The impact of preoperative stress on age-related cognitive dysfunction after abdominal surgery: a study using a rat model
Abstract Objective This study examines the impact of preoperative stress on postoperative neuroinflammation and associated cognitive dysfunction, with a focus on aged individuals. The goal is to determine whether managing preoperative stress can enhance postoperative outcomes and lower the risk of c...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | BMC Research Notes |
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| Online Access: | https://doi.org/10.1186/s13104-024-07023-z |
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| author | Natsuki Nakagoshi Fabricio M Locatelli Sonoe Kitamura Seiji Hirota Takashi Kawano |
| author_facet | Natsuki Nakagoshi Fabricio M Locatelli Sonoe Kitamura Seiji Hirota Takashi Kawano |
| author_sort | Natsuki Nakagoshi |
| collection | DOAJ |
| description | Abstract Objective This study examines the impact of preoperative stress on postoperative neuroinflammation and associated cognitive dysfunction, with a focus on aged individuals. The goal is to determine whether managing preoperative stress can enhance postoperative outcomes and lower the risk of cognitive impairment. Results In aged rats, preoperative restraint stress significantly worsened neuroinflammation and cognitive deficits following abdominal surgery. Elevated levels of pro-inflammatory cytokines were observed in the hippocampus and medial prefrontal cortex two days post-surgery, and these effects persisted for twenty-eight days. In contrast, adult rats did not show significant changes in neuroinflammation or cognitive function due to preoperative restraint stress. An ex vivo analysis indicated that hippocampal microglia from aged rats exhibited an intensified proinflammatory response to lipopolysaccharide stimulation, further heightened by preoperative restraint stress. These findings suggest that managing preoperative stress could mitigate these adverse effects, leading to better postoperative recovery and cognitive health in elderly patients. |
| format | Article |
| id | doaj-art-cd54d4e2acfe41079dfdc779963b8b53 |
| institution | OA Journals |
| issn | 1756-0500 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj-art-cd54d4e2acfe41079dfdc779963b8b532025-08-20T02:31:54ZengBMCBMC Research Notes1756-05002024-12-011711710.1186/s13104-024-07023-zThe impact of preoperative stress on age-related cognitive dysfunction after abdominal surgery: a study using a rat modelNatsuki Nakagoshi0Fabricio M Locatelli1Sonoe Kitamura2Seiji Hirota3Takashi Kawano4Department of Anesthesiology and Intensive Care Medicine, Kochi Medical SchoolDepartment of Anesthesiology and Intensive Care Medicine, Kochi Medical SchoolDepartment of Anesthesiology and Intensive Care Medicine, Kochi Medical SchoolDepartment of Anesthesiology and Intensive Care Medicine, Kochi Medical SchoolDepartment of Anesthesiology and Intensive Care Medicine, Kochi Medical SchoolAbstract Objective This study examines the impact of preoperative stress on postoperative neuroinflammation and associated cognitive dysfunction, with a focus on aged individuals. The goal is to determine whether managing preoperative stress can enhance postoperative outcomes and lower the risk of cognitive impairment. Results In aged rats, preoperative restraint stress significantly worsened neuroinflammation and cognitive deficits following abdominal surgery. Elevated levels of pro-inflammatory cytokines were observed in the hippocampus and medial prefrontal cortex two days post-surgery, and these effects persisted for twenty-eight days. In contrast, adult rats did not show significant changes in neuroinflammation or cognitive function due to preoperative restraint stress. An ex vivo analysis indicated that hippocampal microglia from aged rats exhibited an intensified proinflammatory response to lipopolysaccharide stimulation, further heightened by preoperative restraint stress. These findings suggest that managing preoperative stress could mitigate these adverse effects, leading to better postoperative recovery and cognitive health in elderly patients.https://doi.org/10.1186/s13104-024-07023-zPreoperative stressNeuroinflammationCognitive dysfunctionPostoperative deliriumAged rats |
| spellingShingle | Natsuki Nakagoshi Fabricio M Locatelli Sonoe Kitamura Seiji Hirota Takashi Kawano The impact of preoperative stress on age-related cognitive dysfunction after abdominal surgery: a study using a rat model BMC Research Notes Preoperative stress Neuroinflammation Cognitive dysfunction Postoperative delirium Aged rats |
| title | The impact of preoperative stress on age-related cognitive dysfunction after abdominal surgery: a study using a rat model |
| title_full | The impact of preoperative stress on age-related cognitive dysfunction after abdominal surgery: a study using a rat model |
| title_fullStr | The impact of preoperative stress on age-related cognitive dysfunction after abdominal surgery: a study using a rat model |
| title_full_unstemmed | The impact of preoperative stress on age-related cognitive dysfunction after abdominal surgery: a study using a rat model |
| title_short | The impact of preoperative stress on age-related cognitive dysfunction after abdominal surgery: a study using a rat model |
| title_sort | impact of preoperative stress on age related cognitive dysfunction after abdominal surgery a study using a rat model |
| topic | Preoperative stress Neuroinflammation Cognitive dysfunction Postoperative delirium Aged rats |
| url | https://doi.org/10.1186/s13104-024-07023-z |
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