Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma
ABSTRACT Background Head and neck mucosal melanoma (HNMM) is rare and carries a poor prognosis with high rates of disease progression. There is little data regarding the use of adjuvant proton radiation therapy in the management of sinonasal HNMM. Aims We performed a retrospective review of patients...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.70111 |
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| author | Jamie S. K. Takayesu Upendra Parvathaneni George E. Laramore Neil Panjwani Jennifer Sillings Neal D. Futran Ian M. Humphreys Aria Jafari Waleed M. Abuzeid Brittany Barber Emily Marchiano Sylvia M. Lee John A. Thompson Evan Hall Shailender Bhatia Cristina P. Rodriguez Jay J. Liao |
| author_facet | Jamie S. K. Takayesu Upendra Parvathaneni George E. Laramore Neil Panjwani Jennifer Sillings Neal D. Futran Ian M. Humphreys Aria Jafari Waleed M. Abuzeid Brittany Barber Emily Marchiano Sylvia M. Lee John A. Thompson Evan Hall Shailender Bhatia Cristina P. Rodriguez Jay J. Liao |
| author_sort | Jamie S. K. Takayesu |
| collection | DOAJ |
| description | ABSTRACT Background Head and neck mucosal melanoma (HNMM) is rare and carries a poor prognosis with high rates of disease progression. There is little data regarding the use of adjuvant proton radiation therapy in the management of sinonasal HNMM. Aims We performed a retrospective review of patients with nonmetastatic sinonasal HNMM treated with adjuvant proton radiation from 2012 to 2022 at a single academic institution. Kaplan–Meier estimates were used for survival analyses. Methods and Results Eight patients with sinonasal HNMM were treated with surgery and adjuvant proton radiation, and six received systemic therapy. Median follow‐up was 15 months (range: 3–68 months). Only one local failure was observed, and two patients developed distant metastases. Kaplan–Meier 1‐year results were as follows: local control 88%, distant metastasis‐free survival 75%, and overall survival 88%. No Grade 3 or higher late toxicities were observed. Conclusion Surgical resection and adjuvant proton radiation provided early favorable local control and toxicity profiles in our cohort of patients with sinonasal HNMM. Further multi‐institutional work is needed to study this rare malignancy. |
| format | Article |
| id | doaj-art-cd3e968cb932425eb39fe712534405ea |
| institution | DOAJ |
| issn | 2573-8348 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj-art-cd3e968cb932425eb39fe712534405ea2025-08-20T03:04:53ZengWileyCancer Reports2573-83482025-02-0182n/an/a10.1002/cnr2.70111Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal MelanomaJamie S. K. Takayesu0Upendra Parvathaneni1George E. Laramore2Neil Panjwani3Jennifer Sillings4Neal D. Futran5Ian M. Humphreys6Aria Jafari7Waleed M. Abuzeid8Brittany Barber9Emily Marchiano10Sylvia M. Lee11John A. Thompson12Evan Hall13Shailender Bhatia14Cristina P. Rodriguez15Jay J. Liao16Department of Radiation Oncology University of Washington Seattle Washington USADepartment of Radiation Oncology University of Washington Seattle Washington USADepartment of Radiation Oncology University of Washington Seattle Washington USADepartment of Radiation Oncology University of Washington Seattle Washington USADepartment of Radiation Oncology University of Washington Seattle Washington USADepartment of Otolaryngology‐Head and Neck Surgery University of Washington Seattle Washington USADepartment of Otolaryngology‐Head and Neck Surgery University of Washington Seattle Washington USADepartment of Otolaryngology‐Head and Neck Surgery University of Washington Seattle Washington USADepartment of Otolaryngology‐Head and Neck Surgery University of Washington Seattle Washington USADepartment of Otolaryngology‐Head and Neck Surgery University of Washington Seattle Washington USADepartment of Otolaryngology‐Head and Neck Surgery University of Washington Seattle Washington USADepartment of Hematology and Oncology University of Washington Seattle Washington USADepartment of Hematology and Oncology University of Washington Seattle Washington USADepartment of Hematology and Oncology University of Washington Seattle Washington USADepartment of Hematology and Oncology University of Washington Seattle Washington USADepartment of Hematology and Oncology University of Washington Seattle Washington USADepartment of Radiation Oncology University of Washington Seattle Washington USAABSTRACT Background Head and neck mucosal melanoma (HNMM) is rare and carries a poor prognosis with high rates of disease progression. There is little data regarding the use of adjuvant proton radiation therapy in the management of sinonasal HNMM. Aims We performed a retrospective review of patients with nonmetastatic sinonasal HNMM treated with adjuvant proton radiation from 2012 to 2022 at a single academic institution. Kaplan–Meier estimates were used for survival analyses. Methods and Results Eight patients with sinonasal HNMM were treated with surgery and adjuvant proton radiation, and six received systemic therapy. Median follow‐up was 15 months (range: 3–68 months). Only one local failure was observed, and two patients developed distant metastases. Kaplan–Meier 1‐year results were as follows: local control 88%, distant metastasis‐free survival 75%, and overall survival 88%. No Grade 3 or higher late toxicities were observed. Conclusion Surgical resection and adjuvant proton radiation provided early favorable local control and toxicity profiles in our cohort of patients with sinonasal HNMM. Further multi‐institutional work is needed to study this rare malignancy.https://doi.org/10.1002/cnr2.70111immunotherapymucosal melanomaprotonsradiation therapysinonasal cancer |
| spellingShingle | Jamie S. K. Takayesu Upendra Parvathaneni George E. Laramore Neil Panjwani Jennifer Sillings Neal D. Futran Ian M. Humphreys Aria Jafari Waleed M. Abuzeid Brittany Barber Emily Marchiano Sylvia M. Lee John A. Thompson Evan Hall Shailender Bhatia Cristina P. Rodriguez Jay J. Liao Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma Cancer Reports immunotherapy mucosal melanoma protons radiation therapy sinonasal cancer |
| title | Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma |
| title_full | Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma |
| title_fullStr | Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma |
| title_full_unstemmed | Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma |
| title_short | Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma |
| title_sort | adjuvant proton beam radiation therapy for sinonasal mucosal melanoma |
| topic | immunotherapy mucosal melanoma protons radiation therapy sinonasal cancer |
| url | https://doi.org/10.1002/cnr2.70111 |
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