Altered dynamic functional connectivity and reduced higher order information interaction in Parkinson’s patients with hyposmia
Abstract Hyposmia, a common non-motor symptom in Parkinson’s disease (PD) linked to reduced odor sensitivity, is associated with brain structural and functional changes, but dynamic brain activity and altered regional information exchange remain underexplored, limiting insight into underlying brain...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | npj Systems Biology and Applications |
| Online Access: | https://doi.org/10.1038/s41540-025-00574-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849331843798663168 |
|---|---|
| author | Sneha Ray Navkiran Kalsi Henning Boecker Neeraj Upadhyay Rajanikant Panda |
| author_facet | Sneha Ray Navkiran Kalsi Henning Boecker Neeraj Upadhyay Rajanikant Panda |
| author_sort | Sneha Ray |
| collection | DOAJ |
| description | Abstract Hyposmia, a common non-motor symptom in Parkinson’s disease (PD) linked to reduced odor sensitivity, is associated with brain structural and functional changes, but dynamic brain activity and altered regional information exchange remain underexplored, limiting insight into underlying brain states. We selected 15 PD patients with severe hyposmia (PD-SH), 15 PD patients with normal cognition (PD-CN), and 15 healthy controls (HC). Using functional MRI, we assessed the brain’s spatiotemporal connectivity (brain-state) alterations, and the brain’s capacity for higher-order information exchange (synergy and redundancy). A dynamic brain state with complex-long-range connections was significantly reduced in PD-SH and PD-CN, compared to HC. Brain-states consisting of modular-clusters in sensorimotor and frontal areas occurred more frequently in PD-SH than in PD-CN and HC. Higher-order information flow was reduced in PD patients, with PD-SH showing a greater reduction in synergetic information flow in frontal, insula, and left sensory-motor. These findings suggest potential discriminative biomarkers for PD-SH. |
| format | Article |
| id | doaj-art-cd4ddf01c6dd46a69d1e3892b9e53a40 |
| institution | Kabale University |
| issn | 2056-7189 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Systems Biology and Applications |
| spelling | doaj-art-cd4ddf01c6dd46a69d1e3892b9e53a402025-08-20T03:46:23ZengNature Portfolionpj Systems Biology and Applications2056-71892025-08-0111111210.1038/s41540-025-00574-2Altered dynamic functional connectivity and reduced higher order information interaction in Parkinson’s patients with hyposmiaSneha Ray0Navkiran Kalsi1Henning Boecker2Neeraj Upadhyay3Rajanikant Panda4Department of Neurosciences, Université de MonsJindal School of Psychology & Counselling, O P Jindal Global UniversityClinical Functional Imaging Lab, Department of Nuclear Medicine, University Hospital BonnClinical Functional Imaging Lab, Department of Nuclear Medicine, University Hospital BonnDepartment of Neurology, University of California, San FranciscoAbstract Hyposmia, a common non-motor symptom in Parkinson’s disease (PD) linked to reduced odor sensitivity, is associated with brain structural and functional changes, but dynamic brain activity and altered regional information exchange remain underexplored, limiting insight into underlying brain states. We selected 15 PD patients with severe hyposmia (PD-SH), 15 PD patients with normal cognition (PD-CN), and 15 healthy controls (HC). Using functional MRI, we assessed the brain’s spatiotemporal connectivity (brain-state) alterations, and the brain’s capacity for higher-order information exchange (synergy and redundancy). A dynamic brain state with complex-long-range connections was significantly reduced in PD-SH and PD-CN, compared to HC. Brain-states consisting of modular-clusters in sensorimotor and frontal areas occurred more frequently in PD-SH than in PD-CN and HC. Higher-order information flow was reduced in PD patients, with PD-SH showing a greater reduction in synergetic information flow in frontal, insula, and left sensory-motor. These findings suggest potential discriminative biomarkers for PD-SH.https://doi.org/10.1038/s41540-025-00574-2 |
| spellingShingle | Sneha Ray Navkiran Kalsi Henning Boecker Neeraj Upadhyay Rajanikant Panda Altered dynamic functional connectivity and reduced higher order information interaction in Parkinson’s patients with hyposmia npj Systems Biology and Applications |
| title | Altered dynamic functional connectivity and reduced higher order information interaction in Parkinson’s patients with hyposmia |
| title_full | Altered dynamic functional connectivity and reduced higher order information interaction in Parkinson’s patients with hyposmia |
| title_fullStr | Altered dynamic functional connectivity and reduced higher order information interaction in Parkinson’s patients with hyposmia |
| title_full_unstemmed | Altered dynamic functional connectivity and reduced higher order information interaction in Parkinson’s patients with hyposmia |
| title_short | Altered dynamic functional connectivity and reduced higher order information interaction in Parkinson’s patients with hyposmia |
| title_sort | altered dynamic functional connectivity and reduced higher order information interaction in parkinson s patients with hyposmia |
| url | https://doi.org/10.1038/s41540-025-00574-2 |
| work_keys_str_mv | AT sneharay altereddynamicfunctionalconnectivityandreducedhigherorderinformationinteractioninparkinsonspatientswithhyposmia AT navkirankalsi altereddynamicfunctionalconnectivityandreducedhigherorderinformationinteractioninparkinsonspatientswithhyposmia AT henningboecker altereddynamicfunctionalconnectivityandreducedhigherorderinformationinteractioninparkinsonspatientswithhyposmia AT neerajupadhyay altereddynamicfunctionalconnectivityandreducedhigherorderinformationinteractioninparkinsonspatientswithhyposmia AT rajanikantpanda altereddynamicfunctionalconnectivityandreducedhigherorderinformationinteractioninparkinsonspatientswithhyposmia |