Secondary Neutropenias
Neutrophils are a critical component of immunity, particularly against bacteria and other pathogens, but also in inflammation and tissue repair. As a consequence, individuals with neutropenia, defined by a reduction in absolute neutrophil counts, exhibit a strong propensity to severe infections that...
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| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/2/497 |
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| _version_ | 1849719703344250880 |
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| author | Alister C. Ward |
| author_facet | Alister C. Ward |
| author_sort | Alister C. Ward |
| collection | DOAJ |
| description | Neutrophils are a critical component of immunity, particularly against bacteria and other pathogens, but also in inflammation and tissue repair. As a consequence, individuals with neutropenia, defined by a reduction in absolute neutrophil counts, exhibit a strong propensity to severe infections that typically present with muted symptoms. Neutropenias encompass a heterogeneous set of disorders, comprising primary neutropenias, in which specific genes are mutated, and the more common secondary neutropenias, which have diverse non-genetic causes. These include hematological and other cancers, involving both direct effects of the cancer itself and indirect impacts via the chemotherapeutic, biological agents and cell-based approaches used for treatment. Other significant causes of secondary neutropenias are non-chemotherapeutic drugs, autoimmune and other immune diseases, infections and nutrient deficiencies. These collectively act by impacting neutrophil production in the bone marrow and/or destruction throughout the body. This review describes the biological and clinical manifestations of secondary neutropenias, detailing their underlying causes and management, with a discussion of alternative and emerging therapeutic approaches. |
| format | Article |
| id | doaj-art-cd4ab3c9c4b14ad7b5c2d70ebd6bc612 |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-cd4ab3c9c4b14ad7b5c2d70ebd6bc6122025-08-20T03:12:05ZengMDPI AGBiomedicines2227-90592025-02-0113249710.3390/biomedicines13020497Secondary NeutropeniasAlister C. Ward0School of Medicine, Deakin University, Waurn Ponds, VIC 3216, AustraliaNeutrophils are a critical component of immunity, particularly against bacteria and other pathogens, but also in inflammation and tissue repair. As a consequence, individuals with neutropenia, defined by a reduction in absolute neutrophil counts, exhibit a strong propensity to severe infections that typically present with muted symptoms. Neutropenias encompass a heterogeneous set of disorders, comprising primary neutropenias, in which specific genes are mutated, and the more common secondary neutropenias, which have diverse non-genetic causes. These include hematological and other cancers, involving both direct effects of the cancer itself and indirect impacts via the chemotherapeutic, biological agents and cell-based approaches used for treatment. Other significant causes of secondary neutropenias are non-chemotherapeutic drugs, autoimmune and other immune diseases, infections and nutrient deficiencies. These collectively act by impacting neutrophil production in the bone marrow and/or destruction throughout the body. This review describes the biological and clinical manifestations of secondary neutropenias, detailing their underlying causes and management, with a discussion of alternative and emerging therapeutic approaches.https://www.mdpi.com/2227-9059/13/2/497cancerchemotherapyinfectionneutropenianeutrophil |
| spellingShingle | Alister C. Ward Secondary Neutropenias Biomedicines cancer chemotherapy infection neutropenia neutrophil |
| title | Secondary Neutropenias |
| title_full | Secondary Neutropenias |
| title_fullStr | Secondary Neutropenias |
| title_full_unstemmed | Secondary Neutropenias |
| title_short | Secondary Neutropenias |
| title_sort | secondary neutropenias |
| topic | cancer chemotherapy infection neutropenia neutrophil |
| url | https://www.mdpi.com/2227-9059/13/2/497 |
| work_keys_str_mv | AT alistercward secondaryneutropenias |