Oxidative Stress and Nutritional Antioxidants in Renal Diseases: A Narrative Review
Oxidative stress is a key component in the pathogenesis of a broad number of renal disorders, including acute kidney injury, chronic kidney disease, and various types of nephropathies. Moreover, oxidative stress seems to at least partly explain the intricate relationship the kidney has with other pa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/7/757 |
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| author | Dorin Dragoș Iulia I. Enache Maria M. Manea |
| author_facet | Dorin Dragoș Iulia I. Enache Maria M. Manea |
| author_sort | Dorin Dragoș |
| collection | DOAJ |
| description | Oxidative stress is a key component in the pathogenesis of a broad number of renal disorders, including acute kidney injury, chronic kidney disease, and various types of nephropathies. Moreover, oxidative stress seems to at least partly explain the intricate relationship the kidney has with other pathological entities, for instance with cardiovascular comorbidities. Renal replacement therapies give end-stage renal disease patients a fighting chance; however, even these interventions may carry the risk of enhancing existing oxidative stress. Even if nutritional components are not currently routinely used, many have shown promise in preclinical or even clinical studies and could counter some of the deleterious pathways that oxidative stress sets in place. This narrative review provides an update on how these natural nutrients could be beneficial to renal disease patients, and it also aims to give an incentive to future research in the field. |
| format | Article |
| id | doaj-art-cd4cf8a4daa246d199f1b4b636527c9f |
| institution | DOAJ |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-cd4cf8a4daa246d199f1b4b636527c9f2025-08-20T02:45:48ZengMDPI AGAntioxidants2076-39212025-06-0114775710.3390/antiox14070757Oxidative Stress and Nutritional Antioxidants in Renal Diseases: A Narrative ReviewDorin Dragoș0Iulia I. Enache1Maria M. Manea2Faculty of Medicine, Department 1–Medical Semiology, Nephrology–Bucharest Emergency University Hospital, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDoctoral School, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, Department 6–Neurology–National Institute of Neurology and Neurovascular Diseases, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, RomaniaOxidative stress is a key component in the pathogenesis of a broad number of renal disorders, including acute kidney injury, chronic kidney disease, and various types of nephropathies. Moreover, oxidative stress seems to at least partly explain the intricate relationship the kidney has with other pathological entities, for instance with cardiovascular comorbidities. Renal replacement therapies give end-stage renal disease patients a fighting chance; however, even these interventions may carry the risk of enhancing existing oxidative stress. Even if nutritional components are not currently routinely used, many have shown promise in preclinical or even clinical studies and could counter some of the deleterious pathways that oxidative stress sets in place. This narrative review provides an update on how these natural nutrients could be beneficial to renal disease patients, and it also aims to give an incentive to future research in the field.https://www.mdpi.com/2076-3921/14/7/757acute kidney injurychronic kidney diseaseglomerulopathyaging kidneynephrolithiasisnatural nutrients |
| spellingShingle | Dorin Dragoș Iulia I. Enache Maria M. Manea Oxidative Stress and Nutritional Antioxidants in Renal Diseases: A Narrative Review Antioxidants acute kidney injury chronic kidney disease glomerulopathy aging kidney nephrolithiasis natural nutrients |
| title | Oxidative Stress and Nutritional Antioxidants in Renal Diseases: A Narrative Review |
| title_full | Oxidative Stress and Nutritional Antioxidants in Renal Diseases: A Narrative Review |
| title_fullStr | Oxidative Stress and Nutritional Antioxidants in Renal Diseases: A Narrative Review |
| title_full_unstemmed | Oxidative Stress and Nutritional Antioxidants in Renal Diseases: A Narrative Review |
| title_short | Oxidative Stress and Nutritional Antioxidants in Renal Diseases: A Narrative Review |
| title_sort | oxidative stress and nutritional antioxidants in renal diseases a narrative review |
| topic | acute kidney injury chronic kidney disease glomerulopathy aging kidney nephrolithiasis natural nutrients |
| url | https://www.mdpi.com/2076-3921/14/7/757 |
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