The Potential Regulators of Amyloidogenic Pathway of APP Processing in Alzheimer’s Disease
The amyloidogenic processing of amyloid precursor protein (APP) plays a pivotal role in the pathogenesis of Alzheimer’s disease (AD), primarily through the generation of amyloid-beta (Aβ) peptides, which aggregate to form toxic plaques in the brain. The regulation of amyloidogenic APP processing is...
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MDPI AG
2025-06-01
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| author | Daria Krawczuk Agnieszka Kulczyńska-Przybik Barbara Mroczko |
| author_facet | Daria Krawczuk Agnieszka Kulczyńska-Przybik Barbara Mroczko |
| author_sort | Daria Krawczuk |
| collection | DOAJ |
| description | The amyloidogenic processing of amyloid precursor protein (APP) plays a pivotal role in the pathogenesis of Alzheimer’s disease (AD), primarily through the generation of amyloid-beta (Aβ) peptides, which aggregate to form toxic plaques in the brain. The regulation of amyloidogenic APP processing is a complex interplay of enzymes, proteins, and signaling pathways, all of which contribute to the development and progression of Alzheimer’s disease. Understanding the intricate mechanisms and molecular players involved in APP processing substantially enhances our knowledge of Alzheimer’s disease pathology and holds promise for the development of biomarkers of ongoing pathology at the earliest stages of Alzheimer’s disease. In this review, we aimed to investigate selected factors that regulate the amyloidogenic pathway of APP processing. |
| format | Article |
| id | doaj-art-cd31770acaf1489996a2dac8ed121b87 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-cd31770acaf1489996a2dac8ed121b872025-08-20T04:00:50ZengMDPI AGBiomedicines2227-90592025-06-01137151310.3390/biomedicines13071513The Potential Regulators of Amyloidogenic Pathway of APP Processing in Alzheimer’s DiseaseDaria Krawczuk0Agnieszka Kulczyńska-Przybik1Barbara Mroczko2Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Waszyngtona 15A, 15-269 Białystok, PolandDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok, Waszyngtona 15A, 15-269 Białystok, PolandDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok, Waszyngtona 15A, 15-269 Białystok, PolandThe amyloidogenic processing of amyloid precursor protein (APP) plays a pivotal role in the pathogenesis of Alzheimer’s disease (AD), primarily through the generation of amyloid-beta (Aβ) peptides, which aggregate to form toxic plaques in the brain. The regulation of amyloidogenic APP processing is a complex interplay of enzymes, proteins, and signaling pathways, all of which contribute to the development and progression of Alzheimer’s disease. Understanding the intricate mechanisms and molecular players involved in APP processing substantially enhances our knowledge of Alzheimer’s disease pathology and holds promise for the development of biomarkers of ongoing pathology at the earliest stages of Alzheimer’s disease. In this review, we aimed to investigate selected factors that regulate the amyloidogenic pathway of APP processing.https://www.mdpi.com/2227-9059/13/7/1513Alzheimer’s diseaseAPPBACEfurinHIF-1αalcadeins |
| spellingShingle | Daria Krawczuk Agnieszka Kulczyńska-Przybik Barbara Mroczko The Potential Regulators of Amyloidogenic Pathway of APP Processing in Alzheimer’s Disease Biomedicines Alzheimer’s disease APP BACE furin HIF-1α alcadeins |
| title | The Potential Regulators of Amyloidogenic Pathway of APP Processing in Alzheimer’s Disease |
| title_full | The Potential Regulators of Amyloidogenic Pathway of APP Processing in Alzheimer’s Disease |
| title_fullStr | The Potential Regulators of Amyloidogenic Pathway of APP Processing in Alzheimer’s Disease |
| title_full_unstemmed | The Potential Regulators of Amyloidogenic Pathway of APP Processing in Alzheimer’s Disease |
| title_short | The Potential Regulators of Amyloidogenic Pathway of APP Processing in Alzheimer’s Disease |
| title_sort | potential regulators of amyloidogenic pathway of app processing in alzheimer s disease |
| topic | Alzheimer’s disease APP BACE furin HIF-1α alcadeins |
| url | https://www.mdpi.com/2227-9059/13/7/1513 |
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