Population pharmacokinetics of polymyxin B in critically ill patients with carbapenem-resistant organisms infections: insights from steady-state trough and peak plasma concentration

Population pharmacokinetics of polymyxin B in critically ill patients with carbapenem-resistant organisms infections: insights from steady-state trough and peak plasma concentration

AimsTo establish a population pharmacokinetic (PopPK) model of polymyxin B (PMB) in critically ill patients based on steady-state trough (Ctrough,ss) and peak (Cpeak,ss) concentrations, optimize the dosing regimen, and evaluate the consistency of 24-hour steady-state area under the concentration-tim...

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Bibliographic Details
Main Authors: Jun Yang, Mingjie Yu, Yu Gan, Lin Cheng, Ge Yang, Lirong Xiong, Fang Liu, Yongchuan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
population pharmacokinetics
polymyxin B
critical illness
dosing optimization
consistency
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1511088/full
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