range of hundreds to tens of microns for smaller biological tissues. Furthermore, this approach addresses the intrinsic complexities associated with biological cells, such as the presence of numerous intracellular constituents and high water content, thereby facilitating clear and non-destructive imaging of both the surfaces and interiors of individual human sperm at resolutions on the order of tens of nanometers. The simultaneous acquisition of terahertz imaging data is accomplished in approximately 11 min, representing a substantial enhancement in imaging speed. This work not only serves as a compelling example but also presents an effective methodology for imaging medical biological samples using THz near-field microscopy. |
| format | Article |
| id | doaj-art-cd5586fe6046474db90f618230523d51 |
| institution | OA Journals |
| issn | 1310-2818 1314-3530 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Biotechnology & Biotechnological Equipment |
| spelling | doaj-art-cd5586fe6046474db90f618230523d512025-08-20T02:12:23ZengTaylor & Francis GroupBiotechnology & Biotechnological Equipment1310-28181314-35302025-12-0139110.1080/13102818.2025.2491500Sperm imaging utilizing terahertz near-field scanning microscopyZhenchun Yu0Chengyao Peng1Shun Bai2Yuanqi Zhao3Yangyang Si4Wenbing Zhang5Advanced Wave Source Research Center, Institute of Energy, Hefei Comprehensive National Science Center, Hefei, Anhui, ChinaAdvanced Wave Source Research Center, Institute of Energy, Hefei Comprehensive National Science Center, Hefei, Anhui, ChinaCenter for Reproduction and Genetics, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui, ChinaCenter for Reproduction and Genetics, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui, ChinaSchool of Physics and Electronic Information, Anhui Normal University, Wuhu, Anhui, ChinaAdvanced Wave Source Research Center, Institute of Energy, Hefei Comprehensive National Science Center, Hefei, Anhui, ChinaTerahertz (THz)-based near-field imaging technology exhibits significant potential for applications in biomedical detection. This study investigates biological cells utilizing the rapid imaging capabilities, high resolution, and non-destructive characteristics inherent to terahertz scattering-based scanning near-field optical microscopy (s-SNOM). The findings indicate that the integration of terahertz near-field microscopy with nanoprecision probes and a high-power terahertz radiation source transcends the size and resolution constraints of traditional terahertz far-field imaging systems, which typically achieve resolutions in the range of hundreds to tens of microns for smaller biological tissues. Furthermore, this approach addresses the intrinsic complexities associated with biological cells, such as the presence of numerous intracellular constituents and high water content, thereby facilitating clear and non-destructive imaging of both the surfaces and interiors of individual human sperm at resolutions on the order of tens of nanometers. The simultaneous acquisition of terahertz imaging data is accomplished in approximately 11 min, representing a substantial enhancement in imaging speed. This work not only serves as a compelling example but also presents an effective methodology for imaging medical biological samples using THz near-field microscopy.https://www.tandfonline.com/doi/10.1080/13102818.2025.2491500Terahertzspermnear-fieldimaging |
| spellingShingle | Zhenchun Yu Chengyao Peng Shun Bai Yuanqi Zhao Yangyang Si Wenbing Zhang Sperm imaging utilizing terahertz near-field scanning microscopy Biotechnology & Biotechnological Equipment Terahertz sperm near-field imaging |
| title | Sperm imaging utilizing terahertz near-field scanning microscopy |
| title_full | Sperm imaging utilizing terahertz near-field scanning microscopy |
| title_fullStr | Sperm imaging utilizing terahertz near-field scanning microscopy |
| title_full_unstemmed | Sperm imaging utilizing terahertz near-field scanning microscopy |
| title_short | Sperm imaging utilizing terahertz near-field scanning microscopy |
| title_sort | sperm imaging utilizing terahertz near field scanning microscopy |
| topic | Terahertz sperm near-field imaging |
| url | https://www.tandfonline.com/doi/10.1080/13102818.2025.2491500 |
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