High-dose vitamin C as a targeted treatment for KRAS-driven cancers?

High-dose vitamin C as a targeted treatment for KRAS-driven cancers?

KRAS mutations are frequently observed in human cancer and are associated with proliferation, therapy-resistance and worse outcome. Regrettably, only a fraction of possible mutations is druggable. Therefore, a tailored and possibly cost-effective method to overcome this issue is urgently needed.Rece...

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Bibliographic Details
Main Authors: Elisabeth Mack, Christian Rau, Cornelia Otet, Jonas Aaron Schäfer, Cornelia Brendel, Albert Grass, Peer Bredow, Christian Hohl, Carsten Denkert, Frank Willeke, Andreas Neubauer
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002393
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