Factors Affecting Glomerular Filtration Rate and Length of Hospitalization in Pediatric Acute Poststreptococcal Glomerulonephritis: A Decade-Long Observational Study
Introduction: Acute poststreptococcal glomerulonephritis (APSGN) remains a significant public health concern, especially in pediatric populations. This decadelong observational study aims to provide a comprehensive exploration of pediatric APSGN, emphasizing on factors those influencing glomerular f...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2024-04-01
|
| Series: | Güncel Pediatri |
| Subjects: | |
| Online Access: | https://www.guncelpediatri.com/articles/factors-affecting-glomerular-filtration-rate-and-length-of-hospitalization-in-pediatric-acute-poststreptococcal-glomerulonephritis-a-decade-long-observational-study/doi/jcp.2024.55476 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850061145171296256 |
|---|---|
| author | Doğukan Mustafa Keskin Pınar Belviranlı Keskin Mehmet Kocaoğlu Alper Yıldırım Oğuz Eğil |
| author_facet | Doğukan Mustafa Keskin Pınar Belviranlı Keskin Mehmet Kocaoğlu Alper Yıldırım Oğuz Eğil |
| author_sort | Doğukan Mustafa Keskin |
| collection | DOAJ |
| description | Introduction: Acute poststreptococcal glomerulonephritis (APSGN) remains a significant public health concern, especially in pediatric populations. This decadelong observational study aims to provide a comprehensive exploration of pediatric APSGN, emphasizing on factors those influencing glomerular filtration rate (GFR) and also contributing to prolonged hospitalization.
Materials and Methods: The single-center, observational, retrospective study was conducted from January 2010 to December 2020 and included children aged 3-18 years diagnosed with APSGN. Diagnostic criteria included hematuria, decreased serum complement-3 levels, and evidence of recent streptococcal infection. Data extracted from medical records encompassed demographic details, clinical features, and a range of laboratory parameters.
Results: Forty-four patients with APSGN were included (mean age: 8.65±3.31 years), 54.55% of whom were male. Hematuria was present in all cases (macroscopic hematuria in 77.27% of patients), edema in 63.64% of cases, and hypertension in 50.00% of cases. There was a negative correlation between inflammatory markers (C-reactive protein, neutrophil count, and neutrophil-to-lymphocyte ratio) and GFR (r: -0.511, r: -0.302, r: -0.380; p :< 0.05 respectively). Decreased GFR, albumin, and complement-3 levels (r: -0.361, r: -0.442, r: -0.315; p :< 0.05, respectively), and increased urine density and urinary protein excretion, correlated significantly with prolonged hospitalization r: 0.413, r: 0.362; p:< 0.05, respectively).
Conclusion: Despite the generally favorable prognosis of pediatric APSGN, this study highlights the potential for severe complications. Elevated inflammatory markers signal severe renal involvement, while decreased GFR, albumin, and complement-3 levels, as well as increased urine density and protein excretion, lead to extended hospital stays. These findings may be used for anticipating patient outcomes and optimizing resource utilization in pediatric APSGN care. |
| format | Article |
| id | doaj-art-cd43945dace44746b7f5c47ec991e37c |
| institution | DOAJ |
| issn | 1304-9054 1308-6308 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Güncel Pediatri |
| spelling | doaj-art-cd43945dace44746b7f5c47ec991e37c2025-08-20T02:50:20ZengGalenos Publishing HouseGüncel Pediatri1304-90541308-63082024-04-012211810.4274/jcp.2024.55476Factors Affecting Glomerular Filtration Rate and Length of Hospitalization in Pediatric Acute Poststreptococcal Glomerulonephritis: A Decade-Long Observational StudyDoğukan Mustafa Keskin0https://orcid.org/0000-0002-5706-5599Pınar Belviranlı Keskin1https://orcid.org/0000-0003-3921-384XMehmet Kocaoğlu2https://orcid.org/0000-0001-9402-9258Alper Yıldırım3https://orcid.org/0000-0001-8502-5298Oğuz Eğil4https://orcid.org/0000-0001-5112-5733Dr. Ali Kemal Belviranli Obstetrics and Gynecology Hospital, Clinic of Pediatrics, Konya, TurkeyNecmettin Erbakan University Meram Faculty of Medicine, Department of Infectious Disease, Konya, TurkeyDr. Ali Kemal Belviranli Obstetrics and Gynecology Hospital, Clinic of Pediatrics, Konya, TurkeyDr. Ali Kemal Belviranli Obstetrics and Gynecology Hospital, Clinic of Pediatrics, Konya, TurkeyCengiz Gökçek Obstetrics and Gynecology Hospital, Clinic of Pediatrics, Gaziantep, TurkeyIntroduction: Acute poststreptococcal glomerulonephritis (APSGN) remains a significant public health concern, especially in pediatric populations. This decadelong observational study aims to provide a comprehensive exploration of pediatric APSGN, emphasizing on factors those influencing glomerular filtration rate (GFR) and also contributing to prolonged hospitalization. Materials and Methods: The single-center, observational, retrospective study was conducted from January 2010 to December 2020 and included children aged 3-18 years diagnosed with APSGN. Diagnostic criteria included hematuria, decreased serum complement-3 levels, and evidence of recent streptococcal infection. Data extracted from medical records encompassed demographic details, clinical features, and a range of laboratory parameters. Results: Forty-four patients with APSGN were included (mean age: 8.65±3.31 years), 54.55% of whom were male. Hematuria was present in all cases (macroscopic hematuria in 77.27% of patients), edema in 63.64% of cases, and hypertension in 50.00% of cases. There was a negative correlation between inflammatory markers (C-reactive protein, neutrophil count, and neutrophil-to-lymphocyte ratio) and GFR (r: -0.511, r: -0.302, r: -0.380; p :< 0.05 respectively). Decreased GFR, albumin, and complement-3 levels (r: -0.361, r: -0.442, r: -0.315; p :< 0.05, respectively), and increased urine density and urinary protein excretion, correlated significantly with prolonged hospitalization r: 0.413, r: 0.362; p:< 0.05, respectively). Conclusion: Despite the generally favorable prognosis of pediatric APSGN, this study highlights the potential for severe complications. Elevated inflammatory markers signal severe renal involvement, while decreased GFR, albumin, and complement-3 levels, as well as increased urine density and protein excretion, lead to extended hospital stays. These findings may be used for anticipating patient outcomes and optimizing resource utilization in pediatric APSGN care.https://www.guncelpediatri.com/articles/factors-affecting-glomerular-filtration-rate-and-length-of-hospitalization-in-pediatric-acute-poststreptococcal-glomerulonephritis-a-decade-long-observational-study/doi/jcp.2024.55476acute post-streptococcal glomerulonephritisglomerular filtration ratehematurianephritic syndromepediatric nephrology |
| spellingShingle | Doğukan Mustafa Keskin Pınar Belviranlı Keskin Mehmet Kocaoğlu Alper Yıldırım Oğuz Eğil Factors Affecting Glomerular Filtration Rate and Length of Hospitalization in Pediatric Acute Poststreptococcal Glomerulonephritis: A Decade-Long Observational Study Güncel Pediatri acute post-streptococcal glomerulonephritis glomerular filtration rate hematuria nephritic syndrome pediatric nephrology |
| title | Factors Affecting Glomerular Filtration Rate and Length of Hospitalization in Pediatric Acute Poststreptococcal Glomerulonephritis: A Decade-Long Observational Study |
| title_full | Factors Affecting Glomerular Filtration Rate and Length of Hospitalization in Pediatric Acute Poststreptococcal Glomerulonephritis: A Decade-Long Observational Study |
| title_fullStr | Factors Affecting Glomerular Filtration Rate and Length of Hospitalization in Pediatric Acute Poststreptococcal Glomerulonephritis: A Decade-Long Observational Study |
| title_full_unstemmed | Factors Affecting Glomerular Filtration Rate and Length of Hospitalization in Pediatric Acute Poststreptococcal Glomerulonephritis: A Decade-Long Observational Study |
| title_short | Factors Affecting Glomerular Filtration Rate and Length of Hospitalization in Pediatric Acute Poststreptococcal Glomerulonephritis: A Decade-Long Observational Study |
| title_sort | factors affecting glomerular filtration rate and length of hospitalization in pediatric acute poststreptococcal glomerulonephritis a decade long observational study |
| topic | acute post-streptococcal glomerulonephritis glomerular filtration rate hematuria nephritic syndrome pediatric nephrology |
| url | https://www.guncelpediatri.com/articles/factors-affecting-glomerular-filtration-rate-and-length-of-hospitalization-in-pediatric-acute-poststreptococcal-glomerulonephritis-a-decade-long-observational-study/doi/jcp.2024.55476 |
| work_keys_str_mv | AT dogukanmustafakeskin factorsaffectingglomerularfiltrationrateandlengthofhospitalizationinpediatricacutepoststreptococcalglomerulonephritisadecadelongobservationalstudy AT pınarbelviranlıkeskin factorsaffectingglomerularfiltrationrateandlengthofhospitalizationinpediatricacutepoststreptococcalglomerulonephritisadecadelongobservationalstudy AT mehmetkocaoglu factorsaffectingglomerularfiltrationrateandlengthofhospitalizationinpediatricacutepoststreptococcalglomerulonephritisadecadelongobservationalstudy AT alperyıldırım factorsaffectingglomerularfiltrationrateandlengthofhospitalizationinpediatricacutepoststreptococcalglomerulonephritisadecadelongobservationalstudy AT oguzegil factorsaffectingglomerularfiltrationrateandlengthofhospitalizationinpediatricacutepoststreptococcalglomerulonephritisadecadelongobservationalstudy |