Leukocytoclastic Vasculitis in a Patient with Type 1 Cryoglobulinemia
Cutaneous manifestations of type 1 cryoglobulinemia are usually related to vascular occlusion by noninflammatory thrombosis; rarely is leukocytoclastic vasculitis seen in type 1 cryoglobulinemia. We report the case of a 64-year-old male who presented with isolated cutaneous leukocytoclastic vasculit...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2011/124940 |
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| author | Paul Y. Liu Pamela E. Prete Gary Kukes |
| author_facet | Paul Y. Liu Pamela E. Prete Gary Kukes |
| author_sort | Paul Y. Liu |
| collection | DOAJ |
| description | Cutaneous manifestations of type 1 cryoglobulinemia are usually related to vascular occlusion by noninflammatory thrombosis; rarely is leukocytoclastic vasculitis seen in type 1 cryoglobulinemia. We report the case of a 64-year-old male who presented with isolated cutaneous leukocytoclastic vasculitis that was initially attributed to essential mixed cryoglobulinemia after thorough diagnostic evaluation. A lack of adequate clinical response to therapy prompted further investigation, including cryoprecipitate electrophoresis and immunofixation, which revealed an IgM kappa monoclonal gammopathy consistent with type 1 cryoglobulinemia. A renewed search for an underlying malignancy led to the discovery of early Waldenstrom's macroglobulinemia. Although leukocytoclastic vasculitis is more characteristic of mixed cryoglobulinemia, it can be a presenting manifestation of type 1 cryoglobulinemia. |
| format | Article |
| id | doaj-art-cd522a9e5e6e4e4fa8252a8b5214676b |
| institution | DOAJ |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-cd522a9e5e6e4e4fa8252a8b5214676b2025-08-20T03:19:35ZengWileyCase Reports in Rheumatology2090-68892090-68972011-01-01201110.1155/2011/124940124940Leukocytoclastic Vasculitis in a Patient with Type 1 CryoglobulinemiaPaul Y. Liu0Pamela E. Prete1Gary Kukes2Division of Rheumatology, Department of Medicine, University of California, Irvine, Orange, CA 92868, USADivision of Rheumatology, Department of Medicine, University of California, Irvine, Orange, CA 92868, USAVeterans Administration Healthcare System, Long Beach, CA 90822, USACutaneous manifestations of type 1 cryoglobulinemia are usually related to vascular occlusion by noninflammatory thrombosis; rarely is leukocytoclastic vasculitis seen in type 1 cryoglobulinemia. We report the case of a 64-year-old male who presented with isolated cutaneous leukocytoclastic vasculitis that was initially attributed to essential mixed cryoglobulinemia after thorough diagnostic evaluation. A lack of adequate clinical response to therapy prompted further investigation, including cryoprecipitate electrophoresis and immunofixation, which revealed an IgM kappa monoclonal gammopathy consistent with type 1 cryoglobulinemia. A renewed search for an underlying malignancy led to the discovery of early Waldenstrom's macroglobulinemia. Although leukocytoclastic vasculitis is more characteristic of mixed cryoglobulinemia, it can be a presenting manifestation of type 1 cryoglobulinemia.http://dx.doi.org/10.1155/2011/124940 |
| spellingShingle | Paul Y. Liu Pamela E. Prete Gary Kukes Leukocytoclastic Vasculitis in a Patient with Type 1 Cryoglobulinemia Case Reports in Rheumatology |
| title | Leukocytoclastic Vasculitis in a Patient with Type 1 Cryoglobulinemia |
| title_full | Leukocytoclastic Vasculitis in a Patient with Type 1 Cryoglobulinemia |
| title_fullStr | Leukocytoclastic Vasculitis in a Patient with Type 1 Cryoglobulinemia |
| title_full_unstemmed | Leukocytoclastic Vasculitis in a Patient with Type 1 Cryoglobulinemia |
| title_short | Leukocytoclastic Vasculitis in a Patient with Type 1 Cryoglobulinemia |
| title_sort | leukocytoclastic vasculitis in a patient with type 1 cryoglobulinemia |
| url | http://dx.doi.org/10.1155/2011/124940 |
| work_keys_str_mv | AT paulyliu leukocytoclasticvasculitisinapatientwithtype1cryoglobulinemia AT pamelaeprete leukocytoclasticvasculitisinapatientwithtype1cryoglobulinemia AT garykukes leukocytoclasticvasculitisinapatientwithtype1cryoglobulinemia |