Factors Affecting Glomerular Filtration Rate and Length of Hospitalization in Pediatric Acute Poststreptococcal Glomerulonephritis: A Decade-Long Observational Study
Introduction: Acute poststreptococcal glomerulonephritis (APSGN) remains a significant public health concern, especially in pediatric populations. This decadelong observational study aims to provide a comprehensive exploration of pediatric APSGN, emphasizing on factors those influencing glomerular f...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2024-04-01
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| Series: | Güncel Pediatri |
| Subjects: | |
| Online Access: | https://www.guncelpediatri.com/articles/factors-affecting-glomerular-filtration-rate-and-length-of-hospitalization-in-pediatric-acute-poststreptococcal-glomerulonephritis-a-decade-long-observational-study/doi/jcp.2024.55476 |
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| Summary: | Introduction: Acute poststreptococcal glomerulonephritis (APSGN) remains a significant public health concern, especially in pediatric populations. This decadelong observational study aims to provide a comprehensive exploration of pediatric APSGN, emphasizing on factors those influencing glomerular filtration rate (GFR) and also contributing to prolonged hospitalization.
Materials and Methods: The single-center, observational, retrospective study was conducted from January 2010 to December 2020 and included children aged 3-18 years diagnosed with APSGN. Diagnostic criteria included hematuria, decreased serum complement-3 levels, and evidence of recent streptococcal infection. Data extracted from medical records encompassed demographic details, clinical features, and a range of laboratory parameters.
Results: Forty-four patients with APSGN were included (mean age: 8.65±3.31 years), 54.55% of whom were male. Hematuria was present in all cases (macroscopic hematuria in 77.27% of patients), edema in 63.64% of cases, and hypertension in 50.00% of cases. There was a negative correlation between inflammatory markers (C-reactive protein, neutrophil count, and neutrophil-to-lymphocyte ratio) and GFR (r: -0.511, r: -0.302, r: -0.380; p :< 0.05 respectively). Decreased GFR, albumin, and complement-3 levels (r: -0.361, r: -0.442, r: -0.315; p :< 0.05, respectively), and increased urine density and urinary protein excretion, correlated significantly with prolonged hospitalization r: 0.413, r: 0.362; p:< 0.05, respectively).
Conclusion: Despite the generally favorable prognosis of pediatric APSGN, this study highlights the potential for severe complications. Elevated inflammatory markers signal severe renal involvement, while decreased GFR, albumin, and complement-3 levels, as well as increased urine density and protein excretion, lead to extended hospital stays. These findings may be used for anticipating patient outcomes and optimizing resource utilization in pediatric APSGN care. |
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| ISSN: | 1304-9054 1308-6308 |