Microbiological mechanisms of oral mucosal disease: oral-intestinal crosstalk and probiotic therapy
Balance of the oral-intestinal axis microbiota is essential for maintaining oral mucosal health. The occurrence of oral disease is closely linked to the microbiota, this disorder is closely related to the pathogenesis of oral mucosal diseases, such as oral lichen planus, recurrent aphthous ulcer, or...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Oral Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2025.1485028/full |
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| author | Qi Zhou Panpan Liu Muni Chen Hao He Mengting Xu Qianrong Xu Jianfeng Yu Yutian Deng Jiayu Yan Jiayu Yan Jiayu Yan Yueqiang Wen |
| author_facet | Qi Zhou Panpan Liu Muni Chen Hao He Mengting Xu Qianrong Xu Jianfeng Yu Yutian Deng Jiayu Yan Jiayu Yan Jiayu Yan Yueqiang Wen |
| author_sort | Qi Zhou |
| collection | DOAJ |
| description | Balance of the oral-intestinal axis microbiota is essential for maintaining oral mucosal health. The occurrence of oral disease is closely linked to the microbiota, this disorder is closely related to the pathogenesis of oral mucosal diseases, such as oral lichen planus, recurrent aphthous ulcer, oral candidiasis and squamous-cell carcinoma. As a microorganism that is beneficial to host health, probiotics can show multi-dimensional therapeutic effects in oral mucosal diseases by targeting and regulating the immune microenvironment of the oral mucosa, inhibiting the colonization of pathogenic bacteria and repairing the barrier function. In this review, we will review the relevant roles that oral-gut microbial homeostasis plays in the pathogenesis of oral mucosal diseases and provide evidence for dysregulation of microbial homeostasis in patients with oral mucosal diseases, and explore specific probiotic strains by regulating oral and intestinal axis microbial homeostasis and host immune and inflammatory responses, in order to provide new ideas for the clinical treatment of oral mucosal diseases. |
| format | Article |
| id | doaj-art-cd459e815f0e42c781f6d3d7cc70f034 |
| institution | Kabale University |
| issn | 2673-4842 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oral Health |
| spelling | doaj-art-cd459e815f0e42c781f6d3d7cc70f0342025-08-21T05:27:31ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422025-08-01610.3389/froh.2025.14850281485028Microbiological mechanisms of oral mucosal disease: oral-intestinal crosstalk and probiotic therapyQi Zhou0Panpan Liu1Muni Chen2Hao He3Mengting Xu4Qianrong Xu5Jianfeng Yu6Yutian Deng7Jiayu Yan8Jiayu Yan9Jiayu Yan10Yueqiang Wen11School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Stomatology, Sichuan Integrated Traditional and Western Medicine Hospital, Chengdu, ChinaDepartment of Stomatology, Sichuan Integrated Traditional and Western Medicine Hospital, Chengdu, ChinaDepartment of Stomatology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Stomatology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Stomatology, Sichuan Integrated Traditional and Western Medicine Hospital, Chengdu, ChinaSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Stomatology, Sichuan Integrated Traditional and Western Medicine Hospital, Chengdu, ChinaDepartment of Stomatology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaBalance of the oral-intestinal axis microbiota is essential for maintaining oral mucosal health. The occurrence of oral disease is closely linked to the microbiota, this disorder is closely related to the pathogenesis of oral mucosal diseases, such as oral lichen planus, recurrent aphthous ulcer, oral candidiasis and squamous-cell carcinoma. As a microorganism that is beneficial to host health, probiotics can show multi-dimensional therapeutic effects in oral mucosal diseases by targeting and regulating the immune microenvironment of the oral mucosa, inhibiting the colonization of pathogenic bacteria and repairing the barrier function. In this review, we will review the relevant roles that oral-gut microbial homeostasis plays in the pathogenesis of oral mucosal diseases and provide evidence for dysregulation of microbial homeostasis in patients with oral mucosal diseases, and explore specific probiotic strains by regulating oral and intestinal axis microbial homeostasis and host immune and inflammatory responses, in order to provide new ideas for the clinical treatment of oral mucosal diseases.https://www.frontiersin.org/articles/10.3389/froh.2025.1485028/fulloral microbiotaintestinal microbiotaoral-intestinal axisoral mucosal diseaseprobiotics |
| spellingShingle | Qi Zhou Panpan Liu Muni Chen Hao He Mengting Xu Qianrong Xu Jianfeng Yu Yutian Deng Jiayu Yan Jiayu Yan Jiayu Yan Yueqiang Wen Microbiological mechanisms of oral mucosal disease: oral-intestinal crosstalk and probiotic therapy Frontiers in Oral Health oral microbiota intestinal microbiota oral-intestinal axis oral mucosal disease probiotics |
| title | Microbiological mechanisms of oral mucosal disease: oral-intestinal crosstalk and probiotic therapy |
| title_full | Microbiological mechanisms of oral mucosal disease: oral-intestinal crosstalk and probiotic therapy |
| title_fullStr | Microbiological mechanisms of oral mucosal disease: oral-intestinal crosstalk and probiotic therapy |
| title_full_unstemmed | Microbiological mechanisms of oral mucosal disease: oral-intestinal crosstalk and probiotic therapy |
| title_short | Microbiological mechanisms of oral mucosal disease: oral-intestinal crosstalk and probiotic therapy |
| title_sort | microbiological mechanisms of oral mucosal disease oral intestinal crosstalk and probiotic therapy |
| topic | oral microbiota intestinal microbiota oral-intestinal axis oral mucosal disease probiotics |
| url | https://www.frontiersin.org/articles/10.3389/froh.2025.1485028/full |
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