Foundational contributions of Svetlana Mojsov to the GLP-1 field
Biochemist Svetlana Mojsov, both as a graduate student at The Rockefeller University under the mentorship of Bruce Merrifield during the 1970s, and as an independent investigator at the Massachusetts General Hospital (MGH) during the 1980s, devised effective and robust methods for the chemical synth...
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Open Exploration
2024-10-01
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| Series: | Exploration of Drug Science |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100869/100869.pdf |
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| author | George Barany Michael J. Barany |
| author_facet | George Barany Michael J. Barany |
| author_sort | George Barany |
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| description | Biochemist Svetlana Mojsov, both as a graduate student at The Rockefeller University under the mentorship of Bruce Merrifield during the 1970s, and as an independent investigator at the Massachusetts General Hospital (MGH) during the 1980s, devised effective and robust methods for the chemical synthesis of the peptide hormones glucagon and glucagon-like peptide (GLP-1), along with numerous analogues of these key biomolecules. Working separately from MGH’s powerhouse endocrine research laboratory, Mojsov developed a tool-kit of reliable assays that were indispensable to later in vitro and in vivo collaborative studies that established profound insulinotropic effects of this peptide family, findings that were subsequently harnessed clinically with blockbuster drugs directed at often-serious endocrine conditions such as type 2 diabetes and obesity. Significantly, Mojsov was the first to recognize the critical cleavage sites in preproglucagon that give rise to the biologically active species, a truncated form known as GLP-1 (7–37), and carried out the key experiments that proved her hypothesis. Despite being the first author on critical formative publications for the field, and being acknowledged, along with Joel Habener, as one of two co-inventors on the controlling United States patents, Mojsov’s foundational contributions were initially overlooked when GLP-1 biochemistry began to be the subject of major scientific prizes. Fortunately, Mojsov’s work has, within the past year, been better appreciated and deservedly lauded. |
| format | Article |
| id | doaj-art-cd378c6d12984e63a4de07d0767b1e8c |
| institution | Kabale University |
| issn | 2836-7677 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Open Exploration |
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| series | Exploration of Drug Science |
| spelling | doaj-art-cd378c6d12984e63a4de07d0767b1e8c2025-02-08T03:29:24ZengOpen ExplorationExploration of Drug Science2836-76772024-10-012668870010.37349/eds.2024.00069Foundational contributions of Svetlana Mojsov to the GLP-1 fieldGeorge Barany0https://orcid.org/0000-0002-6373-2706Michael J. Barany1https://orcid.org/0000-0002-4067-5112Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USAScience, Technology and Innovation Studies Subject Group, University of Edinburgh, EH8 9LD Edinburgh, United KingdomBiochemist Svetlana Mojsov, both as a graduate student at The Rockefeller University under the mentorship of Bruce Merrifield during the 1970s, and as an independent investigator at the Massachusetts General Hospital (MGH) during the 1980s, devised effective and robust methods for the chemical synthesis of the peptide hormones glucagon and glucagon-like peptide (GLP-1), along with numerous analogues of these key biomolecules. Working separately from MGH’s powerhouse endocrine research laboratory, Mojsov developed a tool-kit of reliable assays that were indispensable to later in vitro and in vivo collaborative studies that established profound insulinotropic effects of this peptide family, findings that were subsequently harnessed clinically with blockbuster drugs directed at often-serious endocrine conditions such as type 2 diabetes and obesity. Significantly, Mojsov was the first to recognize the critical cleavage sites in preproglucagon that give rise to the biologically active species, a truncated form known as GLP-1 (7–37), and carried out the key experiments that proved her hypothesis. Despite being the first author on critical formative publications for the field, and being acknowledged, along with Joel Habener, as one of two co-inventors on the controlling United States patents, Mojsov’s foundational contributions were initially overlooked when GLP-1 biochemistry began to be the subject of major scientific prizes. Fortunately, Mojsov’s work has, within the past year, been better appreciated and deservedly lauded.https://www.explorationpub.com/uploads/Article/A100869/100869.pdfglucagon-like peptide 1 (glp-1)glucagontype 2 diabetesobesitysolid-phase peptide synthesis (spps)scientific discoverycredit and recognition |
| spellingShingle | George Barany Michael J. Barany Foundational contributions of Svetlana Mojsov to the GLP-1 field Exploration of Drug Science glucagon-like peptide 1 (glp-1) glucagon type 2 diabetes obesity solid-phase peptide synthesis (spps) scientific discovery credit and recognition |
| title | Foundational contributions of Svetlana Mojsov to the GLP-1 field |
| title_full | Foundational contributions of Svetlana Mojsov to the GLP-1 field |
| title_fullStr | Foundational contributions of Svetlana Mojsov to the GLP-1 field |
| title_full_unstemmed | Foundational contributions of Svetlana Mojsov to the GLP-1 field |
| title_short | Foundational contributions of Svetlana Mojsov to the GLP-1 field |
| title_sort | foundational contributions of svetlana mojsov to the glp 1 field |
| topic | glucagon-like peptide 1 (glp-1) glucagon type 2 diabetes obesity solid-phase peptide synthesis (spps) scientific discovery credit and recognition |
| url | https://www.explorationpub.com/uploads/Article/A100869/100869.pdf |
| work_keys_str_mv | AT georgebarany foundationalcontributionsofsvetlanamojsovtotheglp1field AT michaeljbarany foundationalcontributionsofsvetlanamojsovtotheglp1field |