Safety Profile, Toxicokinetic, and Intestinal Absorption Differences of a Naturally-Derived Anti-Rheumatic Drug, Sinomenine Hydrochloride, in Normal and Arthritic Rats

<b>Background/Objective</b>: Sinomenine hydrochloride (SH), a natural anti–rheumatic drug derived from the Chinese medicinal plant <i>Sinomenium acutum</i>, demonstrates disease–modifying properties but lacks comprehensive safety and toxicokinetic (TK) comparisons between phy...

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Bibliographic Details
Main Authors:	Yini He, Hong Huang, Gejing Li, Ye Zhang, Junjie He, Ye Lin, Feichi Wu, Jianye Yan, Xiong Cai, Liang Liu
Format:	Article
Language:	English
Published:	MDPI AG 2025-04-01
Series:	Pharmaceutics
Subjects:	sinomenine hydrochloride adjuvant-induced arthritis safety profile toxicokinetic intestinal absorption P–glycoprotein
Online Access:	https://www.mdpi.com/1999-4923/17/4/484
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