Alterations of triple network dynamic connectivity and repetitive behaviors after mini-basketball training program in children with autism spectrum disorder
Abstract Physical exercise has been demonstrated to effectively mitigate repetitive behaviors in children with autism spectrum disorder (ASD), but the underlying dynamic brain network mechanisms are poorly understood. The triple network model consists of three brain networks that jointly regulate co...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-87248-5 |
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| author | Weike Zhang Kelong Cai Xuan Xiong Lina Zhu Zhiyuan Sun Sixin Yang Wei Cheng Haiyong Mao Aiguo Chen |
| author_facet | Weike Zhang Kelong Cai Xuan Xiong Lina Zhu Zhiyuan Sun Sixin Yang Wei Cheng Haiyong Mao Aiguo Chen |
| author_sort | Weike Zhang |
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| description | Abstract Physical exercise has been demonstrated to effectively mitigate repetitive behaviors in children with autism spectrum disorder (ASD), but the underlying dynamic brain network mechanisms are poorly understood. The triple network model consists of three brain networks that jointly regulate cognitive and emotional processes and is considered to be the core network underlying the aberrant manifestations of ASD. This study investigated whether a mini-basketball training program (MBTP) could alter repetitive behaviors and the dynamic connectivity of the triple network. 28 male children with ASD were scanned twice with resting-state functional MRI and assessed for repetitive behaviors using the repetitive behavior scale (RBS-R). 15 children in the exercise group participated in a 12-week MBTP, while 13 in the control group maintained their regular routines. The feature of Dynamic independent component analysis (dyn-ICA) is its ability to capture the rate of change in connectivity between brain regions. In this study, it was specifically employed to examine the triple network dynamic connectivity in both groups. Compared to the control group, the exercise group exhibited distinct dynamic connectivity patterns in two networks: Network 1 involved cross-network dynamic connectivity changes within the triple network, and Network 2 pertained to dynamic connectivity alterations within the default mode network. Furthermore, a reduction in the RBS-R Total score was observed in the exercise group, reflecting improvements in self-injurious behavior and restricted behavior. Correlation analysis revealed that the amelioration of repetitive behaviors was associated with enhanced dynamic connectivity in parts of the triple network. These findings suggest that MBTP can improve repetitive behaviors in ASD children and is linked to changes in triple network dynamic connectivity. |
| format | Article |
| id | doaj-art-cd3e550cb39a4ae8935186079921e066 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-cd3e550cb39a4ae8935186079921e0662025-01-26T12:32:46ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-025-87248-5Alterations of triple network dynamic connectivity and repetitive behaviors after mini-basketball training program in children with autism spectrum disorderWeike Zhang0Kelong Cai1Xuan Xiong2Lina Zhu3Zhiyuan Sun4Sixin Yang5Wei Cheng6Haiyong Mao7Aiguo Chen8Nanjing Sport InstituteCollege of Physical Education, Yangzhou UniversityDepartment of Physical Education, Nanjing UniversityCollege of Physical Education, Yangzhou UniversityCollege of Physical Education, Yangzhou UniversityNantong Middle SchoolJiangsu Shipping CollegeCollege of Physical Education, Yangzhou UniversityNanjing Sport InstituteAbstract Physical exercise has been demonstrated to effectively mitigate repetitive behaviors in children with autism spectrum disorder (ASD), but the underlying dynamic brain network mechanisms are poorly understood. The triple network model consists of three brain networks that jointly regulate cognitive and emotional processes and is considered to be the core network underlying the aberrant manifestations of ASD. This study investigated whether a mini-basketball training program (MBTP) could alter repetitive behaviors and the dynamic connectivity of the triple network. 28 male children with ASD were scanned twice with resting-state functional MRI and assessed for repetitive behaviors using the repetitive behavior scale (RBS-R). 15 children in the exercise group participated in a 12-week MBTP, while 13 in the control group maintained their regular routines. The feature of Dynamic independent component analysis (dyn-ICA) is its ability to capture the rate of change in connectivity between brain regions. In this study, it was specifically employed to examine the triple network dynamic connectivity in both groups. Compared to the control group, the exercise group exhibited distinct dynamic connectivity patterns in two networks: Network 1 involved cross-network dynamic connectivity changes within the triple network, and Network 2 pertained to dynamic connectivity alterations within the default mode network. Furthermore, a reduction in the RBS-R Total score was observed in the exercise group, reflecting improvements in self-injurious behavior and restricted behavior. Correlation analysis revealed that the amelioration of repetitive behaviors was associated with enhanced dynamic connectivity in parts of the triple network. These findings suggest that MBTP can improve repetitive behaviors in ASD children and is linked to changes in triple network dynamic connectivity.https://doi.org/10.1038/s41598-025-87248-5Physical exerciseAutism spectrum disorderDynamic independent component analysisTriple network |
| spellingShingle | Weike Zhang Kelong Cai Xuan Xiong Lina Zhu Zhiyuan Sun Sixin Yang Wei Cheng Haiyong Mao Aiguo Chen Alterations of triple network dynamic connectivity and repetitive behaviors after mini-basketball training program in children with autism spectrum disorder Scientific Reports Physical exercise Autism spectrum disorder Dynamic independent component analysis Triple network |
| title | Alterations of triple network dynamic connectivity and repetitive behaviors after mini-basketball training program in children with autism spectrum disorder |
| title_full | Alterations of triple network dynamic connectivity and repetitive behaviors after mini-basketball training program in children with autism spectrum disorder |
| title_fullStr | Alterations of triple network dynamic connectivity and repetitive behaviors after mini-basketball training program in children with autism spectrum disorder |
| title_full_unstemmed | Alterations of triple network dynamic connectivity and repetitive behaviors after mini-basketball training program in children with autism spectrum disorder |
| title_short | Alterations of triple network dynamic connectivity and repetitive behaviors after mini-basketball training program in children with autism spectrum disorder |
| title_sort | alterations of triple network dynamic connectivity and repetitive behaviors after mini basketball training program in children with autism spectrum disorder |
| topic | Physical exercise Autism spectrum disorder Dynamic independent component analysis Triple network |
| url | https://doi.org/10.1038/s41598-025-87248-5 |
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